Elevated alpha-fetoprotein in benign/borderline liver masses in children

Köse, Doğan

doi:10.5505/tjoncol.2015.1164

Cited by 1 publication

(2 citation statements)

References 6 publications

(13 reference statements)

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“…Another case of 11-monthold boy presenting with mesenchymal hamartoma had AFP levels of 3829 ng/mL. Dogan Kose et al [4] reported in the retrospective study done on 5 patients between 2006 and 2012 who were diagnosed with benign/ borderline liver masses that elevated AFP levels can be seen in benign liver masses and they can wrongly suggest malignant liver tumours. AFP levels were between 123 ng/mL and 4905 ng/mL in patients with median age of 6 months among whom 2 were diagnosed with haemangioendothelioma, 1 had mesenchymal hamartoma, 1 had haemangioma and 1 had focal nodular hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, AFP levels are also used as a marker for response to treatment, prognosis and to determine the outcome of malignant liver tumours. [3] However, Dogan et al [4] reported that benign liver conditions like haemangioendotheliomas, mesenchymal hamartomas, cases of hepatic insult and regeneration like hepatitis and cirrhosis also show increased AFP levels. AFP monitoring is vital in management of hepatic tumours.…”

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confidence: 99%

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Significance of Serum Alpha-Fetoprotein Levels in the Diagnosis and Prognosis of Paediatric Liver Tumours- A Study at Paediatric Referral Centre

Krishna¹,

Geetha²,

Fatima³

et al. 2018

jemds

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BACKGROUNDThere is a need for accurate diagnosis and preoperative evaluation of paediatric liver tumours, because treatment modalities and management protocols vary for benign and malignant tumours. There is a widespread notion that elevated AFP levels are suggestive of malignant liver tumours. However, in paediatric age group, serum AFP levels are normally higher than adults upto eight months of age. Preoperative evaluation involves radiology and serum AFP levels.So this study aims to study the AFP levels in both malignant and benign liver tumours and also understand if higher levels are seen in malignant liver tumours over their benign counterpart. MATERIALS AND METHODSA retrospective descriptive study of all the cases of paediatric liver tumours received at the Department of Pathology, Niloufer Hospital was done. Detailed clinical history, radiological investigations and serum AFP levels were recorded in all the cases. RESULTSThe hypothesis that benign paediatric liver tumours show normal-to-mildly elevated AFP levels did not correlate with our results. There was a very wide variation in elevation of AFP levels in all the cases. Both benign and malignant liver tumours showed similar percentage of elevation in AFP levels.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%