Electrostimulated bone marrow human mesenchymal stem cells produce follistatin

Genovese, Jorge; Spadaccio, Cristiano; Rivello, Hernán García; Toyoda, Yoshiya; Patel, Amit N.

doi:10.1080/14653240902960445

Cited by 22 publications

(23 citation statements)

References 46 publications

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“…FSTL1 combination with other established drugs would treat bone metastasis more effectively. It has been shown that bone marrow-derived MSCs express FSTL1 (22). Also, some ALCAM þ cells expressed FSTL1…”

Section: Discussionmentioning

confidence: 99%

Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction

et al. 2013

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Bone metastasis greatly deteriorates the quality of life in patients with cancer. Although mechanisms have been widely investigated, the relationship between cancer bone metastasis and antitumor immunity in the host has been much less studied. Here, we report a novel mechanism of bone metastasis mediated by FSTL1, a follistatinlike glycoprotein secreted by Snail þ tumor cells, which metastasize frequently to bone. We found that FSTL1 plays a dual role in bone metastasis-in one way by mediating tumor cell invasion and bone tropism but also in a second way by expanding a population of pluripotent mesenchymal stem-like CD45 À ALCAM þ cells derived from bone marrow. CD45 À ALCAM þ cells induced bone metastasis de novo, but they also generated CD8 low T cells with weak CTL activity in the periphery, which also promoted bone metastasis in an indirect manner. RNA interferencemediated attenuation of FSTL1 in tumor cells prevented bone metastasis along with the parallel increase in ALCAM þ cells and CD8 low T cells. These effects were accompanied by heightened antitumor immune responses in vitro and in vivo. In clinical specimens of advanced breast cancer, ALCAM þ cells increased with FSTL1 positivity in tumor tissues, but not in adjacent normal tissues, consistent with a causal connection between these molecules. Our findings define FSTL1 as an attractive candidate therapeutic target to prevent or treat bone metastasis, which remains a major challenge in patients with cancer. Cancer Res; 73(20); 6185-93. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 99%

Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction

et al. 2013

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“…Two major mechanisms are proposed to be underlying the therapeutic effect of CD34 + AMSPC transplantation on the hepatic fibrosis: replacement of damaged cells and local delivery of bioactive molecules [55]. Replacement of cells is the goal of cell therapy for regenerative medicine, and the release of biological signals, as mediators or receptors, is the basis for many cellular processes, including immunomodulation induced by mesenchymal stem cells.…”

Section: Discussionmentioning

confidence: 99%

Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34+ Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury

Lee

Hsiao

et al. 2016

Stem Cells Translational Medicine

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“…In addition to the mechanical stimulation of polymeric materials, electrical stimulation is another promising approach to regulate the fate of hMSC (Hess et al , 2012;Genovese et al , 2009). Employment of both biophysical (electrical fi eld stimulation) and biochemical stimulation (collagen-based substrates) were demonstrated in order to compare their effects on the regulation of hMSC (Hess et al , 2012).…”

Section: Regulated Differentiation For Human Mesenchymal Stem Cells (mentioning

confidence: 99%

Mediated differentiation of stem cells by engineered semiconducting silicon nanowires

Yen

Lin

2014

Semiconducting Silicon Nanowires for Biomedical Applications

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Electrostimulated bone marrow human mesenchymal stem cells produce follistatin

Cited by 22 publications

References 46 publications

Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction

Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction

Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34+ Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury

Mediated differentiation of stem cells by engineered semiconducting silicon nanowires

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