Eleusine indica L. possesses antioxidant activity and precludes carbon tetrachloride (CCl4)-mediated oxidative hepatic damage in rats

Iqbal, Mohammad; Gnanaraj, Charles

doi:10.1007/s12199-011-0255-5

Cited by 34 publications

(32 citation statements)

References 33 publications

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“…On the other hand solubility and stereochemical structure of inulin exposes the OH groups for interaction with fluoride ions. Differences in fluoride removal efficiencies of the sisal fibre, maize leaf, goosegrass, banana false stem and untreated sisal fibres (USF) may be attributed to the small and different proportions of steriochemically open and relatively soluble active compounds such as tannins and glycosides relative to cellulose in maize leaf, goosegrass, banana false stem and inulin relative to cellulose in untreated sisal fibres [33,34]. The presence of these compounds in the biomass is attributable to preparation procedures employed which did not involve removal of the water soluble impurities from the biomass.…”

Section: The Effect Of Solubility and Stereochemistry Of The Active Cmentioning

confidence: 99%

The Influence of Stereochemistry of the Active Compounds on Fluoride Adsorption Efficiency of the Plant Biomass

Mwakabona

Machunda

Njau

2014

AJCHE

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Several studies have reported various defluoridation capabilities of plant biomasses. The resultant variations in fluoride removal capacities are associated with the presence of different types of active functional groups in the respective biomasses. This study reports of the fluoride removal efficiencies of sisal leaf biomass in comparison. Comparison with other plant biomasses were made and hence the fluoride removal efficiencies of maize leaf (ML), goose grass (GG), banana false stem (BFS), Aloe vera (AV), untreated sisal fibre (USF) and sisal pith (SP) with similar active functional groups but different stereochemistry and solubility of the active compounds are reported. A portion of 0.5 g of each biomass was mixed with a 10 mg/l fluoride solution in a 10 ml portions under the same experimental conditions. The maximum fluoride removal capacity of sisal fibre biomass was found to be 26.6 %. By comparison, the fluoride removal efficiencies of ML, GG, BFS, AV, USF and SP were found to be, 4.1, 4.6, 7.1, 26.6, 29.4 and 47.3 % respectively. This suggests that, stereochemistry and solubility of the active compounds have a significant role to play in water defluoridation by plant biomasses, and thus, knowledge of the stereochemistry and solubility of the active compounds in plant biomass is very important to fully unlock biomass' defluoridation potentials.

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Section: The Effect Of Solubility and Stereochemistry Of The Active Cmentioning

confidence: 99%

The Influence of Stereochemistry of the Active Compounds on Fluoride Adsorption Efficiency of the Plant Biomass

Mwakabona

Machunda

Njau

2014

AJCHE

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“…The decoctions of the boiled whole plant are consumed for antihelminthic and febrifuge treatment [12]. The seed of E. indica is sometimes used as famine food and in the treatment for liver complaints [13]. …”

Section: Introductionmentioning

confidence: 99%

“…Several pharmacological properties on E. indica have been reported including hepatoprotective effect [13], antiplasmodial and antidiabetic [14], antioxidant and antimicrobial activity [8], anti-inflammatory [15], and cytotoxic effect towards several cancer cell lines [8, 16]. To date, only one study reported the isolation of secondary metabolites from E. indica where hexadecanoic acid and [[(2-aminoethoxy) hydroxyphosphinyloxy]methyl]-1,2–ethanediylester were isolated [17].…”

Section: Introductionmentioning

confidence: 99%

Porcine Pancreatic Lipase Inhibitory Agent Isolated from Medicinal Herb and Inhibition Kinetics of Extracts from Eleusine indica (L.) Gaertner

Ong

Mah

Lai

2016

Journal of Pharmaceutics

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Eleusine indica (Linnaeus) Gaertner is a traditional herb known to be depurative, febrifuge, and diuretic and has been reported with the highest inhibitory activity against porcine pancreatic lipase (PPL) among thirty two plants screened in an earlier study. This study aims to isolate and identify the active components that may possess high potential as an antiobesity agent. Of the screened solvent fractions of E. indica, hexane fraction showed the highest inhibitory activity of 27.01 ± 5.68% at 100 μg/mL. Bioactivity-guided isolation afforded three compounds from the hexane fraction of E. indica, namely, β-sitosterol, stigmasterol, and lutein. The structures of these compounds were elucidated using spectral techniques. Lutein showed an outstanding inhibitory activity against PPL (55.98 ± 1.04%), with activity 60% higher than that of the reference drug Orlistat. The other compounds isolated and identified were β-sitosterol (2.99 ± 0.80%) and stigmasterol (2.68 ± 0.38%). The enzyme kinetics of E. indica crude methanolic extract on PPL showed mixed inhibition mechanism.

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“…Positive results in all the antioxidant activity assays used in this study indicate that the various compounds in the crude extracts could act as free radicals’ scavenger viz., DPPH, ABTS, SOR or possess the reducing power potential of Fe 3+ , Cu 2+ and Mo (IV) complex. Devi and Kottai [ 42 ], Iqbal and Gnanaraj [ 51 ] and Rekha and Shivanna [ 52 ] also reported antioxidant activity in S. spontaneum, E. indica and D. aegyptium. Intake of such antioxidants protect the body from damage caused by harmful molecules such as free radicals, ultimately lowering the risk of infections and some forms of cancer and so, improves the health.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of biological potential of selected species of family Poaceae from Bahawalpur, Pakistan

Fatima

Kanwal

Mahmood

2018

BMC Complement Altern Med

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BackgroundOxidative stress as well as bacterial and fungal infections are common source of diseases while plants are source of medication for curative or protective purposes. Hence, aim of study was to compare the pharmacological potential of seven grass species in two different solvents i.e. ethanol and acetone.MethodsPreliminary phytochemical tests were done and antioxidant activities were evaluated using ELISA and their IC50 values and AAI (%) were recorded. ANOVA was used for statistical analyses. DNA damage protection assay was done using p1391Z plasmid DNA and DNA bands were analyzed. Antimicrobial activity was done via disc diffusion method and MIC and Activity Index were determined. Cytotoxic activity was carried out using the brine shrimps’ assay and LC50 values were calculated using probit analysis program.ResultsPhytochemical studies confirmed the presence of secondary metabolites in most of the plant extracts. Maximum antioxidant potential was revealed in DiAEE, DiAAE (AAI- 54.54% and 43.24%) and DaAEE and DaAAE (AAI- 49.13% and 44.52%). However, PoAEE and PoAAE showed minimum antioxidant potential (AAI- 41.04% and 34.11%). SaSEE, DiAEE and ElIEE showed very little DNA damage protection activity. In antimicrobial assay, DaAEE significantly inhibited the growth of most of the microbial pathogens (nine microbes out of eleven tested microbes) among ethanol extracts while DaAAE and ImCAE showed maximum inhibition (eight microbes out of eleven tested microbes) among acetone plant extracts. However, PoAEE and PoAAE showed least antimicrobial activity. F. oxysporum and A. niger were revealed as the most resistant micro-organisms. ImCEA and ImCAE showed maximum cytotoxic potential (LC50 11.004 ppm and 7.932 ppm) as compared to the other plant extracts.ConclusionFodder grasses also contains a substantial phenols and flavonoids contents along with other secondary metabolites and, hence, possess a significant medicinal value. Ethanol extracts showed more therapeutic potential as compared to the acetone extracts. This study provides experimental evidence that the selected species contains such valuable natural compounds which can be used as medicinal drugs in future.

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Eleusine indica L. possesses antioxidant activity and precludes carbon tetrachloride (CCl4)-mediated oxidative hepatic damage in rats

Abstract: The results of our study indicate that the hepatoprotective effects of E. indica might be ascribable to its antioxidant and free radical scavenging property.

Cited by 34 publications

References 33 publications

The Influence of Stereochemistry of the Active Compounds on Fluoride Adsorption Efficiency of the Plant Biomass

The Influence of Stereochemistry of the Active Compounds on Fluoride Adsorption Efficiency of the Plant Biomass

Porcine Pancreatic Lipase Inhibitory Agent Isolated from Medicinal Herb and Inhibition Kinetics of Extracts from Eleusine indica (L.) Gaertner

Evaluation of biological potential of selected species of family Poaceae from Bahawalpur, Pakistan

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