Elemental analysis of urinary calculi by laser induced plasma spectroscopy

Fang, Xiaobin; Ahmad, S. R.; Mayo, Mike; Iqbal, Syed Tanweer

doi:10.1007/s10103-005-0356-8

Cited by 38 publications

(17 citation statements)

References 21 publications

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“…Fang et al 290 used the LIBS technique to analyze and identify elemental constituents of urinary calculi. The results showed that the elements detected with this study were: Ca, Mg, Na, Sr, K and Pb.…”

Section: Medical and Biological Applicationsmentioning

confidence: 99%

Laser Induced Breakdown Spectroscopy

Pasquini¹,

Cortez²,

Silva³

et al. 2007

J. Braz. Chem. Soc.

341

195

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Esta revisão descreve os aspectos fundamentais, a instrumentação, as aplicações e tendências futuras de uma técnica analítica que se encontra em seu estágio de consolidação e que está em vias de estabelecer o seu nicho entre as técnicas espectrofotométricas modernas. A técnica é denominada Espectroscopia de Emissão em Plasma Induzido por Laser (em inglês, Laser Induced Breakdown Spectroscopy, LIBS) e sua principal característica está no uso de pulsos de laser como fonte de energia para vaporizar a amostra e excitar a emissão de radiação eletromagnética, a partir de seus elementos e/ou fragmentos moleculares. A radiação emitida é analisada por meio de instrumentos ópticos de alta resolução e as suas intensidades são medidas, usualmente com detectores rápidos de estado sólido. Em conjunto, esses dispositivos permitem a geração e a medida de um espectro de emissão de faixa ampla do fenômeno induzido pelo pulso de laser. O espectro registrado contém informação qualitativa e quantitativa que pode ser correlacionada com a identidade da amostra ou empregada na determinação da quantidade de seus constituintes. Essa revisão é dividida em quatro partes. A primeira aborda aspectos históricos da técnica e os conceitos teóricos relevantes associados com LIBS; então, os aspectos práticos de diversas abordagens experimentais e instrumentais empregadas na implementação da técnica são revistos de forma crítica; as aplicações encontradas na literatura, incluindo aquelas que empregam quimiometria, são classificadas e exemplificadas por meio de trabalhos relevantes recentemente publicados. Finalmente, uma tentativa de estabelecer uma avaliação global e as perspectivas futuras para a técnica é apresentada.This review describes the fundamentals, instrumentation, applications and future trends of an analytical technique that is in its early stages of consolidation and is establishing its definitive niches among modern spectrometric techniques. The technique has been named Laser Induced Breakdown Spectroscopy (LIBS) and its main characteristic stands in the use of short laser pulses as the energy source to vaporize samples and excite the emission of electromagnetic radiation from its elements and/or molecular fragments. The emitted radiation is analyzed by high resolution optics and the intensities are recorded, usually by fast triggered solid state detectors. Together, these devices allow producing and registering a wide ranging emission spectrum of the short-lived phenomenon induced by the laser pulse. The spectrum contains qualitative and quantitative information which can be correlated with sample identity or can be used to determine the amount of its constituents. This review is divided in four parts. First, the relevant historical and theoretical concepts associated with LIBS are presented; then the main practical aspects of the several experimental and instrumental approaches employed for implementation of the technique are critically described; the applications related in the literature, including those making use of chemometri...

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Section: Medical and Biological Applicationsmentioning

confidence: 99%

Laser Induced Breakdown Spectroscopy

Pasquini¹,

Cortez²,

Silva³

et al. 2007

J. Braz. Chem. Soc.

341

195

View full text Add to dashboard Cite

show abstract

“…Fang et al [17] reported the first use of LIBS for urinary stone analysis. They analyzed seven urinary stone samples using both LIBS and Fourier transform infrared spectroscopy.…”

Section: Discussionmentioning

confidence: 99%

“…The findings of the present study support the results of the above-mentioned studies with respect to the reliability of LIBS. Furthermore, we used XRD for comparison, and our study had a larger number of patients than did that of Fang et al [17] Laser-induced breakdown spectroscopy has some advantages that make it a useful technique. One of these advantages is that prior sample preparation is not necessary, [17] while it is required for XRD and IRS.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, we used XRD for comparison, and our study had a larger number of patients than did that of Fang et al [17] Laser-induced breakdown spectroscopy has some advantages that make it a useful technique. One of these advantages is that prior sample preparation is not necessary, [17] while it is required for XRD and IRS. [18] Analysis using LIBS is easy and rapid.…”

Section: Discussionmentioning

confidence: 99%

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Laser-induced breakdown spectroscopy is a reliable method for urinary stone analysis

Mutlu

Çiftçi

Gülecen

et al. 2016

Turkish Journal of Urology

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Objective: We compared laser-induced breakdown spectroscopy (LIBS) with the traditionally used and recommended X-ray diffraction technique (XRD) for urinary stone analysis. Material and methods:In total, 65 patients with urinary calculi were enrolled in this prospective study. Stones were obtained after surgical or extracorporeal shockwave lithotripsy procedures. All stones were divided into two equal pieces. One sample was analyzed by XRD and the other by LIBS. The results were compared by the kappa (κ) and Spearman's correlation coefficient (rho) tests.Results: Using LIBS, 95 components were identified from 65 stones, while XRD identified 88 components. LIBS identified 40 stones with a single pure component, 20 stones with two different components, and 5 stones with three components. XRD demonstrated 42 stones with a single component, 22 stones with two different components, and only 1 stone with three different components. There was a strong relationship in the detection of stone types between LIBS and XRD for stones components (Spearman rho, 0.866; p<0.001). There was excellent agreement between the two techniques among 38 patients with pure stones (κ index, 0.910; Spearman rho, 0.916; p<0.001). Conclusion:Our study indicates that LIBS is a valid and reliable technique for determining urinary stone composition. Moreover, it is a simple, low-cost, and nondestructive technique. LIBS can be safely used in routine daily practice if our results are supported by studies with larger numbers of patients.

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“…LIBS has been utilized to elementally characterize removed gallstones [25,26], kidney stones [27], and other urinary calculi (stones [28]). Rather than possessing a common composition, all of these stones occur in a wide variety of elemental concentrations and compositions, each uniquely identifiable via LIBS analysis.…”

Section: Dental/mineralized Tissuesmentioning

confidence: 99%

Laser-induced breakdown spectroscopy (LIBS): an overview of recent progress and future potential for biomedical applications

Rehse

Salimnia

Miziolek

2012

Journal of Medical Engineering & Technology

167

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The recent progress made in developing laser-induced breakdown spectroscopy (LIBS) has transformed LIBS from an elemental analysis technique to one that can be applied for the reagentless analysis of molecularly complex biological materials or clinical specimens. Rapid advances in the LIBS technology have spawned a growing number of recently published articles in peer-reviewed journals which have consistently demonstrated the capability of LIBS to rapidly detect, biochemically characterize and analyse, and/or accurately identify various biological, biomedical or clinical samples. These analyses are inherently real-time, require no sample preparation, and offer high sensitivity and specificity. This overview of the biomedical applications of LIBS is meant to summarize the research that has been performed to date, as well as to suggest to health care providers several possible specific future applications which, if successfully implemented, would be significantly beneficial to humankind.

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Elemental analysis of urinary calculi by laser induced plasma spectroscopy

Cited by 38 publications

References 21 publications

Laser Induced Breakdown Spectroscopy

Laser Induced Breakdown Spectroscopy

Laser-induced breakdown spectroscopy is a reliable method for urinary stone analysis

Laser-induced breakdown spectroscopy (LIBS): an overview of recent progress and future potential for biomedical applications

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