Electrovestibulography: The "DC" potential used to separate Meniere's disease and Benign Paroxysmal Positional Vertigo

Garrett, Amber; Heibert, Daniel; Lithgow, Brian

doi:10.1109/iembs.2007.4352806

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…Previous studies suggested that EVestG responses are sensitive to alterations of neural activity in Parkinson's subjects (which might arise from disrupted brain DA systems) [12] as well as conditions relating directly to vestibular disturbance like Meniere's disease and Benign Paroxysmal Positional Vertigo [13].…”

Section: Introductionmentioning

confidence: 99%

EVestG™: A diagnostic measure for schizophrenia

Haghgooie

Lithgow²,

Gurvich

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Schizophrenia is a severe mental illness associated with multiple neuropathological, neurochemical and genetic abnormalities. The benefits of a validated, quantitative diagnosis tool are well established. Electrovestibulography, a new method similar to ECOG, can detect and record neural activity generated by the vestibular system. The normal EVestG response as well as dynamic measures averaged 'background-onAA' (onAA=acceleration phase of tilt) and 'background-onBB' (onBB=deceleration phase of tilt) of excitatory (ipsi-lateral tilt) vestibular responses are compared for a small group of schizophrenia patients (n=4) and age matched healthy controls (n=10). Our preliminary results show an apparent discrimination between control and schizophrenia groups. Schizophrenia patients appear not only to exhibit an overall decreased EVestG signal amplitude but a suppressed dynamic response calculated by the averaged EVestG 'background-onBB' measure. Increased sample size is required to validate these findings.

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Section: Introductionmentioning

confidence: 99%

EVestG™: A diagnostic measure for schizophrenia

Haghgooie

Lithgow²,

Gurvich

et al. 2008

2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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“…Among the EVestG tilts, the supine up/down tilt predominantly stimulates the utricular organ, and together with the sitting up/down tilt, which mainly stimulates the saccule, contains the lowest contribution of muscle artefacts, hemodynamic effects, and participant anxiety. Considering the closeness of the utricular maculae to the stapes and thus to the EVestG recording electrode, it is more likely that the EVestG response is mostly driven from the utricle [59]. Therefore, the selection of the supine up/down tilt for mutual separation of the three aforementioned groups can be considered physiologically and experimentally reasonable.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Diagnostic Value of Electrovestibulography (EVestG) in Alzheimer’s Patients with Mixed Pathology: A Pilot Study

Dastgheib,

Lithgow,

Moussavi

2023

Medicina

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Background and Objectives: Diagnosis of dementia subtypes caused by different brain pathophysiologies, particularly Alzheimer’s disease (AD) from AD mixed with levels of cerebrovascular disease (CVD) symptomology (AD-CVD), is challenging due to overlapping symptoms. In this pilot study, the potential of Electrovestibulography (EVestG) for identifying AD, AD-CVD, and healthy control populations was investigated. Materials and Methods: A novel hierarchical multiclass diagnostic algorithm based on the outcomes of its lower levels of binary classifications was developed using data of 16 patients with AD, 13 with AD-CVD, and 24 healthy age-matched controls, and then evaluated on a blind testing dataset made up of a new population of 12 patients diagnosed with AD, 9 with AD-CVD, and 8 healthy controls. Multivariate analysis was run to test the between population differences while controlling for sex and age covariates. Results: The accuracies of the multiclass diagnostic algorithm were found to be 85.7% and 79.6% for the training and blind testing datasets, respectively. While a statistically significant difference was found between the populations after accounting for sex and age, no significant effect was found for sex or age covariates. The best characteristic EVestG features were extracted from the upright sitting and supine up/down stimulus responses. Conclusions: Two EVestG movements (stimuli) and their most informative features that are best selective of the above-populations’ separations were identified, and a hierarchy diagnostic algorithm was developed for three-way classification. Given that the two stimuli predominantly stimulate the otholithic organs, physiological and experimental evidence supportive of the results are presented. Disruptions of inhibition associated with GABAergic activity might be responsible for the changes in the EVestG features.

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“…Elelctrovestibulography (EVestG). Although Garrett et al [90] concluded that the separation of the response into acceleration and deceleration might be beneficial in distinguishing between Benign Paroxysmal Positional Vertigo (BPPV) and Meniere's disease, the results suggested that the DC component warrants further analysis [91]. * A thesis in 2014 followed by a paper; both were captured during the screening and data analysis.…”

Section: Functional Biomarkers [Table 2 and 3]mentioning

confidence: 99%

Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders

et al. 2020

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The diagnostics of inner ear diseases are primarily functional, but there is a growing interest in inner ear biomarkers. The present scoping review aimed to elucidate gaps in the literature regarding the definition, classification system, and an overview of the potential uses of inner ear biomarkers. Relevant biomarkers were categorized, and their possible benefits were evaluated. The databases OVID Medline, EMBASE, EBSCO COINAHL, CA PLUS, WOS BIOSIS, WOS Core Collection, Proquest Dissertations, Theses Global, PROSPERO, Cochrane Library, and BASE were searched using the keywords “biomarker” and “inner ear”. Of the initially identified 1502 studies, 34 met the inclusion criteria. The identified biomarkers were classified into diagnostic, prognostic, therapeutic, and pathognomonic; many were detected only in the inner ear or temporal bone. The inner-ear-specific biomarkers detected in peripheral blood included otolin-1, prestin, and matrilin-1. Various serum antibodies correlated with inner ear diseases (e.g., anti-type II collagen, antinuclear antibodies, antibodies against cytomegalovirus). Further studies are advised to elucidate the clinical significance and diagnostic or prognostic usage of peripheral biomarkers for inner ear disorders, filling in the literature gaps with biomarkers pertinent to the otology clinical practice and integrating functional and molecular biomarkers. These may be the building blocks toward a well-structured guideline for diagnosing and managing some audio-vestibular disorders.

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Electrovestibulography: The "DC" potential used to separate Meniere's disease and Benign Paroxysmal Positional Vertigo

Cited by 8 publications

References 3 publications

EVestG™: A diagnostic measure for schizophrenia

EVestG™: A diagnostic measure for schizophrenia

Evaluating the Diagnostic Value of Electrovestibulography (EVestG) in Alzheimer’s Patients with Mixed Pathology: A Pilot Study

Biomarkers for Inner Ear Disorders: Scoping Review on the Role of Biomarkers in Hearing and Balance Disorders

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