Electrotherapy for the treatment of painful diabetic peripheral neuropathy – a review

Pieber, Karin; Herceg, Malvina; Paternostro-Sluga, Tatjana

doi:10.2340/16501977-0554

Cited by 64 publications

(45 citation statements)

References 39 publications

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“…SOD: superoxide dismutase; SD: standard deviation and calcium, the latter of which affects insulin secretion. In addition, magnetic field treatment can affect angiogenesis, neuronal protein synthesis, synaptic neurotransmitters, and axoplasmic transport, resulting in positive outcomes in patients with diabetic neuropathy (11,12).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, electromagnetic field therapy has shown promising effects in multiple sclerosis, peripheral facial paralysis, craniofacial pain, spasticity, and degenerative diseases of the retina (9), as well as having positive effects on blood glucose and calcium levels, the latter of which affects insulin secretion in diabetes (10). Low-frequency PEMF application had significant benefits in the treatment of resistant peripheral neuropathic pain, as well as reductions in subjective symptoms, and increases in nerve conduction functions and quality of life (11).…”

Section: Introductionmentioning

confidence: 99%

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Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Gozen¹,

Demirel²,

Akan³

et al. 2018

Eur J Ther

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Objective: The present study investigated the protective effects of a pulsed electromagnetic field (PEMF) in a rat model of diabetes by analyzing oxidative/nitrosative stress parameters. Methods: Rats were randomly divided into four groups of eight each: a control group, a sham PEMF group, a diabetes group, and a diabetes+PEMF group. Diabetes was induced in the sham PEMF, diabetes, and diabetes+PEMF groups by treatment with 50 mg/ kg streptozotocin (STZ). Rats in the sham PEMF group were treated identically, without running the instrument. Following the development of diabetes, rats in the diabetes+PEMF group were treated with PEMF for 60 min/day for 4 weeks. Results: Levels of oxidants, such as malondialdehyde (MDA), nitric oxide (NO), and myeloperoxidase (MPO), and antioxidants, such as superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), were measured in blood and liver tissue samples. MPO, MDA, and NO levels were significantly higher, and SOD levels significantly lower, in the sham PEMF and diabetes groups than in the control group (p<0.05 each), whereas the levels of all these four (i.e.: MPO, MDA, NO, and SOD) in the diabetes+PEMF group were close to those in the control group. GSH levels were significantly lower in the sham PEMF, diabetes, and diabetes+PEMF groups than in the control group (p<0.05 each), whereas CAT levels were similar in all the four groups. Conclusion: Results indicate that PEMF affects MDA, NO, MPO, SOD, and GSH levels and regulates diabetes-associated damage by reducing oxidative stress and increasing the levels of antioxidants. PEMF may be a non-invasive treatment option for diabetes and associated complications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Gozen¹,

Demirel²,

Akan³

et al. 2018

Eur J Ther

View full text Add to dashboard Cite

show abstract

“…Although the physiological mechanisms responsible for PEMF analgesia remain uncertain, some authors have suggested that PEMF could influence pain via its effect on nitric oxide (NO), calmodulin (CaM) and/or opioid pathways (Abramson 2008;Diniz et al 2002;Fitzsimmons et al 2008;Pilla 2013;Staniland et al 2010). To date however, results of studies looking into the effects of PEMF on pain have been inconsistent (Pieber et al 2010;Ryang We et al 2013;Teasell et al 2010;Vavken et al 2009). Given the effect of PEMF on tissue repair pathways (Callaghan et al 2008;Fitzsimmons et al 2008;Pilla et al 2011), it also remains difficult to determine if the analgesic effect observed in patients who received PEMF is attributable to a direct effect of PEMF on pain or to an indirect effect of PEMF on inflammation and healing.…”

Section: Introductionmentioning

confidence: 99%

Effect of pulsed electromagnetic field therapy on experimental pain: A double-blind, randomized study in healthy young adults

Beaulieu

Beland

Pinard

et al. 2016

Electromagnetic Biology and Medicine

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Past studies have suggested that pulsed electromagnetic field (PEMF) therapy can decrease pain. To date, however, it remains difficult to determine if the analgesic effect observed in patients are attributable to a direct effect of PEMF on pain or to an indirect effect of PEMF on inflammation and healing. In the present study, we used an experimental pain paradigm to evaluate the direct effect of PEMF on pain intensity, pain unpleasantness and temporal summation of pain. Twenty-four healthy subjects (mean age 22 ± 2 years; 9 males) participated in the experiment. Both real and sham PEMF were administered to every participant using a randomized, double-blind, cross-over design.For each visit, PEMF was applied for 10 minutes on the right forearm using a portable device. Experimental pain was evoked before (baseline) and after PEMF with a 9 cm 2 Pelletier type thermode, applied on the right forearm (120 sec stimulation; temperature individually adjusted to produce moderate baseline pain). Pain intensity and unpleasantness were evaluated using a 0-100 numerical pain rating scale.

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“…However, results of the studies describing the effects of these modalities on peripheral neuropathy remain controversial, and randomized-controlled studies with larger sample sizes and long followup periods are needed in order to better elucidate the efficacy of these modalities. And, although electrotherapy modalities may help decrease pain [7], they do not restore blood flow, which may limit their ability to improve sensation. Therefore, there is a need for a modality that works to restore blood flow.…”

Section: Introductionmentioning

confidence: 99%

Monochromatic Infrared Photo Energy in Diabetic Peripheral Neuropathy

Ammar

2012

ISRN Rehabilitation

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Diabetes is a very common cause of peripheral neuropathy, and there is no optimal intervention universally accepted by clinicians. Monochromatic infrared photo energy is a relatively new modality used in the United States for reducing pain and increasing circulation. This study investigated the effects of monochromatic infrared photo energy on reducing pain, improving sensation, and increasing balance in patients with diabetic peripheral neuropathy. Thirty-five patients with diabetic peripheral neuropathy completed the program and were randomly assigned into two groups. Group 1 (experimental, n = 18) received monochromatic infrared photo energy, therapeutic exercises, and balance training. Group 2 (control, n = 17) received therapeutic exercises and balance training. Both groups received three treatment sessions per week for 4 weeks. Outcome included pain intensity measured on a visual analogue scale, sensation measured with the Semmes-Weinstein monofilament 5.07, and balance measured with the Berg score, before and after the 12 therapy sessions (1 month after the start of the intervention). Analysis of covariance tests revealed statistically significant improvements, specifically, P = .01, .014, and .0001, for pain, sensation, and balance, respectively, in the experimental group. Within the limitations of this study, monochromatic infrared photo energy may play a role in treating diabetic peripheral neuropathy by reducing pain, improving sensation, and increasing balance.

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Electrotherapy for the treatment of painful diabetic peripheral neuropathy – a review

Abstract: Further randomized, double-blind, placebo-controlled studies comprising larger sample sizes, a longer duration of treatment, and longer follow-up assessments are required.

Cited by 64 publications

References 39 publications

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Effect of pulsed electromagnetic field therapy on experimental pain: A double-blind, randomized study in healthy young adults

Monochromatic Infrared Photo Energy in Diabetic Peripheral Neuropathy

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