Element distributions and quantitative analysis of a single cell by micro-PIXE and synchrotron radiation XRF

Determination of the elemental composition of tissues of the cardiovascular system by atomic spectrometry, mass spectrometry and X-ray spectrometry methods

“…Later, develop ment of such methods as ICP MS, electron probe microanalysis, SXRF and PIXE has led to the appear ance of the data concerning the investigation of the elemental composition and distribution of elements by different heart compartments, heart and aorta valves, vessels [35,49,88] and the investigation of intracellu lar elemental composition and distribution of ele ments in myocardium [31,138,143,148,152].…”

“…For the investigation of the biological samples, including myocardium tissue, frequently used meth ods are X ray microanalysis [138][139][140][141][142][143][144] and PIXE [31,118,[145][146][147][148][149] which provide information on the dis tribution of chemical elements in the tissues and in the cell either. For example, in [143] X ray microanalysis provided the determination of intracellular concentra tion of Mg 2+ ion in the cells of aorta smooth muscles and in the cells of striated heart muscles in rats suffer ing from hypertension.…”