Electrotherapy and hyperbaric oxygen: Promising treatments for postradiation complications

King, Gordon E.; Scheetz, Jan; Jacob, Rhonda F.; Martin, Jack W.

doi:10.1016/0022-3913(89)90344-2

Cited by 44 publications

(21 citation statements)

References 8 publications

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“…Microcurrent relieves myocontracture and can enhance conventional rehabilitation programs for children with cerebral palsy 24. Studies from the 1980s suggest that microcurrent therapy is effective at relieving the side effects of radiation therapy 25. The investigators have found that direct electrical therapy was effective in healing gum abscess and accelerated wound healing 20.…”

Section: Discussionmentioning

confidence: 99%

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

Lee¹,

Al-Waili²,

Stubbs³

et al. 2010

Int. J. Med. Sci.

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Oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus and cardiovascular diseases including hypertension. The low levels of antioxidants accompanied by raised levels of markers of free radical damage play a major role in delaying wound healing. Ultra-low microcurrent presumably has an antioxidant effect, and it was shown to accelerate wound healing. The purpose of the study is to investigate the efficacy of ultra-low microcurrent delivered by the Electro Pressure Regeneration Therapy (EPRT) device (EPRT Technologies-USA, Simi Valley, CA) in the management of diabetes, hypertension and chronic wounds. The EPRT device is an electrical device that sends a pulsating stream of electrons in a relatively low concentration throughout the body. The device is noninvasive and delivers electrical currents that mimic the endogenous electric energy of the human body. It is a rechargeable battery-operated device that delivers a direct current (maximum of 3 milliAmperes) of one polarity for 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes. The resulting cycle time is approximately 23min or 0.000732 Hz and delivers a square wave bipolar current with a voltage ranging from 5V up to a maximum of 40 V. The device produces a current range of 3 mA down to 100 nA. Twelve patients with long standing diabetes, hypertension and unhealed wounds were treated with EPRT. The patients were treated approximately for 3.5 h/day/5 days a week. Assessment of ulcer was based on scale used by National Pressure Ulcer Advisory Panel Consensus Development Conference. Patients were followed-up with daily measurement of blood pressure and blood glucose level, and their requirement for medications was recorded. Treatment continued from 2-4 months according to their response. Results showed that diabetes mellitus and hypertension were well controlled after using this device, and their wounds were markedly healed (30-100%). The patients either reduced their medication or completely stopped after the course of treatment. No side effects were reported. The mechanism of action was discussed.

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Section: Discussionmentioning

confidence: 99%

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

Lee¹,

Al-Waili²,

Stubbs³

et al. 2010

Int. J. Med. Sci.

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“…Conservative measures with HBOT and pentoxifylline did not show any convincing improvement of trismus [168,169]. The same was observed for injections of botulinum toxin into the mastication muscles, though they can effectively reduce local pain produced by muscle spasms associated with trismus [170].…”

Section: Trismusmentioning

confidence: 97%

Treatment of late sequelae after radiotherapy for head and neck cancer

Strojan

Hutcheson

Eisbruch

et al. 2017

Cancer Treatment Reviews

243

171

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Radiotherapy (RT) is used to treat approximately 80% of patients with cancer of the head and neck. Despite enormous advances in RT planning and delivery, a significant number of patients will experience radiation-associated toxicities, especially those treated with concurrent systemic agents. Many effective management options are available for acute RT-associated toxicities, but treatment options are much more limited and of variable benefit among patients who develop late sequelae after RT. The adverse impact of developing late tissue damage in irradiated patients may range from bothersome symptoms that negatively affect their quality of life to severe life-threatening complications. In the region of the head and neck, among the most problematic late effects are impaired function of the salivary glands and swallowing apparatus. Other tissues and structures in the region may be at risk, depending mainly on the location of the irradiated tumor relative to the mandible and hearing apparatus. Here, we review the available evidence on the use of different therapeutic strategies to alleviate common late sequelae of RT in head and neck cancer patients, with a focus on the critical assessment of the treatment options for xerostomia, dysphagia, mandibular osteoradionecrosis, trismus, and hearing loss.

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“…Regardless of the relative commonness of this condition and its harmful effects on daily functioning and quality of life, there are only few studies concerning the treatment of limitation of mouth opening and no standard care exists [4]. Although physical therapy, hyperbaric oxygen [11], pentoxifylline [12], botulinum toxin injection [13], and surgical coronoidectomy [3] have been used for treating the condition. However, mouth opening appliances provide a conservative approach to therapy in addition to being easy to use and having better efficacy than physiotherapy and surgery [14,15].…”

Section: Discussionmentioning

confidence: 99%

Developing a New Appliance to Dissipate Mechanical Load on Teeth and Improve Limitation of Vertical Mouth Opening

Satomi¹,

Tanaka²,

Kobayashi³

et al. 2013

JOMR

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Objectives: The principle of leverage to superpose the convex surfaces of two shells was applied to develop a device for treating limitation of mouth opening and called it the "shell-shaped mouth opener" and analyzed pressure on the teeth with the TheraBite ® appliance and the shell-shaped mouth opening appliance. Material and Methods: To compare the TheraBite ® appliance and the shell-shaped mouth opening appliance, pressure on the teeth in the dentition model with both devices was analyzed using the Inastomer ® flexible conductive sensor. Results: The load was better dispersed to each tooth in the shell-shaped mouth opening appliance in the all quadrants compared to the TheraBite ® appliance. Conclusions: The present study revealed that the shell-shaped mouth opening appliance which was originally invented in our lab, dissipated the mechanical load on teeth more evenly than the TheraBite ® appliance.

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Electrotherapy and hyperbaric oxygen: Promising treatments for postradiation complications

Cited by 44 publications

References 8 publications

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action

Treatment of late sequelae after radiotherapy for head and neck cancer

Developing a New Appliance to Dissipate Mechanical Load on Teeth and Improve Limitation of Vertical Mouth Opening

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