Elegant One-Pot Synthesis of Quinolino[2′,3′:7,6]-cyclohept[1,2-b]indole Through Friedländer and Pfitzinger Annulation Reaction

Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV

“…Our synthetic route rests upon a Wittig reaction/divinylcyclopropane rearrangement cascade . To date, a few examples of racemic and only one example of an enantioselective synthesis of cyclohepta[ b ]indole systems exist . Our method tolerates a broad range of substituents at different positions of the seven-membered ring, making it a robust and general method to synthesize this structure motif (Figure ).…”

Synthesis of thieno- and benzocyclohepta[b]indoles: Gewald reaction and regioselective cycloaddition of acetylenic esters

“…As part of our ongoing program directed towards the development of new methodologies for the synthesis and biological evaluation of diverse heterocyclic compounds, [20][21][22][23] herein we disclose the synthesis of thienocyclohepta [b]indoles and benzocyclohepta [b]indoles from easily accessible starting materials.…”