Eletriptan: a review and new perspectives

Sandrini, Giorgio; Perrotta, Armando; Nappi, Giuseppe

doi:10.1586/14737175.6.10.1413

Cited by 6 publications

(2 citation statements)

References 54 publications

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“…Ez a leglipofilebb triptán, jól tolerálható. Főleg a CYP3A4 izoenzim által metabolizálódik, N-demetil-eletriptan aktív metabolit keletkezik, gyakoribbak a KIR-i mellékhatások [66][67].…”

Section: Orvostudományi éRtesítőunclassified

Chemical and pharmacological characterization of triptans

Kelemen

Bíborka-Erzsébet

Attila

2019

Bulletin of Medical Sciences

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Triptans are specific drugs for migraine attack, their use leads to selective vasoconstriction, while the inflammatory condition that usually occurs during migraine is reduced. The structurally indolamine derivatives are selective agonists of the serotonin 1B/1D receptor. This review presents the history, representatives, production, and physico-chemical properties of triptans, but also discusses their pharmacological properties and mechanism of action.

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Section: Orvostudományi éRtesítőunclassified

Chemical and pharmacological characterization of triptans

Kelemen

Bíborka-Erzsébet

Attila

2019

Bulletin of Medical Sciences

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“…Eletriptan is a second-generation 5-HT 1B/1D receptor agonist indicated for the acute treatment of migraine (118). A case of serotonin syndrome and rhabdomyolysis induced by concomitant use of eletriptan, fluoxetine, and SJW has been reported in a 28-year-old woman (119).…”

Section: Antimigraine Drugsmentioning

confidence: 99%

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

Borrelli

Izzo

2009

AAPS J

236

190

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Abstract. St John's wort (SJW) extracts, prepared from the aerial parts of Hypericum perforatum, contain numerous pharmacologically active ingredients, including naphthodianthrones (e.g., hypericin and its derivatives), phloroglucinols derivatives (e.g., hyperforin, which inhibits the reuptake of a number of neurotransmitters, including serotonin), and flavonoids. Such extracts are widely used for the treatment of mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile. However, relevant and, in some case, life-threatening interactions have been reported, particularly with drugs which are substrate of cytochrome P450 and/or P-glycoprotein. Well-documented SJW interactions include (1) reduced blood cyclosporin concentration, as suggested by multiple case reports as well as by clinical trials, (2) serotonin syndrome or lethargy when SJW was given with serotonin reuptake inhibitors, (3) unwanted pregnancies in women while using oral contraceptives and SJW, and (4) reduced plasma drug concentration of antiretroviral (e.g., indinavir, nevirapine) and anticancer (i.e., irinotecan, imatinib) drugs. Hyperforin, which is believed to contribute to the antidepressant action of St John's wort, is also strongly suspected to be responsible of most of the described interactions.

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Generika in der Psychiatrie; Tiroler Psychologiepreis geht an Schulpsychologen Dr. Hans Henzinger; Ein breites Spektrum für die individuelle Therapie; Konsequente Frühtherapie mit Interferon beta-1b verbessert Langzeitprognose bei multipler Sklerose

2008

Psychopraxis

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Eletriptan: a review and new perspectives

Cited by 6 publications

References 54 publications

Chemical and pharmacological characterization of triptans

Chemical and pharmacological characterization of triptans

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

Generika in der Psychiatrie; Tiroler Psychologiepreis geht an Schulpsychologen Dr. Hans Henzinger; Ein breites Spektrum für die individuelle Therapie; Konsequente Frühtherapie mit Interferon beta-1b verbessert Langzeitprognose bei multipler Sklerose

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