Elevated blood carboxyhemoglobin levels as an early predictor of phototherapy requirement in moderate and late preterm infants

Varal, İpek Güney; Mengi, Senay; Doğan, Peli̇n; Tutanç, Murat; Bostancı, Muharrem; Cizmeci, Mehmet Nevzat

doi:10.1080/14767058.2018.1542675

Cited by 4 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Schutzman et al 19 found that CO levels did not differ significantly between negative DCT neonates. Varal et al 22 study on middle and late preterm neonates concluded that the initial COHb levels of babies who received phototherapy were significantly higher than those of babies who did not need this treatment, and this difference persisted over consecutive hours. Uetani et al 23 found that COHb levels in neonates with ABO-incompatible hyperbilirubinemia were significantly higher than levels in ABO-compatible neonates with hyperbilirubinemia in term neonates.…”

Section: Discussionmentioning

confidence: 99%

Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

2021

View full text Add to dashboard Cite

Objective This study aimed to assess whether cord blood carboxyhemoglobin (COHb) levels in jaundiced term neonates with and without a positive direct Coombs test (DCT) and in healthy controls could be used as a predictor of severe hyperbilirubinemia. The percentage of cord blood COHb should be higher among neonates with Coombs-positive ABO hemolytic disease than among those with Coombs-negative ABO incompatibility and higher than that of ABO-compatible control neonates. Study Design This cross-sectional descriptive study of 198 term neonates comprised three subgroups: group I featured 68 DCT-positive ABO-incompatible neonates (ABO + DCT), group II featured 60 DCT-negative ABO-incompatible neonates with hyperbilirubinemia (ABO–DCT), and group III featured 70 healthy controls. COHb was determined by an OSM3 hemoximeter. Results Group I differed from groups II and III for cord blood bilirubin, cord blood hemoglobin, and cord blood hematocrit. Groups I and II had higher mean total serum bilirubin (TSB) levels than group III, while there was no difference in the mean TSB levels between groups I and II. There was no significant difference between the COHb group means for groups I, II, and III (p = 0.98). The area under the receiver operating characteristic curve calculated for group I/group III and group II/group III were found to be 0.62 and 0.54, respectively. Conclusion COHb levels did not prove to be superior to the DCT for predicting the risk of developing severe hyperbilirubinemia in term neonates. Key Points

show abstract

Section: Discussionmentioning

confidence: 99%

Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

2021

View full text Add to dashboard Cite

show abstract

“…Because COHb is released early as a breakdown product of heme, it is an early predictor of response to phototherapy for hyperbilirubinemia in preterm infants, with a sensitivity of 90% and a specificity of 88%. 34 Whether COHb serves a similar purpose in dogs with immunemediated hemolytic anemia in predicting the need for adjunctive therapy, such as additional blood transfusions, total plasma exchange, or multiple immunosuppressive medications, deserves exploration.…”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of carboxyhemoglobin and methemoglobin levels in dogs and cats with respiratory disease

Wolf

Hess

Hering

et al. 2022

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Objective To evaluate carboxyhemoglobin (COHb) and methemoglobin (MetHb) levels in dogs and cats with respiratory disease in the ICU. Design Retrospective study. Setting University veterinary teaching hospital. Animals The ICU census was searched for dogs (n = 466) and cats (n = 97) hospitalized within the ICU between January 2016 and January 2019 in whom blood gas with co‐oximetry was performed. Dogs and cats were stratified into those with primary respiratory and nonrespiratory categories; the underlying cause of the disease was also noted. Venous blood gas, co‐oximeter, PaO2/FiO2 (PF ratio), physical examination findings, and outcome were recorded. Measurements and main results The median COHb and MetHb in dogs hospitalized in the ICU were 2.6% (0.1%–5.6%) and 1.1% (0.1%–2.9%), respectively. The median COHb and MetHb in cats hospitalized in the ICU were 2.2% (0.1%–5.4%) and 1.0% (0%–2.1%), respectively. Dogs with respiratory disease had a higher COHb than dogs without respiratory disease (median, 2.7% [range, 0.3%–5.0%] vs. 2.5% [0.1%–5.6%]; P = 0.0148). COHb was positively associated with survival in cats (median, 2.2% [range, 0.1%–5.4%] vs. 1.9% [0.1%–3.9%]; P = 0.0433). Both COHb and MetHb were higher in septic dogs than in nonseptic dogs (median COHb, 2.8% [range 0.3%–4.5%] vs. 2.6% [0.1%–5.6%]; P = 0.02 and median MetHb, 1.1% [0.1%–2.9%] vs. 1.1% [0.1%–2.4%]; P = 0.01, respectively). Conclusions There may be a positive association between COHb and respiratory disease in dogs; prospective studies are needed to evaluate this further. No association between COHb and respiratory disease in cats or MetHb and respiratory disease in either species was detected. Additional prospective studies are needed to determine whether COHb and MetHb are biomarkers for sepsis in dogs and whether COHb is an indicator of mortality in cats.

show abstract

Serial Carboxyhemoglobin Levels and Its Relationship with Late Onset Sepsis in Preterm Infants: An Observational Cohort Study

Varal

Doğan

2019

Fetal and Pediatric Pathology

View full text Add to dashboard Cite

Elevated blood carboxyhemoglobin levels as an early predictor of phototherapy requirement in moderate and late preterm infants

Cited by 4 publications

References 18 publications

Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

Role of Cord Blood Carboxyhemoglobin in Detecting Significant Hyperbilirubinemia in Term Neonates with ABO Alloimmunization

Retrospective evaluation of carboxyhemoglobin and methemoglobin levels in dogs and cats with respiratory disease

Serial Carboxyhemoglobin Levels and Its Relationship with Late Onset Sepsis in Preterm Infants: An Observational Cohort Study

Contact Info

Product

Resources

About