Elevated B-type natriuretic peptide in asymptomatic men with chronic aortic regurgitation and preserved left ventricular systolic function

Eimer, Micah J.; Ekery, Deborah; Rigolin, Vera H.; Bonow, Robert O.; Carnethon, Mercedes R.; Cotts, William

doi:10.1016/j.amjcard.2004.05.043

Cited by 33 publications

(21 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 The distribution of BNP levels among the groups. BNP = type B natriuretic peptide; MS = mitral stenosis [21][22][23][24][25][26][27][28]. However, there was not any difference between our study groups in terms of these factors, which, in our opinion, will enable us to better assess the possible relationship between MS and plasma BNP.…”

Section: Discussioncontrasting

confidence: 51%

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

Eryol

Doğan

Özdoğru

et al. 2006

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are both secreted primarily from the ventricle myocardium in response to the increase in volume and pressure. We aimed to investigate the relationship between the severity of mitral stenosis (MS) and the level of plasma BNP. A total of 56 patients (50 female, 6 male) were included in the study. Mitral stenosis and its related parameters were evaluated by echocardiographic methods. Patients were divided into three groups as with mild, moderate and severe MS according to their planimetric valvular area. Plasma BNP levels were measured using "Triage-B-type natriuretic peptide test" method (Biosite Diagnostics, San Diego). The relationship of BNP with mitral stenosis and other echocardiographic parameters were studied. The comparison of the 3 groups with one another revealed that the BNP level in the group with moderate MS was higher than that in the group with mild MS, however it was statistically insignificant (74.9 +/- 49.7 versus 49.9 +/- 40.5 pg/ml, p > 0.05). BNP level in the group with severe MS was significantly higher than that in the mild MS (144.3 +/- 83.9 versus 49.9 +/- 40.5 pg/ml, p < 0.001) and that in the moderate MS group (144.3 +/- 83.9 versus. 74.9 +/- 49.7 pg/ml, p < 0.05). When patients were taken together, as the area of the mitral valve decreased, the level of BNP underwent a corresponding increase (r:-0.48, p < 0.001). We have ascertained that the level of plasma BNP and the degree of MS are significantly correlated, and as MS becomes more serious, the plasma BNP level rises.

show abstract

Section: Discussioncontrasting

confidence: 51%

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

Eryol

Doğan

Özdoğru

et al. 2006

Int J Cardiovasc Imaging

View full text Add to dashboard Cite

show abstract

“…If that were true, serum levels would be expected to correlate with conventional parameters of LV remodelling such as LVED and LVES. This was indeed observed by Eimer et al, (26) but could not be corroborated in the larger study by Gerber et al (25) However, the latter authors also clearly demonstrated that serum levels were signifi cantly higher in symptomatic patients when compared to asymptomatic patients, and it was deduced that serum levels could not be explained by LV remodelling. The observation that serum levels were increased in these patients, who all …”

Section: Aortic Valve Regurgitation (Ar)supporting

confidence: 46%

“…(25)(26)(27) BNP and NT-proBNP levels are signifi cantly increased in subjects with AR, even in those who are asymptomatic. The correlation between serum levels and valve lesion severity and left ventricular dysfunction is, however, less clear.…”

Section: Aortic Valve Regurgitation (Ar)mentioning

confidence: 99%

Serum brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (NT-proBNP) in heart valve disease

Moolman

Preez

Rossouw

2017

SAHJ

View full text Add to dashboard Cite

Serum levels of natriuretic peptides (BNP and NT-proBNP) are known to increase in cardiac failure, and aid in the diagnosis and management of such patients. BNP and NT-proBNP also increase in patients with heart valve lesions, and may contribute to the assessment and management of these patients. There appears to be a general trend towards higher BNP values in more severe heart valve lesions, but the exact implication of a raised BNP or NTproBNP appears to be different for each specifi c valve lesion. In aortic valve stenosis increased levels of BNP/NT-proBNP correlate with the degree of stenosis, symptoms and prognosis. In addition, the increased natriuretic peptide levels seem to refl ect left ventricular dysfunction, as high levels predict poor long-term outcomes in conservatively treated patients as well as post-operative death and poor functional recovery in those who survive the valve replacement procedure. In mitral regurgitation natriuretic peptide levels correlate with the degree of valvular regurgitation, and seem to refl ect subclinical left ventricular dysfunction. Serum natriuretic peptide levels are elevated in patients with mitral stenosis, and correlate with the degree of valvular stenosis and increased pulmonary pressure. Serum levels of natriuretic peptides are elevated in other heart valve lesions, such as aortic valve regurgitation, as well as different forms of mixed valvular disease, but very little is ABSTRACT BNP AND NT-proBNP IN HEART VALVE DISEASE known about the relationship between the serum levels of natriuretic peptides and the latter valve lesions. The practical application of our knowledge concerning serum natriuretic peptides and heart valve disease is limited at this stage, and no specifi c cut-off values to guide patient management have been incorporated into any offi cial guidelines as yet. This review aims to summarise current knowledge on serum BNP and NT-proBNP levels in patients with heart valve disease. The impact of this information on current clinical decision making in patients with different heart valve lesions, as well as evolving concepts concerning its potential future use, will be discussed.

show abstract

“…Thus, BNP can be an interesting marker of the natural history progression in patients with AF and rather increased ventricular diameters (Figure 2). This theory is corroborated by studies of AF of nonrheumatic etiology where the BNP showed a behavior that was similar to that in our study, i.e., elevated BNP in the presence of symptoms 26 ; however, differently from the results observed in our study, these authors also observed a correlation of the BNP with the ventricular diameter and function in all patients, not only in the symptomatic ones.…”

Section: Bnp Behaviorcontrasting

confidence: 45%

Perfil neuro-hormonal de pacientes reumáticos com insuficiência aórtica crônica importante

Spina

Tarasoutchi

Sampaio

et al. 2009

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

Elevated B-type natriuretic peptide in asymptomatic men with chronic aortic regurgitation and preserved left ventricular systolic function

Cited by 33 publications

References 5 publications

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

The relationship between the level of plasma B-type natriuretic peptide and mitral stenosis

Serum brain natriuretic peptide (BNP) and N-terminal brain natriuretic peptide (NT-proBNP) in heart valve disease

Perfil neuro-hormonal de pacientes reumáticos com insuficiência aórtica crônica importante

Contact Info

Product

Resources

About