Electrostatically crosslinked cellulose nanocrystal and polyelectrolyte complex sponges with pH responsiveness

Boas, Mor; Martin, Patrick; Vasilyev, Gleb; Lee, Jong-Gun; Vilensky, Rita; Xu, Chengzhang; Greiner, Andreas; Zussman, Eyal

doi:10.1016/j.carbpol.2021.118131

Cited by 9 publications

(5 citation statements)

References 59 publications

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“…In parallel, Kumar et al designed the aligned chitosan–gelatin (CG) cryogel filler, using a unidirectional-freezing method, for peripheral nerve regeneration. Overall, cryogels demonstrate a set of unique properties, including excellent water swelling, large water content, and highly compressible mechanical properties due to their macroporous structure, which propels their application in tissue engineering. − …”

Section: Introductionmentioning

confidence: 99%

Fabrication of Anisotropic Silk Fibroin-Cellulose Nanocrystals Cryogels with Tunable Mechanical Properties, Rapid Swelling, and Structural Recoverability via a Directional-Freezing Strategy

Dai

Meng

et al. 2021

ACS Sustainable Chem. Eng.

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A hierarchically anisotropic structure is widely found in natural materials, such as tendons and wood for performing specific functions. However, fabrication of anisotropic materials with interconnected macropores achieving anisotropic structural and mechanical characteristics simultaneously is still a major challenge. Silk fibroin (SF) has attracted great interest as a multifunctional biomaterial, owing to its remarkable mechanical properties, excellent biodegradability, and biocompatibility. In this work, we present a directional-freezing strategy for preparing anisotropic SF-cellulose nanocrystal (CNC) cryogels based on multiple hydrogen bonds between SF, poly(ethylene glycol) (PEG), and cellulose nanocrystals (CNCs) with an orientated microstructure and freezing-direction-dependent mechanical performance, which are reminiscent of natural tissues. The incorporated CNCs acting as connected bridges in the hierarchically porous network can not only endow the SF-CNC cryogels with improved structural stability but also increase the β-sheet amount to improve the cross-link density of an SF network, which collaboratively improved the mechanical properties with Young's modulus of 709 and 160 kPa along the direction parallel and perpendicular to the freezing direction, respectively. Intriguingly, the SF-CNC cryogels display rapid swelling behavior and structural recoverability ascribed to the macroporous structure and abundant hydrophilic groups. Additionally, the resultant SF-CNC cryogels are degradable in a protease XIV solution and the degradation behavior is ascribed to the surface erosion of the SF-CNC cryogels and breakdown of the β-sheet crystalline structure of silk fibroin. Overall, this study suggests a facile and ecofriendly approach via directional freezing to fabricate anisotropic SF-CNC cryogels, which opens up a new prospect for soft-tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

Fabrication of Anisotropic Silk Fibroin-Cellulose Nanocrystals Cryogels with Tunable Mechanical Properties, Rapid Swelling, and Structural Recoverability via a Directional-Freezing Strategy

Dai

Meng

et al. 2021

ACS Sustainable Chem. Eng.

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“…When cCNCs are mixed with anionic HA, electrostatic complexation occurs. Since HA has a high molecular weight, one could expect HA to bridge cCNC rod-like particles and form a stronger structure than that of cCNCs only. , However, the mixing produced different results. For the HA–cCNC with 2% cCNCs, no yield behavior was registered, and only a moderate ∼4-fold viscosity increase compared to the viscosity of pure HA was observed in the region of low stresses (Figure a).…”

Section: Resultsmentioning

confidence: 98%

Injectable Hydrogels Based on Inter-Polyelectrolyte Interactions between Hyaluronic Acid, Gelatin, and Cationic Cellulose Nanocrystals

et al. 2022

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The present work dealt with the development of physically cross-linked injectable hydrogels with potential applications in tissue engineering. The hydrogels were composed of a ternary mixture of a polyanion and a polyampholyte, hyaluronic acid (HA) and gelatin, respectively, bridged by cationic cellulose nanocrystals (cCNCs). A 3D network is formed by employing attractive electrostatic interactions and hydrogen bonding between these components under physiological conditions. The hydrogels demonstrated low viscosity at high stresses, enabling easy injection, structural stability at low stresses (<15 Pa), and nearly complete structure recovery within several minutes. Increasing the cCNC content (>3%) reduced hydrogel swelling and decelerated the degradation in phosphate-buffered saline as compared to that in pure HA and HA−gelatin samples. Biological evaluation of the hydrogel elutions showed excellent cell viability. The proliferation of fibroblasts exposed to elutions of hydrogels with 5% cCNCs reached ∼200% compared to that in the positive control after 11 days. Considering these results, the prepared hydrogels hold great potential in biomedical applications, such as injectable dermal fillers, 3D bioprintable inks, or 3D scaffolds to support and promote soft tissue regeneration.

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“…33,34 Emerging applications in biomedical and food engineering, personal care, and water purification, as well as the striving for ''green processing'' -that is, abstaining from the use of toxic organic solvents -raise interest in PEs. [35][36][37] Examples of naturally-occurring PEs include proteins, DNA or RNA, or certain polysaccharides such as xanthan, alginate, chitosan, This journal is © The Royal Society of Chemistry 2024 hyaluronic acid, etc. 38 It is well-known that the behaviour of PEs in solution is significantly affected by the charges on the PE backbone and interactions with the corresponding oppositely charged counterions and cannot be modeled by superimposing the behaviours of uncharged polymers and electrolytes.…”

Section: Introductionmentioning

confidence: 99%

Charge transport in electrospinning of polyelectrolyte solutions

Martin,

Zussman

2024

Soft Matter

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Electrostatically crosslinked cellulose nanocrystal and polyelectrolyte complex sponges with pH responsiveness

Cited by 9 publications

References 59 publications

Fabrication of Anisotropic Silk Fibroin-Cellulose Nanocrystals Cryogels with Tunable Mechanical Properties, Rapid Swelling, and Structural Recoverability via a Directional-Freezing Strategy

Fabrication of Anisotropic Silk Fibroin-Cellulose Nanocrystals Cryogels with Tunable Mechanical Properties, Rapid Swelling, and Structural Recoverability via a Directional-Freezing Strategy

Injectable Hydrogels Based on Inter-Polyelectrolyte Interactions between Hyaluronic Acid, Gelatin, and Cationic Cellulose Nanocrystals

Charge transport in electrospinning of polyelectrolyte solutions

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