Elektrophysiologie in der Augenheilkunde

Abstract

Electrophysiology is an objective functional test of the visual pathway and allows the location of visual dysfunctions to be detected. The flash electroretinogram (ERG) allows recognition of large area damage to the retina and can distinguish between rod and cone diseases by recording under both dark and light-adapted conditions. Specific stimulation techniques are used for the multifocal ERG (mfERG) which reveals localized retinal dysfunction, e. g. in maculopathies. The pattern ERG (PERG) is an indicator of ganglion cell function and can be used for early detection of glaucoma. The visual evoked potential (VEP) is a cortical response and serves as a functional test of the entire visual pathway from the eye to the visual system of the brain. After presenting each of these methods individually, the article gives assistance in situations where the appropriate electrophysiological method for a given clinical hypothesis is to be selected and explains how the methods can be combined in a reasonable way.

Interferon Regulatory Factor 3 Deficiency Induces Age-Related Alterations of the Retina in Young and Old Mice

“…Electroretinogram is one of the most efficient electrophysiological techniques for detecting retinal function (Perlman, 1995; Meigen, 2015). We explored the effect of IRF3 deficiency on retinal function by ERG.…”