Elemental analysis of the thyroid by laser induced breakdown spectroscopy

Ahmed, Irfan; Ahmed, Rafay; Yang, Jingwei; Law, Anthony; Zhang, Yanpeng; Lau, Condon

doi:10.1364/boe.8.004865

Cited by 24 publications

(12 citation statements)

References 21 publications

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“…Lithium may enter through the sodium/potassium ion channel as they all exist as positive ions. Accumulation of lithium ions in the follicular cell may limit the iodide influx from the blood vessel to the cell [ 24 ] and increases the sodium and potassium ion concentration [ 25 ]. This reduction of iodine due to accumulation of lithium may be related to tyrosine increase with lithium treatment [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Rapid and in situ optical detection of trace lithium in tissues

Ahmed

Yang

Law

et al. 2018

Biomed. Opt. Express

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Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer’s disease. However, the therapeutic mechanisms are not well characterized due to limitations in detecting lithium in organs and cells. This limits the ability to improve lithium-based treatments. To address this need, laser-induced breakdown spectroscopy (LIBS) is developed for the rapid and in situ detection of lithium in biological tissues. Pronounced lithium emissions are observed at 670.7nm from the rat thyroid, salivary, and mammary glands when lithium is administered orally. Calcium, carbon, magnesium, sodium, potassium, and iodine emissions are also observed. The lithium emission intensity is positively correlated with tissue lithium concentration, which is ~1ppm. The limit of detection for lithium is determined to be ~0.1ppm. Thyroid lithium intensity increases while iodine intensity decreases. The reduced intrathyroidal iodine following treatment likely impairs hormone production. Further, the presence of lithium in the salivary and mammary glands makes these glands the likely conduits for lithium to enter the saliva and breast milk, respectively. LIBS is well suited for characterizing the distribution of lithium, and other elements, across the body. This optical method can potentially be adapted for use in vivo and in humans.

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Section: Resultsmentioning

confidence: 99%

Rapid and in situ optical detection of trace lithium in tissues

Ahmed

Yang

Law

et al. 2018

Biomed. Opt. Express

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“…The methods described in the present study could be used clinically or in research applications as a post-implantation assay to determine immune response, inflammation, or silicon probe degradation and silicon infusion into the brain. The main advantages of our protocol include robust elemental analysis of biologically relevant states (Ahmed et al, 2017;Ahmed et al, 2018a;Ahmed et al, 2018b;, in addition to easy and consistent sample preparation. For example, in our recent study (Tsui et al, 2020), we measured different single red blood cell (RBC) morphology as induced by titanium dioxide (TiO2) nanoparticle administration.…”

Section: Discussionmentioning

confidence: 99%

“…In brief (Ahmed et al, 2017;Ahmed et al, 2018a;Ahmed et al, 2018b;, a 1064 nm pulse laser (CFR200, Quantel) emitting an 8 ns, 200 mJ pulse focused to a 10 μm spot was utilized for LIBS. All spectroscopic analysis was performed in standard atmospheric air.…”

Section: Laser Induced Breakdown Spectroscopy Of Probe Disintegration and Localizationmentioning

confidence: 99%

“…The main advantages of LIBS are easy sample preparation and effective spectroscopic elemental analysis of tissue samples. We have recently assessed a variety of tissues using LIBS coupling other techniques to determine elemental content during different biologically relevant states such as the effect of coffee on dental enamel (Ahmed et al, 2017;Ahmed et al, 2018a;Ahmed et al, 2018b;.…”

Section: Introductionmentioning

confidence: 99%

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Glymphatic clearance of simulated silicon dispersion in mouse brain analyzed by laser induced breakdown spectroscopy

Khan

Kumar

Manno

et al. 2020

Heliyon

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Silicon-based devices, such as neural probes, are increasingly used as electrodes for receiving electrical signals from neural tissue. Neural probes used chronically have been known to induce inflammation and elicit an immune response. The current study detects and evaluates silicon dispersion from a concentrated source in the mouse brain using laser induced breakdown spectroscopy. Element lines for Si (I) were found at the injection site at approximately 288 nm at 3hr post-implantation, even with tissue perfusion, indicating possible infusion into neural tissue. At 24hr and 1-week post-implantation, no silicon lines were found, indicating clearance. An isolated immune response was found by CD68 macrophage response at 24hr post injection. Future studies should measure chronic silicon exposure to determine if the inflammatory response is proportional to silicon administration. The present type of protocol, coupling laser induced breakdown spectroscopy, neuroimaging, histology, immunohistochemistry, and determination of clearance could be used to investigate the glymphatic system and different tissue states such as in disease (e.g. Alzheimer's).

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“…The LIBS technique has been a useful tool to discriminate and differentiate elements accurately with high spatial resolution [27]. Additionally, LIBS is used for the identification of elements in soft tissues [28][29][30][31] and mineralized tissues without invasive sampling preparation [32][33][34][35][36]. In the present study, we have quantified the variation of inorganic elements in teeth subjected to hot tea and cold tea (room temperature-RT) in an and analysis, decision to publish, or preparation of the manuscript.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic and microscopic examination of teeth exposed to green tea at different temperatures

Manno

Tian

et al. 2020

PLoS ONE

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Tea is a popular beverage consumed at different temperatures. The effect of tea on teeth at different temperatures has not been studied previously. The present study used an in vitro green tea immersed tooth model at different tea temperatures (hot and cold) compared to an in vivo tea administration model allowing rats to drink tea over the course of a week. The elements present in tea leaves were identified by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and compared to the elements in teeth (enamel surface) using Laser-Induced Breakdown Spectroscopy (LIBS). Here, LIBS demonstrated in vivo and in vitro green tea treatments resulted in a significant increase in the mineral elements found in enamel. For the in vitro assessment, elements in enamel varied based on cold-tea and hot-tea treatment; however, hot water reduced the elements in enamel. Atomic force microscopy found the in vivo tea group had a higher roughness average (RA) compared with the in vivo water group. Cold tea and hot tea in vitro groups demonstrated lower RA than in vitro water controls. Scanning electron microscopy found hot water induced cracks more than 1.3μm in enamel while cold tea and hot tea promoted the adhering of extrinsic matter to teeth. Overall, teeth treated to high temperature lost the mineral phase leading to demineralization. Our results indicate that green tea protects enamel, but its protective action in dental structures is enhanced at cold temperature.

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Elemental analysis of the thyroid by laser induced breakdown spectroscopy

Cited by 24 publications

References 21 publications

Rapid and in situ optical detection of trace lithium in tissues

Rapid and in situ optical detection of trace lithium in tissues

Glymphatic clearance of simulated silicon dispersion in mouse brain analyzed by laser induced breakdown spectroscopy

Spectroscopic and microscopic examination of teeth exposed to green tea at different temperatures

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