Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection

Hsu, Chaur‐Dong; Meaddough, Erika; Aversa, Kristen; Hong, Shih-Fen; Lu, Li-Cheng; Jones, David; Copel, Joshua A.

doi:10.1016/s0002-9378(98)70144-9

Cited by 77 publications

(47 citation statements)

References 18 publications

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“…In the present study, 12 patients with clinical symptoms, such as cyclic uterine contraction, genital bleeding, rupture of membrane and cervical ripening, and who developed abortion and early preterm labor were diagnosed as severe intrauterine infection on histological examination of placentas, which were obtained after abortion or delivery. The concentrations of IL-6 and LE were signifi cantly elevated in their amniotic fl uid, consistent with previous studies [1][2][3][4][5][6] . However, in the present study it is diffi cult to explain the mechanisms by which infl ammatory cytokines could trigger myometrial activation and preterm rupture of membrane.…”

Section: Discussionsupporting

confidence: 91%

“…Many investigators have reported that an increase in the production of various cytokines might refl ect the host response to intrauterine infection in CAM at preterm delivery [1][2][3][4][5][6] . In the present study, 12 patients with clinical symptoms, such as cyclic uterine contraction, genital bleeding, rupture of membrane and cervical ripening, and who developed abortion and early preterm labor were diagnosed as severe intrauterine infection on histological examination of placentas, which were obtained after abortion or delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Many previous reports have documented elevation of infl ammatory substances [1,2] In the present study, we therefore investigated possible roles of NO in the pathological status in cases of chorioamnionitis. We thus assessed concentrations of NO, IL-6, and LE in amniotic fl uid obtained from patients complicated with severe CAM (16-25 weeks of gestation) and compared with women undergoing diagnostic amniocentesis in the early 2nd trimester (16-18 weeks of gestation).…”

Section: Introductionmentioning

confidence: 96%

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Reduced Nitric Oxide in Amniotic Fluid of Patients with Chorioamnionitis

Daoud

Suzuki²,

Yamamoto³

et al. 2005

Fetal Diagn Ther

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Objective: Levels of nitric oxide (NO) and cytokines were assessed in amniotic fluid obtained from patients with severe chorioamnionitis (CAM) and appropriate controls. Methods: Amniotic fluid was obtained from 12 patients with CAM (17–24 weeks of gestation) and 89 patients undergoing diagnostic amniocentesis (16–18 weeks of gestation). The concentrations of NO, interleukin-6 (IL-6), and leukocyte elastase (LE) in amniotic fluid were then measured and compared. Results: The concentrations of NO, IL-6, and LE were all higher in CAM cases than in normal pregnant women. Furthermore, an inverse correlation between NO and LE was suggested in the CAM group. Conclusions: These results indicate that in severe CAM, the action of NO might be reduced, not only due to blockage of action but also by degradation, despite increased production.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Reduced Nitric Oxide in Amniotic Fluid of Patients with Chorioamnionitis

Daoud

Suzuki²,

Yamamoto³

et al. 2005

Fetal Diagn Ther

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“…We have reported that i͞u administration of 120, 250, or 500 ng of EGF on d21 of pregnancy delayed the onset of labor in a dose-response fashion (10). The inflammatory cytokines have long been linked to i͞u infection-driven preterm labor (7,8,27,28), and there is accumulating evidence that they are also involved in normal term labor (29,30). In fact, it has been proposed that human parturition represents an inflammatory process.…”

Section: Discussionmentioning

confidence: 99%

“…This is consistent with the stimulatory action of EGF on amnion prostaglandins (PGs) biosynthesis, which has led to the suggestion of a role for EGF in parturition (5,6). At the time of delivery in women, some cytokines and growth factors are higher in amniotic fluid (AF) (7,8). Although EGF is sharply increased in AF near delivery, there is no effect of it on the timing of labor (9).…”

mentioning

confidence: 99%

Epidermal growth factor prevents prepartum luteolysis in the rat

Ribeiro¹,

Aisemberg²,

Billi³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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We have previously reported that intrauterine (i͞u) administration of epidermal growth factor (EGF 500 ng) on day (d) 21 of pregnancy delayed 19.0 ؎ 0.6 h the onset of labor. Progesterone (P) is secreted by ovarian corpora lutea (CL) throughout gestation in the rat. Prepartum CL regression due to increased uterine cyclooxygenase I and prostaglandin F 2␣ results in P withdrawal followed by labor. The aims of the present work were (i) to study whether EGF delayed-onset of labor was mediated by a mechanism that prevented CL regression; (ii) to determine amniotic fluid (AF) EGF in pregnant rats. Rats on d21 of pregnancy received i͞u EGF (500 ng) and were killed 0, 4, 8, 12, 24, and 48 h later. Control AF from rats on d13 and 18 -22 of pregnancy was obtained. EGF decreased uterine prostaglandin F 2␣ synthesis 8 h after treatment. Twelve hours after EGF injection, P reached its highest serum level and uterine cyclooxygenase I expression was undetectable. CL from rats killed 8 and 12 h after EGF were similar to those from rats on d13 of pregnancy, when serum P is maximum. EGF in AF increased throughout gestation, reached a maximum on d21, and decreased before the onset of labor. We suggest that the effect of EGF on the onset of labor was mediated by an early effect on the uterus that prevented prepartum CL regression.

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Effects of Interleukin-8 on the Developing Human Intestine

Maheshwari

Lacson

et al. 2002

Cytokine

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Elevated amniotic fluid levels of leukemia inhibitory factor, interleukin 6, and interleukin 8 in intra-amniotic infection

Cited by 77 publications

References 18 publications

Reduced Nitric Oxide in Amniotic Fluid of Patients with Chorioamnionitis

Reduced Nitric Oxide in Amniotic Fluid of Patients with Chorioamnionitis

Epidermal growth factor prevents prepartum luteolysis in the rat

Effects of Interleukin-8 on the Developing Human Intestine

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