Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1

Kurihara, Yukiko; Kurihara, Hiroki; Suzuki, Hiroshi; Kodama, Tatsuhiko; Maemura, Koji; Nagai, Ryozo; Oda, Hideaki; Kuwaki, Tomoyuki; Cao, Weihua; Kamada, Nobuo; Jishage, Kou-ichi; Ouchi, Yasuyoshi; Azuma, Sadahiro; Toyoda, Yutaka; Ishikawa, Takatoshi; Kumada, Mamoru; Yazaki, Yoshio

doi:10.1038/368703a0

Cited by 957 publications

(584 citation statements)

References 43 publications

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“…Knockout studies indicated a role for ET-1 in bone formation since ET-1 null mice exhibit hypoplasia of the facial bones. ET-1 null mice die shortly after birth from respiratory failure and cardiac abnormalities [30]. Also serum ET-1 levels are increased in patients with bone osteoblastic lesions [31].…”

Section: Osteoblastic Bone Metastasismentioning

confidence: 99%

Mechanisms of cancer metastasis to the bone

Yin¹,

Pollock²,

Kelly³

2005

Cell Res

279

213

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Some of the most common human cancers, including breast cancer, prostate cancer, and lung cancer, metastasize with avidity to bone. What is the basis for their preferential growth within the bone microenvironment? Bidirectional interactions between tumor cells and cells that make up bone result in a selective advantage for tumor growth and can lead to bone destruction or new bone matrix deposition. This review discusses our current understanding of the molecular components and mechanisms that are responsible for those interactions.

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Section: Osteoblastic Bone Metastasismentioning

confidence: 99%

Mechanisms of cancer metastasis to the bone

Yin¹,

Pollock²,

Kelly³

2005

Cell Res

279

213

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“…Further transformations about the hinge are seen with the targeted disruption of both the endothelin signaling pathway and its potential targets, the nested Dlx5 and Dlx6 genes (Kurihara et al, 1994;Clouthier et al, 1998;Yanagisawa et al, 1998;Acampora et al, 1999;Depew et al, 1999;Charite et al, 2001;Ruest et al, 2004). Dlx5 is expressed both in early head mesenchyme (mdBA1 CNC) and epithelia (e.g., the early anterior cephalic ectoderm, ANR, and olfactory and otic placodes; Simeone et al, 1994;Qiu et al, 1997;Yang et al, 1998;Depew et al, 1999).…”

Section: Figmentioning

confidence: 99%

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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Classic neontology (comparative embryology and anatomy), through the application of the concept of homology, has demonstrated that the development of the gnathostome (jawed vertebrate) skull is characterized both by a fidelity to the gnathostome bauplan and the exquisite elaboration of final structural design. Just as homology is an old concept amended for modern purposes, so are many of the questions regarding the development of the skull. With due deference to Geoffroy-St. Hilaire, Cuvier, Owen, Lankester et al., we are still asking: How are bauplan fidelity and elaboration of design maintained, coordinated, and modified to generate the amazing diversity seen in cranial morphologies? What establishes and maintains pattern in the skull? Are there universal developmental mechanisms underlying gnathostome autapomorphic structural traits? Can we detect and identify the etiologies of heterotopic (change in the topology of a developmental event), heterochronic (change in the timing of a developmental event), and heterofacient (change in the active capacetence, or the elaboration of capacity, of a developmental event) changes in craniofacial development within and between taxa? To address whether jaws are all made in a like manner (and if not, then how not), one needs a starting point for the sake of comparison. To this end, we present here a "hinge and caps" model that places the articulation, and subsequently the polarity and modularity, of the upper and lower jaws in the context of cranial neural crest competence to respond to positionally located epithelial signals. This model expands on an evolving model of polarity within the mandibular arch and seeks to explain a developmental patterning system that apparently keeps gnathostome jaws in functional registration yet tractable to potential changes in functional demands over time. It relies upon a system for the establishment of positional information where pattern and placement of the "hinge" is driven by factors common to the junction of the maxillary and mandibular branches of the first arch and of the "caps" by the signals emanating from the distal-most first arch midline and the lamboidal junction (where the maxillary branch meets the frontonasal processes). In this particular model, the functional registration of jaws is achieved by the integration of "hinge" and "caps" signaling, with the "caps" sharing at some critical level a developmental history that potentiates their own coordination. We examine the evidential foundation for this model in mice, examine the robustness with which it can be applied to other taxa, and examine potential proximate sources of the signaling centers. Lastly, as developmental biologists have long held that the anterior-most mesendoderm (anterior archenteron roof or prechordal plate) is in some way integral to the normal formation of the head, including the cranial skeletal midlines, we review evidence that the seminal patterning influences on the early anterior ectoderm extend well beyond the neural plate and are just as importan...

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“…Evidence from EDN1 genetic mutants shows that ET and its converting enzyme are necessary for correct vascular development in the embryo. [68][69][70] Huang et al 71 reported that the EDN1 gene was directly involved in hypertension, and polymorphisms in the gene encoding ET receptor-A have been shown to be associated with essential hypertension testifying to the necessity of balance within the system for normal functioning in vascular tissues. 72 While we have reported on the importance of ET-1 expression in retinal microvasculature in high glucose, 73 there appears to be a lack of association between a polymorphism in the EDN1 gene and diabetic retinopathy after correction.…”

Section: Mhc and Immunity Markersmentioning

confidence: 99%