Elevated autoantibodies against interleukin‐17F correlate with disease activity in patients with early rheumatoid arthritis

Yang, Lin; Bai, Li; Wei, Feifei; Liu, Yuan; Sun, Lin; Wang, Wenming; Xiangyuan, Liu; Wang, Yongfu

doi:10.1111/1756-185x.12618

Cited by 3 publications

(2 citation statements)

References 32 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their findings indicated that antibody increase in response to IL-17 was directly related to the disease activity of those patients. Such evidence suggests that antibodies against IL-17 may play a protective role against the pathogens of such diseases (Yang et al, 2015). Liu et al, studied the role of IL-17 levels in the synovial fluid and its relationship with knee-arthritis intensity.…”

Section: Discussionmentioning

confidence: 99%

Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

Sarafan¹,

Fakoor²,

Mehdinasab³

et al. 2017

GJHS

View full text Add to dashboard Cite

Background and Objectives: Inflammatory processes play an important role in intra-articular fractures. The present study aimed to examine the relationship between chemerin, high-sensitivity C-reactive protein (hs-CRP), and Interleukin 17 (IL-17) serum and synovial fluid levels of osteoarthritis patients and individuals with intra-articular fractures. Method:In this case-control study, all osteoarthritis patients and individuals with intra-articular fractures who visited the Imam Khomeini Orthopedic Clinic of Ahvaz were examined. Blood samples (5 cc) were collected prior to surgery to measure chemerin Interleukin 17, and hs-CRP serum levels. Synovial fluid samples (2 cc) were collected during the surgery. Results:Measuring the levels of IL-17, chemerin and hs-CRP indicated a significant statistical difference between the serum and synovial fluids of osteoarthritis patients, individuals with intra-articular fractures, and the control group (p < .001). Post-hoc analyses showed statistically significant differences in all conditions except for hs-CRP levels between osteoarthritis patients and individuals with intra-articular fractures.Conclusion: Discovering ways to stop or slow down osteoarthritis is a matter of great concern. The findings on osteoarthritis indicate diverse, complex, and multidimensional processes involving cytokines. Information on cytokines that effect diseases can help develop efficient therapy methods.

show abstract

Section: Discussionmentioning

confidence: 99%

Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

Sarafan¹,

Fakoor²,

Mehdinasab³

et al. 2017

GJHS

View full text Add to dashboard Cite

show abstract

“…For instance, anti-TNF-α and anti-IL-17 autoantibodies were detected in RA patients. In addition, anti-IL-17A antibodies were associated with bone destruction and disease activity [9][10][11]. The generation of ACAAs was due to the loss of B cell tolerance caused by the overexpression of key inflammatory cytokines and chemokines [12].…”

Section: Introductionmentioning

confidence: 99%

Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients

Hong

Liu

Qiu

et al. 2022

Journal of Immunology Research

View full text Add to dashboard Cite

Cytokines like IL-17A have been consistently found to be elevated in psoriatic lesional skin, and therapeutic antibodies to IL-17 have demonstrated efficacy in treating psoriatic skin and joint disease. However, results about the circulating cytokines in psoriasis patients remained controversial. Anticytokine autoantibodies (ACAAs) were detected in various autoimmune diseases but remained largely unknown in psoriasis. We aimed to investigate the serum levels of cytokines and ACAAs in psoriasis patients. The study included 44 biologics-naive psoriasis patients and 40 healthy controls. Serum cytokines and the corresponding autoantibodies were measured by multiplex bead-based technology. The bioactivity of serum IL-17A was determined by IL-8 production in primary keratinocytes. Herein, we found serum levels of IL-12B (median: 6.16 vs. 9.03, p = 0.0194 ) and Th17 cytokines (IL-17A: median: 0.32 vs. 1.05, p = 0.0026 ; IL-22: median: 4.41 vs. 4.41, p = 0.0120 ) were increased in psoriasis patients. More interestingly, bioactive IL-17A was identified in a proportion of patients and positively correlated with disease severity. A few of cytokines were closely associated with each other and formed into a distinct panel in psoriasis. Of 13 anticytokine antibodies, anti-IL-22 was moderately lower (median: 262.8 vs.190.5, p = 0.0418 ), and anti-IL-15 was slightly higher (median: 25.5 vs. 30.5, p = 0.0069 ) in psoriasis than controls. None of ACAAs was related to disease severity. Consequently, the ratios of antibodies to cytokines varied with the pattern of cytokines. In summary, our finding suggested that the levels of circulating bioactive IL-17A were associated with disease activity in psoriasis patients. In contrast, the titers of ACAAs were not significantly altered nor correlated with disease severity. However, the functionality of ACAAs remains to be further demonstrated in vitro in future studies.

show abstract

Autoantibodies against interleukin-21 correlate with disease activity in patients with rheumatoid arthritis

Xing

Sun

et al. 2017

Clin Rheumatol

View full text Add to dashboard Cite

The objective of this study is to investigate the levels of interleukin (IL)-21 and autoantibodies (AAbs) against IL-21 and their association with clinical characteristics and laboratory parameters in patients with rheumatoid arthritis (RA). One hundred twenty-six patients with RA, 69 patients with osteoarthritis (OA), and 88 healthy controls (HC) were included in this study. The levels of IL-21 and AAbs against IL-21 in the serum were measured using enzyme-linked immunosorbent assay (ELISA). The correlation between the levels of IL-21 and anti-IL-21 AAbs with clinical and laboratory parameters was evaluated. The results showed that the concentration of IL-21 was significantly higher in the serum of patients with RA (15.58 ± 3.22 ng/ml) than OA (1.80 ± 0.99 ng/ml) and HC (0.07 ± 0.03 ng/ml, p < 0.01). The levels of IL-21 in the serum correlated with erythrocyte sedimentation rate (ESR) in patients with RA (r = 0.435, p < 0.01). Anti-IL-21 AAbs could be detected in RA patients. The median AU value of AAbs against IL-21 was significantly higher in serum of RA (47.90) than in that of OA (15.17) and HC (8.19, p < 0.01). The titers of AAbs against IL-21 correlated with Disease Activity Score-28 (DAS28) (r = 0.449, p < 0.001), ESR (r = 0.386, p < 0.001), and CRP (r = 0.241, p = 0.03). Both IL-21 and AAbs against IL-21 are elevated in RA. The levels of AAbs against IL-21 correlate with disease activity, which suggests that anti-IL-21 AAbs may play a role in the pathogenesis of RA.

show abstract

Elevated autoantibodies against interleukin‐17F correlate with disease activity in patients with early rheumatoid arthritis

Abstract: Elevated aAbs against IL-17F correlate with disease activity in patients with ERA. This evidence suggests that anti-IL-17F aAbs may have a protective role in the pathogenesis of ERA.

Cited by 3 publications

References 32 publications

Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

Post-Traumatic Arthritis: The Role of Cytokine Levels in Serum and Synovial Fluid

Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients

Autoantibodies against interleukin-21 correlate with disease activity in patients with rheumatoid arthritis

Contact Info

Product

Resources

About