Elemental bioimaging of platinum in mouse tissues by laser ablation-inductively coupled plasma-mass spectrometry for the study of localization behavior of structurally similar complexes

Lum, Judy Tsz-Shan; Ho, Cheuk Lam; Tsoi, Yeuk-Ki; Siu, Chi-Ho; Yue, Patrick Ying-Kit; Wong, Wai Yeung; Leung, Kelvin Sze-Yin

doi:10.1016/j.ijms.2016.05.005

Cited by 18 publications

(7 citation statements)

References 36 publications

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“…Lum et al 193 synthesized two chemically distinct Pt complexes (Pt1 and Pt2) and used a combination of ICP-MS bulk analysis and LA-ICP-MS imaging to determine the relative bioavailability of the complexes compared against cisplatin in various organs following intraperitoneal injection in mice. The animals were euthanized 24 h post administration, and representative samples of brain, heart, lung, liver, kidney, and testis were bulk analyzed for Pt by digestion and ICP-MS analysis, while the kidney and the liver were imaged by LA-ICP-MS to examine the spatial distributions of Pt.…”

Section: Cancermentioning

confidence: 99%

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

et al. 2021

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Elemental imaging gives insight into the fundamental chemical makeup of living organisms. Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements that define structure and function. Many disease states feature a disturbance in elemental homeostasis, and understanding how, and most importantly where, has driven the development of laser ablation−inductively coupled plasma−mass spectrometry (LA-ICP-MS) as the principal elemental imaging technique for biologists. This review provides an outline of ICP-MS technology, laser ablation cell designs, imaging workflows, and methods of quantification. Detailed examples of imaging applications including analyses of cancers, elemental uptake and accumulation, plant bioimaging, nanomaterials in the environment, and exposure science and neuroscience are presented and discussed. Recent incorporation of immunohistochemical workflows for imaging biomolecules, complementary and multimodal imaging techniques, and image processing methods is also reviewed.CONTENTS

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Section: Cancermentioning

confidence: 99%

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

et al. 2021

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“…After impregnation, the catalysts were dried at 393 K overnight and calcined under airflow at 723 K during 2 hours. This kind of preparation leads to egg-shell distribution of Pd and then a strong concentration gradient from the border to the center of the beads [18]. The targeted Pd loading was 0.4 wt%.…”

Section: Samplesmentioning

confidence: 99%

“…This result is strictly quantitative and statistical measurements uncertainties can be associated. It can be used to understand and model the impregnation processes as well as predict the catalyst performance [18] or do quality control of their production (heterogeneity of batches). …”

Section: Averaged Distribution Profilesmentioning

confidence: 99%

“…Acquisition rate of up to kHz has already been demonstrated [16]. Its high acquisition speed combined with its full compatibility with optical microscopy provide LIBS unique features compared to other elemental imaging methods such as laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) [17][18][19], synchrotron radiation microanalysis (SXRF) [20][21][22][23][24], and electron probe micro-analysis (EPMA) [21,25,26]. Although these "gold standard" techniques may have a better sensitivity or spatial resolution, their relatively slow operation speed (generally limited to ∼1 Hz/pixel) makes LIBS very attractive for applications requiring fast imaging, 3D characterization and/or large-scale analysis.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative elemental imaging of heterogeneous catalysts using laser-induced breakdown spectroscopy

Trichard

Sorbier

Moncayo

et al. 2017

Spectrochimica Acta Part B: Atomic Spectroscopy

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Nowadays, the use of catalysis is implied in almost all industrial process. Their use allows improving productivity, synthesis yields and waste treatment as well as decreasing the energy costs. The increasingly stringent requirements in terms of reaction selectivity and environmental standards impose an ever more accurate knowledge and control of their operations. However, the characterization techniques struggle to develop and often require equipment with high complexity.In this paper, we demonstrate a novel elemental approach with an all-optical design allowing quantitative space-resolved analysis to be performed with ppm-scale limit of quantification and µm-scale resolution. This approach, based on laser-induced breakdown spectroscopy (LIBS), is distinguished by its simplicity of use, all-optical design, and speed of operation. This work was conducted on palladium-based porous alumina catalyst, used for the selective hydrogenation process in the field of petrochemistry. We report an exhaustive study on the quantification capability of this technique with the possibility to perform imaging measurement over a large dynamical range, typically from few ppm to %. These results offer new insight into the use of LIBS imaging in the industry and paves the way for innumerable applications.2

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“…Fundamental research focusing on the photophysical and chemical properties of platinum complexes has been strongly stimulated by their potential applications: in particular, as emitters for organic light-emitting diodes (OLEDs), − for bioimaging, , and as anticancer agents . The structure–property relationships of emissive cyclometalated Pt complexes have been extensively investigated .…”

Section: Introductionmentioning

confidence: 99%

Dual-Emissive Bis(diphenylphosphino)amine Platinum Complexes: Structural, Reactivity, Photophysical, and Theoretical Investigations

et al. 2020

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By the reactions of bis(diphenylphosphino)amine (dppa) with equimolar amounts of cycloplatinated(II) complexes 1 with two neutral (SMe 2 or DMSO) and anionic (Cl − or CF 3 CO 2 − ) labile ligands the bis-chelate complexes 2 with a chelating mode of dppa were synthesized that have one of the smallest bite angles in a diphosphine. As the usual strategy for synthesizing the binuclear complexes, the reactions of 0.5 equiv of dppa with cycloplatinated(II) complexes 1 with a Cl − ligand were successful in making symmetrical binuclear complexes. Also, the chelating dppa has a strong angle strain that makes it a susceptible precursor for biphosphine ring opening. Furthermore, this new strategy was successful for designing symmetrical and unsymmetrical binuclear complexes with Cl − ligands. Interestingly, all efforts to make binuclear complexes with bridging dppa from precursors that contain CF 3 CO 2 − were unsuccessful by both strategies. The effects of dimerization via a change in the coordination mode of dppa, from a chelate mode in complexes 2 with green emission to a bridge mode in complexes 3, with dualphosphorescence red emission were investigated in the powder and poly(methyl methacrylate) (PMMA) phases at 77 and 298 K. The emission decay curves of all complexes in the solid state show long and short lifetime values as characteristics of the triplet excited states. The reaction pathway, reactivity, and structural aspects of the complexes were compared with those of other similar dppm analogues and the mechanism of conversion via possible intermediates was considered by density functional theory (DFT) calculations. For interpretation of the emission spectra, time-dependent DFT (TD-DFT) calculations were carried out on the isolated and stacked forms.

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Elemental bioimaging of platinum in mouse tissues by laser ablation-inductively coupled plasma-mass spectrometry for the study of localization behavior of structurally similar complexes

Cited by 18 publications

References 36 publications

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

Quantitative elemental imaging of heterogeneous catalysts using laser-induced breakdown spectroscopy

Dual-Emissive Bis(diphenylphosphino)amine Platinum Complexes: Structural, Reactivity, Photophysical, and Theoretical Investigations

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