Elektronenmikroskopische Untersuchungen der Milchdr�se des laktierenden Meerschweinchens mit Ber�cksichtigung des Saugaktes

Stockinger, L; Zarzicki, J.

doi:10.1007/bf00338930

Cited by 15 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to most secretory cells which produce membrane material to maintain a steady state, this cell accomplishes a considerable net synthesis of surface membrane material to replenish the apical plasma membrane expended in envelopment of milk fat globules (MFG) during secretion (9-11, 44, 58, 70, 77, 93, 142, 151, 156, 160, 161). The membrane which envelops MFG is biochemically similar, if not identical to plasma membrane from mammary gland (26,88,122,123,151,160). During the period of maximal lactation, it can be calculated that bovine mammary epithelial cells must replace plasma membrane material equivalent to their THE JOURNAL OF CELL BIOLOGY .…”

mentioning

confidence: 99%

Involvement of vesicle coat material in casein secretion and surface regeneration.

Franke¹,

Lüder²,

Kartenbeck³

et al. 1976

The Journal of Cell Biology

251

View full text Add to dashboard Cite

The ultrastructure of the apical zone of lactating rat mammary epithelial cells was studied, with emphasis on vesicle coat structures. Typical 40-60-nm ID "coated vesicles" were abundant, frequently associated with the internal filamentous plasma membrane coat or in direct continuity with secretory vesicles (SV) or plasma membrane proper. Bristle coats partially or totally covered membranes of secretory vesicles identified by their casein micelle content. This coat survived SV isolation. Exocytotic fusion of SV membranes and release of the casein micelles was observed. Frequently, regularly arranged bristle coat structures were identified in those regions of the plasma membrane that were involved in exocytotic processes. Both coated and uncoated surfaces of the casein-containing vesicles, as well as typical "coated vesicles," were frequently associated with microtubules and/or microfilaments. We suggest that coat materials of vesicles are related or identical to components of the internal coat of the surface membrane and that new plasma membrane and associated internal coat is produced concomitantly by fusion and integration of bristle coat moieties. Postexocytotic association of secreted casein micelles with the cell surface, mediated by finely filamentous extensions, provided a marker for the integrated vesicle membrane. An arrangement of SV with the inner surface of the plasma membrane is described which is characterized by regularly spaced, heavily stained membrane to membrane cross-bridges (pre-exocytotic attachment plaques). Such membrane-interconnecting elements may represent a form of coat structure important to recognition and interaction of membrane surfaces.

show abstract

mentioning

confidence: 99%

Involvement of vesicle coat material in casein secretion and surface regeneration.

Franke¹,

Lüder²,

Kartenbeck³

et al. 1976

The Journal of Cell Biology

251

View full text Add to dashboard Cite

show abstract

“…No morphological evidence is given for such a loss of microvilli and/or golgi vesicles into the alveolus. The occasional example of mammary cell breakdown seen in the literature (Feldman, 1961;Stein & Stein, 1967;Stockinger & Zarzicki, 1962) can be attributed to poor fixation or poor image quality. It is now generally accepted that the mammary secretory cell conserves its substance on release of secretion.…”

Section: Discussionmentioning

confidence: 99%

Milk fat globule membrane material in skim-milk

Wooding

1974

Journal of Dairy Research

View full text Add to dashboard Cite

SummaryIt has been claimed by Stewart, Puppione & Patton (1972) that milk is a valuable source of cell membrane in a ‘relatively pure’ state originating from shed mammary secretory cell microvilli and golgi vesicles. The morphological basis for this has been re-examined in this paper. It is shown that the vesicular and elongated membranous structures found in skim-milk are identical to structures present as part of the initial milk fat globule membrane (MFGM) of alveolar and expressed milk, and that both structures survive extraction with chloroform–methanol. It is therefore suggested that a major part of the skim-milk membrane is material shed from the freshly secreted milk fat globule and consists of a specialised derivative of the secretory cell plasmalemma, the initial MFGM.

show abstract

Morphology of Animal Secretory Gland Cells

Helander¹

1965

Sekretion Und Exkretion Funktionelle Und Morphologische Organisation Der Zelle

View full text Add to dashboard Cite

Elektronenmikroskopische Untersuchungen der Milchdr�se des laktierenden Meerschweinchens mit Ber�cksichtigung des Saugaktes

Cited by 15 publications

References 5 publications

Involvement of vesicle coat material in casein secretion and surface regeneration.

Involvement of vesicle coat material in casein secretion and surface regeneration.

Milk fat globule membrane material in skim-milk

Morphology of Animal Secretory Gland Cells

Contact Info

Product

Resources

About