Elemental Sulfur Promoted Cyclization of Aryl Hydrazones and Aryl Isothiocyanates Yielding 2-Imino-1,3,4-thiadiazoles
Tan N. Huynh,
Khanh T. N. Ong,
Phuong T. Dinh
et al.
Abstract:We report a method for using elemental
sulfur to facilitate
the
cyclization of aryl hydrazones and aryl isothiocyanates, affording
biorelated 2-imino-1,3,4-thiadiazoles. Reactions progressed in the
presence of elemental sulfur, N-methylmorpholine
base, and DMSO solvent, while were tolerant of a wide range of functionalities
including halogen, nitro, cyano, methylsulfonyl, and heterocyclic
groups. The method appears to offer a general pathway for using simple,
cheap, and stable reagents to afford triaryl-substi… Show more
: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic...
: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic...
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