Elektronenmikroskopische Untersuchungen der Skelettmuskulatur bei terminaler Niereninsuffizienz

Bundschu, H. D.; Schlote, W.

doi:10.1016/0022-510x(74)90228-7

Cited by 14 publications

(8 citation statements)

References 8 publications

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“…Ultrastructural examination of degenerating and atro phic fibers showed filamentous dissolution and disap pearance similar to changes reported by Bundschu and Scholte [35] for muscle biopsies from patients with chronic renal failure. Some of these atrophic fibers con tained accumulations of heterogeneous, irregular bodies with the ultrastructural appearance of tertiary lysosomes ( fig.…”

Section: Discussionsupporting

confidence: 58%

Evaluation of the Effect of Intravenous <i>L</i>-Carnitine Therapy on Function, Structure and Fatty Acid Metabolism of Skeletal Muscle in Patients Receiving Chronic Hemodialysis

Siami

Clinton

Mrak

et al. 1991

Nephron

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Chronic hemodialysis (HD) leads to significant losses of carnitine from plasma and muscle. Because L-carnitine is important in the production of energy from fatty acid oxidation (FAO) in muscle, we examined the role of carnitine replacement by administering therapeutic doses of intravenous carnitine to 14 male patients receiving HD. Placebo or carnitine was given 2 g i.v. 3 times weekly for 6 months in a double-blind manner. To evaluate long-term toxicity of carnitine, all patients subsequently received 1 g i.v. carnitine for 10 months. Patients were rated for muscle strength each week. After 6 months, definite improvement in strength occurred in 4 of 7 carnitine-treated patients and in none of 7 controls. During the subsequent 10 months of carnitine administration, no adverse effects were noted and muscle strength improved in 9 of 14 patients. Muscle biopsy was performed in 13 patients before and after the first 6 months of treatment and in 6 healthy controls. FAO and carnitine were measured in each muscle biopsy. FAO was significantly lower in both carnitine- and placebo-treated HD patients compared to healthy controls. Although carnitine therapy increased the muscle concentration of carnitine 3-fold in muscle of HD patients, muscle FAO did not increase significantly and never reached the level of healthy controls. Muscle histopathology and ultrastructure were not specific for HD myopathy. Carnitine may be useful in treating some patients with muscle weakness related to HD.

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Section: Discussionsupporting

confidence: 58%

Evaluation of the Effect of Intravenous <i>L</i>-Carnitine Therapy on Function, Structure and Fatty Acid Metabolism of Skeletal Muscle in Patients Receiving Chronic Hemodialysis

Siami

Clinton

Mrak

et al. 1991

Nephron

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“…For the following four reasons the changes in muscle structure in our patient population were mostly due to glucocorticoid treatment rather than to the anamnestic uremia. (23)(24)(25)(26)(27). In most of the histologically analyzed biopsies from uremic patients, typical myopathic changes, not present in our patients treated with prednisone, could be detected (increased number ofcentral nuclei ofmuscles fibers [23,24,26,27], myelin figures [24,25,27], autophagic vacuoles [20], disrupted filaments [23,24,27] and increased lipofusion [23,27]).…”

Section: Discussionmentioning

confidence: 99%

“…For ethical reasons it was not possible to perform several biopsies in the same subject. Note that in the past a great number of investigations using single biopsy specimens from the thigh muscle have been performed in normal subjects and patients, assuming that the muscle biopsy is a representative sample of the thigh muscle (9,18,(23)(24)(25)(26)(27). (b) The assessment of the size of the muscle fibers and their intracellular components by electron microscopy has to be performed ex vivo after fixation ofthe tissue.…”

Section: Discussionmentioning

confidence: 99%

Impact of physical training on the ultrastructure of midthigh muscle in normal subjects and in patients treated with glucocorticoids.

Horber¹,

Hoopeler²,

Scheidegger³

et al. 1987

J. Clin. Invest.

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Exercise-training might be a logical method to reverse muscle atrophy and weakness in patients treated with glucocorticoids. The purpose of the present investigation was to establish whether a treatment with low dose prednisone (10±2.9 mg/d) modulates the effect of a moderate strength type isokinetic training during 7 wk (21 sessions of 20 min) on "muscle efficiency" (power output/muscle mass) and on concomitant changes in ultrastructure of the thigh muscle measured by quantitative electron-microscopic morphometry. Training caused a similar increase in "muscle efficiency" in patients on prednisone (a = 9) as in normal volunteers (a = 9). In normal subjects the increase in muscle efficiency was associated with an increase in sarcoplasm, whereas in patients on prednisone the functional improvement was associated with an increase in sarcoplasm, capillaries, and mitochondria content. Thus, a therapy with low dose prednisone does not abrogate training-induced improvement of muscle efficiency but modulates the ultrastructural response of the muscle to the trinng.

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“…f I ^HERE is strong evidence that 1,25-dihydroxyvi-X tamin D 3 [1,25-(OH) 2 D 3 ], the most biologically active form of vitamin D, influences muscle function (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Receptors for 1,25-(OH) 2 D 3 have been demonstrated in cultured human muscle cells (13,14).…”

mentioning

confidence: 98%

“…Receptors for 1,25-(OH) 2 D 3 have been demonstrated in cultured human muscle cells (13,14). Decreased muscle strength (usually characterized by proximal muscle atrophy and a selective loss of type II muscle fibers) is a well documented symptom of vitamin D deficiency (1)(2)(3)(4)(5)(6)(7)(8)(9)12) and administration of 1,25-(OH) 2 D 3 to patients with 1,25-(OH) 2 D3 deficiency restores muscle strength (6,(8)(9)(10)(11).…”

mentioning

confidence: 99%

1,25-Dihydroxyvitamin D₃and Muscle Strength in the Elderly: A Randomized Controlled Trial*

Grady

Halloran

Cummings

et al. 1991

The Journal of Clinical Endocrinology & Metabolism

100

103

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An unexplained loss of muscle strength occurs with aging. Vitamin D deficiency can cause myopathy and administration of 1,25-dihydroxyvitamin D3 [1,25-(OH2)D3] to persons with low serum concentrations can improve strength. To test the hypothesis that the weakness associated with aging is in part due to inadequate serum concentrations of [1,25-(OH2)D3], we conducted a randomized, controlled, double blinded trial in 98 men and women volunteers over 69 yr old. Treatment consisted of 0.25 micrograms 1,25-(OH)2D3, orally, twice per day or identical placebo for 6 months. Leg muscle strength of the quadriceps was measured with an isokinetic dynamometer. There was no difference between the two groups at 1 week, 1 month, or 6 months of treatment in any of the measures of muscle strength. We conclude that oral administration of 0.5 micrograms 1,25-(OH)2D3/day does not improve muscle strength in older persons. Further research is needed to determine the etiology of the decline in muscle strength associated with aging.

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Elektronenmikroskopische Untersuchungen der Skelettmuskulatur bei terminaler Niereninsuffizienz

Cited by 14 publications

References 8 publications

Evaluation of the Effect of Intravenous <i>L</i>-Carnitine Therapy on Function, Structure and Fatty Acid Metabolism of Skeletal Muscle in Patients Receiving Chronic Hemodialysis

Evaluation of the Effect of Intravenous <i>L</i>-Carnitine Therapy on Function, Structure and Fatty Acid Metabolism of Skeletal Muscle in Patients Receiving Chronic Hemodialysis

Impact of physical training on the ultrastructure of midthigh muscle in normal subjects and in patients treated with glucocorticoids.

1,25-Dihydroxyvitamin D₃and Muscle Strength in the Elderly: A Randomized Controlled Trial*

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Elektronenmikroskopische Untersuchungen der Skelettmuskulatur bei terminaler Niereninsuffizienz

Cited by 14 publications

References 8 publications

Evaluation of the Effect of Intravenous <i>L</i>-Carnitine Therapy on Function, Structure and Fatty Acid Metabolism of Skeletal Muscle in Patients Receiving Chronic Hemodialysis

Evaluation of the Effect of Intravenous <i>L</i>-Carnitine Therapy on Function, Structure and Fatty Acid Metabolism of Skeletal Muscle in Patients Receiving Chronic Hemodialysis

Impact of physical training on the ultrastructure of midthigh muscle in normal subjects and in patients treated with glucocorticoids.

1,25-Dihydroxyvitamin D3and Muscle Strength in the Elderly: A Randomized Controlled Trial*

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Product

Resources

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1,25-Dihydroxyvitamin D₃and Muscle Strength in the Elderly: A Randomized Controlled Trial*