2012
DOI: 10.3171/2012.2.jns111837
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Elevated body mass index and risk of postoperative CSF leak following transsphenoidal surgery

Abstract: ObjectPostoperative CSF leakage can be a serious complication after a transsphenoidal surgical approach. An elevated body mass index (BMI) is a significant risk factor for spontaneous CSF leaks. However, there is no evidence correlating BMI with postoperative CSF leak after transsphenoidal surgery. The authors hypothesized that patients with elevated BMI would have a higher incidence of CSF leakage complications following transsphenoidal surgery. Show more

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Cited by 120 publications
(166 citation statements)
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“…7 Dlouhy and colleagues 7 performed a retrospective review of 121 patients who underwent TSS, noting that the average BMI of patients with CSF rhinorrhea was greater than those with no postoperative leak. In our analysis, we noted a significantly greater proportion of obesity, as defined by BMI, among Cushing's disease patients than in the non-Cushing's disease cohort.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…7 Dlouhy and colleagues 7 performed a retrospective review of 121 patients who underwent TSS, noting that the average BMI of patients with CSF rhinorrhea was greater than those with no postoperative leak. In our analysis, we noted a significantly greater proportion of obesity, as defined by BMI, among Cushing's disease patients than in the non-Cushing's disease cohort.…”
Section: Discussionmentioning
confidence: 99%
“…5 Despite a superior safety profile and decreased morbidity relative to transcranial approaches, TSS harbors risks, including a potential for hypopituitarism as well as cerebrospinal fluid (CSF) leak. [6][7][8][9][10][11] Some have suggested the latter risk is especially pronounced in Cushing's disease, characterized by poor wound healing due to a high cortisol environment. 12,13 Nonetheless, population-based studies definitively illustrating an increased CSF leak rate in Cushing's disease patients are lacking.…”
Section: Introductionmentioning
confidence: 99%
“…Likewise idiopathic intracranial hypertension associated with a high BMI and young age can also increase the risk of a leak. 4,45 In the present population, age, sex, and BMI did not significantly correlate with CSF leaks. This is not entirely surprising since cranial defects were not spontaneous but rather iatrogenic and the persistence of a leak had more to do with the size of the skull base opening and the success of the repair than the patient's body habitus.…”
Section: Risk Of Csf Leaks Associated With Esbsmentioning
confidence: 68%
“…These factors include expanded EEAs, certain pathologic conditions (ie, craniopharyngioma), postoperative adjuvant therapies, idiopathic intracranial hypertension, and transplanum approaches with exposure of the third ventricle. 24,[27][28][29] Similarly, although the incidence of postoperative CSF leaks following resection of even large pituitary adenomas is less than 10%, EEAs for ventral skull base meningiomas are associated with a considerably higher incidence (more than 30% for olfactory groove and more than 20% for tuberculum sellae meningiomas). 30,31 CSF leaks following FESS are most commonly associated with injury to the ethmoid roof or the LLCP.…”
Section: Surgical Traumatic Cerebrospinal Fluid Leaksmentioning
confidence: 95%