Elevated Adenosine Dehydrogenase (ADH) and Positive Tuberculin Test Firstly Misdiagnosed as Tuberculous Pleural Effusion Finally Proved as Pleural Mesothelial Sarcoma by Thoracoscopic Biopsy Pathology: a Case Report and Literature Review

Li, Wen Q; Fu, Ai S; Shao, Dong F; Zhang, Qian; Wang, Meng H; Wang, Hong Y; Chen, Yi; Zhang, Ci; Zhu, Xiao Jun; Ge, Yan L

doi:10.7754/clin.lab.2019.190323

Cited by 3 publications

(3 citation statements)

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“…However, it is not a specific index for differentiating between tuberculosis and cancer diagnoses. Although elevated ADA levels usually indicate tuberculosis, the non-specific characteristics of cancer patients presenting with increased ADA levels and a positive tuberculin test can lead to misdiagnosis ( 16 , 17 ).…”

Section: Laboratory Testsmentioning

confidence: 99%

“…The diagnosis of cancer is usually made based on histological analyses of excisional biopsies, fine-needle aspiration cytology, and liquid biopsy ( 16 ). Fine-needle aspiration cytology, a commonly used method that is minimally invasive, quick, and accurate, involves the use of a thin needle to acquire cellular material from a bodily lesion or mass for diagnostic purposes.…”

Section: Laboratory Testsmentioning

confidence: 99%

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Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass

Xiang

Huang

et al. 2021

Front. Oncol.

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Confusing masses constitute a challenging clinical problem for differentiating between cancer and tuberculosis diagnoses. This review summarizes the major theories designed to identify factors associated with misdiagnosis, such as imaging features, laboratory tests, and clinical characteristics. Then, the clinical experiences regarding the misdiagnosis of cancer and tuberculosis are summarized. Finally, the main diagnostic points and differential diagnostic criteria are explored, and the characteristics of multimodal imaging and radiomics are summarized.

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Section: Laboratory Testsmentioning

confidence: 99%

Section: Laboratory Testsmentioning

confidence: 99%

Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass

Xiang

Huang

et al. 2021

Front. Oncol.

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“…The reasons for "whoops" surgery include difficulty in clinically discriminating benign from malignant soft tissue masses [16]. Indeed, sarcomas can mimic lipoma, benign neurogenic tumor, certain infections, and thrombosis, among others [17][18][19][20][21]. Regardless, certain criteria suggestive of STS, including a size over 5 cm, tumor depth, recent growth, and pain, should lead to magnetic resonance imaging (MRI) assessment [20,22,23].…”

Section: Introductionmentioning

confidence: 99%

Shortening the Time Interval for the Referral of Patients With Soft Tissue Sarcoma to Expert Centers Using Mobile Health: Retrospective Study

Nannini¹,

Penel²,

Bompas³

et al. 2022

JMIR Mhealth Uhealth

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Background According to guidelines, all patients with sarcoma must be managed from initial diagnosis at expert sarcoma centers. However, in everyday practice, the time interval to an expert center visit can be long, which delays presentation to an expert multidisciplinary tumor board and increases the risk of inappropriate management, negatively affecting local tumor control and prognosis. The advent of mobile health offers an easy way to facilitate communication and cooperation between general health care providers (eg, general practitioners and radiologists) and sarcomas experts. We developed a mobile app (Sar’Connect) based on the algorithm designed by radiologists from the French Sarcoma Group. Through a small number of easy-to-answer questions, Sar’Connect provides personalized advice for the management of patients and contact information for the closest expert center. Objective This retrospective study is the first to assess this mobile app’s potential benefits in reducing the time interval for patient referral to an expert center according to the initial clinical characteristics of the soft tissue tumor. Methods From May to December 2021, we extracted tumor mass data for 78 patients discussed by the multidisciplinary tumor boards at 3 centers of the French Sarcoma Group. We applied the Sar’Connect algorithm to these data and estimated the time interval between the first medical description of the soft tissue mass and the referral to expert center. We then compared this estimated time interval with the observed time interval. Results We found that the use of Sar’Connect could potentially shorten the time interval to an expert center by approximately 7.5 months (P<.001). Moreover, for half (31/60, 52%) of the patients with a malignant soft tissue tumor, Sar’Connect could have avoided inappropriate management outside of the reference center. We did not identify a significant determinant for shortening the time interval for referral. Conclusions Overall, promoting the use of a simple mobile app is an innovative and straightforward means to potentially accelerate both the referral and management of patients with soft tissue sarcoma at expert centers.

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Shortening the Time Interval for Soft Tissue Sarcoma Patient Referral to Expert Centers: Application of mHealth for Rare Tumors (Preprint)

Nannini¹,

Penel²,

Bompas³

et al. 2022

Preprint

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BACKGROUND According to guidelines, all sarcoma patients must be managed from initial diagnosis at expert sarcoma centers. However, in everyday practice, the time interval to an expert center visit can be long, which delays presentation to an expert multidisciplinary tumor board (MTB) and increases the risk of inappropriate management, negatively affecting local tumor control and prognosis. The advent of mobile health (mHealth) offers an easy way to facilitate communication and cooperation between general health care providers (e.g., general practitioners and radiologists) and sarcomas experts. We developed a mobile application (Sar’Connect) based on the algorithm designed by radiologists from French Sarcoma Group. Through a small number of easy-to-answer questions, Sar’Connect provides personalized advice for management of patients and contact information on the closest expert center. OBJECTIVE This retrospective study is the first to assess this mobile application’s benefits in reducing the time interval for patient referral to an expert center according to the initial clinical characteristics of the soft tissue tumor. METHODS We extracted tumor mass data for 78 patients discussed by MTBs of three centers of French Sarcoma Group. We applied the Sar’Connect algorithm to these data and estimated the time interval to expert center referral; then, we compared this estimated time interval with the observed time interval. RESULTS We found that the use of Sar’Connect shortened the time interval to a referral center by approximately 7.5 months. Moreover, for half of patients with a malignant soft tissue tumor, Sar’Connect avoided inappropriate management outside of the reference center. We did not identify a significant determinant for shortening the time interval for referral. CONCLUSIONS Overall, promoting the use of a simple mobile application is an innovative and straightforward means to accelerating both the referral and management of soft tissue sarcoma patients in expert centers.

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Elevated Adenosine Dehydrogenase (ADH) and Positive Tuberculin Test Firstly Misdiagnosed as Tuberculous Pleural Effusion Finally Proved as Pleural Mesothelial Sarcoma by Thoracoscopic Biopsy Pathology: a Case Report and Literature Review

Cited by 3 publications

References 0 publications

Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass

Cancer or Tuberculosis: A Comprehensive Review of the Clinical and Imaging Features in Diagnosis of the Confusing Mass

Shortening the Time Interval for the Referral of Patients With Soft Tissue Sarcoma to Expert Centers Using Mobile Health: Retrospective Study

Shortening the Time Interval for Soft Tissue Sarcoma Patient Referral to Expert Centers: Application of mHealth for Rare Tumors (Preprint)

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