Elemental composition of human milk from mothers of premature and full-term infants during the first 3 months of lactation

Friel, James K.; Andrews, Wayne; Jackson, Simon E.; Longerich, Henry P.; Mercer, Claude N.; Mcdonald, Allison C.; Dawson, Barbara; Sutradhar, Brajendra C.

doi:10.1007/bf02784423

Cited by 73 publications

(49 citation statements)

References 24 publications

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Section: Discussionsupporting

confidence: 93%

“…A study by Friel et al 1999 reported La content at around 5 μg L −1 which is consistent with our findings. Similar values were reported for Ce (Friel et al 1999), an element found below detection in the present study. Colostrum milk has been previously shown to contain significantly higher concentrations of various trace elements, including essential and toxic ones, than transitional or mature breast milk (Akanle et al 2001;Chao et al 2014).…”

Section: Discussionsupporting

confidence: 93%

“…At present, there is little data available; concentrations of a few elements of both groups (mostly Ce, La, Pt, and Sc) in human milk have previously been reported from studies conducted on a generally small sample size (Friel et al 1999). The present research was undertaken in an effort to broaden knowledge on REEs.…”

Section: Introductionmentioning

confidence: 99%

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Rare-earth elements in human colostrum milk

Poniedziałek

Rzymski

Pięt

et al. 2017

Environ Sci Pollut Res

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Rare-earth elements (REEs) are used in a growing number of applications, and their release to environment has increased over the decades. Knowledge of REEs in human milk and factors that could possibly influence their concentration is scarce. This study evaluated the concentrations of 16 REEs (Ce, Eu, Er, Gd, La, Nd, Pr, Sc, Sm, Dy, Ho, Lu, Tb, Tm, Y, and Yb) in human colostrum milk collected from Polish women (n = 100) with the ICP-OES technique. The concentrations (mean ± SD) of Pr (41.9 ± 13.2 μg L −1 ), Nd (11.0 ± 4.0 μg L −1 ), La (7.1 ± 5.2 μg L −1 ), and Er (2.2 ± 0.8 μg L −1 ) were found above detection limits. The total mean ± SD concentration of detected REEs was 60.9 ± 17.8 μg L −1 . Current smokers displayed significantly increased Nd concentrations compared to women who had never smoked. No other associations between REEs in colostrum milk and age, diet in pregnancy (food supplement use and frequency of fish, meat, and vegetable consumption) or place of living (urban/rural) were found. This study adds to general understanding of the occurrence and turnover of REEs in women and human fluids.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

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Rare-earth elements in human colostrum milk

Poniedziałek

Rzymski

Pięt

et al. 2017

Environ Sci Pollut Res

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“…Molybdenum concentrations of human milk appear to be highest during the first few days of breastfeeding, and decrease during the course of lactation (Dang et al, 1984;Casey and Neville, 1987;Bouglé et al, 1988;Aquilio et al, 1996;Krachler et al, 1998;Friel et al, 1999) (Appendix A). In mature human milk 6 from women in Europe, mean molybdenum concentrations were reported to range from 0.72 to 4 µg/L.…”

Section: Breast Milkmentioning

confidence: 99%

Scientific Opinion on Dietary Reference Values for molybdenum

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2013

EFSA Journal

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Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for molybdenum. Molybdenum is efficiently and rapidly absorbed at a wide range of intakes, and the body is able to maintain homeostasis through the regulation of excretion via the urine. Molybdenum deficiency in otherwise healthy humans has not been observed and there are no biomarkers of molybdenum status. Various metabolic balance studies have been performed to establish molybdenum requirements. However, only one balance study, which was performed with a constant diet and under controlled conditions in adult men, was considered to be of sufficient duration. In this small study, balance was reported to be near zero when molybdenum intakes were 22 µg/day. Biochemical changes or symptoms suggestive of molybdenum deficiency were not observed, and it is possible that humans may be able to achieve molybdenum balance at even lower intakes. Data on molybdenum intakes and health outcomes were unavailable for the setting of DRVs for molybdenum. As the evidence required to derive an Average Requirement and a Population Reference Intake was considered insufficient, an Adequate Intake (AI) is proposed. Observed molybdenum intakes from mixed diets in Europe were taken into consideration in setting this value. An AI of 65 µg/day is proposed for adults; a figure that is based on molybdenum intakes at the lower end of the wide range of observed intakes. It is suggested that the adult AI also applies to pregnant and lactating women. An AI is also proposed for infants from seven months and for children based on extrapolation from the adult AI using isometric scaling and the reference body weights of the respective age groups. Molybdenum is an essential component of certain enzymes that catalyse redox reactions and contain, in addition to molybdenum, other prosthetic groups such as flavin adenine dinucleotide or haem. In humans, sulphite oxidase, xanthine oxidoreductase, aldehyde oxidase and mitochondrial amidoxime reducing component require molybdenum linked with a pterin (molybdopterin) as the cofactor. These enzymes are involved in the metabolism of aromatic aldehydes and the catabolism of sulphurcontaining amino acids and heterocyclic compounds, including purines, pyrimidines, pteridins and pyridines. © EuropeanIn humans, a single case report of a syndrome suggestive of dietary molybdenum deficiency in a patient on total parenteral nutrition for several months has been reported, but clinical signs of molybdenum deficiency in otherwise healthy humans have not been observed. A distinct molybdenum deficiency syndrome has not been observed in animals when subjected to molybdenum restriction, despite considerable reduction in the activity of molybdoenzymes.Water-soluble molybdates are efficiently and rapidly absorbed from the digestive tract at a wide range of intakes, and the body is able to adapt to this wide intake range by regulating excretion via the urine. Storage of ...

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“…During lactation in rats, there is a 20-fold increase in transport of plasma copper to the mammary gland (Donley et al 2002). Copper concentrations in milk are high after birth (0.4-0.6 mg/liter in humans) but decrease during late lactation both in humans (0.2-0.3 mg/liter) (Perrone et al 1993;Lö nnerdal 1996;Wooten et al 1996;Friel et al 1999) and rodents (Linder et al 1998). The supply of copper to milk may be regulated by hormonal control of copper fluxes into and out of the mammary gland during lactation.…”

mentioning

confidence: 99%

ATP7B Expression in Human Breast Epithelial Cells Is Mediated by Lactational Hormones

Michalczyk

Bastow

Greenough

et al. 2007

J Histochem Cytochem.

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Mammary epithelial cells that produce milk are unique in containing both of the Cu pumps, ATP7A and B, central to mammalian copper homeostasis but otherwise found individually. We have begun studies to clarify their roles in this gland using confocal microscopy. ATP7B was expressed in the luminal epithelial cells of human breast tissue, with a perinuclear location that shifted to a diffuse location with lactation. In the human mammary epithelial cell culture model (PMC42), ATP7B was also in the perinuclear region and redistributed to endosomes adjacent to, but not coincident with, the apical plasma membrane after treatment of the cultures with a lactational hormone regimen (3 days estrogen and progesterone then 3 days insulin, dexamethasone, prolactin). ATP7B was in a different subset of vesicles from those containing milk proteins and did not overlap with endosomes containing ATP7A. A physiological concentration of extracellular Cu was required for the redistribution effect, suggesting it was caused indirectly by increased intracellular Cu concentrations. Overexpression of ATP7B in the PMC42 cultures, grown as polarized monolayers, resulted in an enhanced efflux of Cu from the apical cell surface (determined with 64Cu). Our findings are consistent with the concept that ATP7B is important for the secretion of copper from the mammary gland into the milk. Supported by PHS Grant No. RO1 HD 46949.

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Elemental composition of human milk from mothers of premature and full-term infants during the first 3 months of lactation

Cited by 73 publications

References 24 publications

Rare-earth elements in human colostrum milk

Rare-earth elements in human colostrum milk

Scientific Opinion on Dietary Reference Values for molybdenum

ATP7B Expression in Human Breast Epithelial Cells Is Mediated by Lactational Hormones

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