Electrospun zwitterionic nanofibers with in situ decelerated epithelialization property for non-adherent and easy removable wound dressing application

Unnithan, Afeesh Rajan; Nejad, Amin Ghavami; Sasikala, Arathyram Ramachandra Kurup; Thomas, Reju George; Jeong, Yong Yeon; Murugesan, Priya; Nasseri, Saeed; Wu, Dongmei; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.cej.2015.11.086

Cited by 78 publications

(37 citation statements)

References 41 publications

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“…64,100,101 An alternative strategy towards creating hemocompatible surfaces is to change the polymer’s surface topography, thereby mediating subsequent biological responses. Creating a submicron-textured surface can dramatically reduce the accessible contact area for platelets or bacteria to interact with the surface, thereby minimizing the opportunities for bacteria and platelet adsorption.…”

Section: Creating Dual-functionality Hemocompatible Surfacesmentioning

confidence: 99%

“…To improve the NO payload and stability, achieve targeted NO delivery through multi-functionalization and elongate NO releasing lifetime, many different scaffolds have been used as NO-releasing or NO-generating vehicles. These include micelles, 138,190,191 microbubbles, 192 proteins, 193–197 liposomes, 126,198 inorganic nanoparticles (such as silica, 70,199–203 gold, 204,205 microparticles, 198,206 zeolites, 207,208 ), metal-organic frameworks (MOFs), 209–212 dendrimers, 71,213,214 xerogels, 215–217 electrospun fibers, 88,100,218 natural polymers (chitosan, 85–87,219–221 gelatin, 222 etc. ), and other organic polymers (polymethacrylate, 223 polyester, 224,225 polydimethylsiloxane (PDMS), 226 polysaccharides, 227,228 hydrogel, 178,179,229,230 PVA, 49,231,232 polyurethanes, 161,162,233,234 and PVC 154 ).…”

Section: Polymer-based Strategies For No Deliverymentioning

confidence: 99%

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Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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Biomedical devices are essential for patient diagnosis and treatment; however, when blood comes in contact with foreign surfaces or homeostasis is disrupted, complications including thrombus formation and bacterial infections can interrupt device functionality, causing false readings and/or shorten device lifetime. Here, we review some of the current approaches for developing antithrombotic and antibacterial materials for biomedical applications. Special emphasis is given to materials that release or generate low levels of nitric oxide (NO). Nitric oxide is an endogenous gas molecule that can inhibit platelet activation as well as bacterial proliferation and adhesion. Various NO delivery vehicles have been developed to improve NO’s therapeutic potential. In this review, we provide a summary of the NO releasing and NO generating polymeric materials developed to date, with a focus on the chemistry of different NO donors, the polymer preparation processes, and in vitro and in vivo applications of the two most promising types of NO donors studied thus far, N-diazeniumdiolates (NONOates) and S-nitrosothiols (RSNOs).

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Section: Creating Dual-functionality Hemocompatible Surfacesmentioning

confidence: 99%

Section: Polymer-based Strategies For No Deliverymentioning

confidence: 99%

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

et al. 2016

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“…Moreover, wound healing is a dynamic process, and the performance of a dressing material is influenced by the progression of the healing phase. In this context, a warm and moist environment promotes faster wound healing (4,7,8). Moist dressing not only increases the rate of epithelialisation but also…”

Section: Introductionmentioning

confidence: 99%

Biodegradable hydrogel‐based biomaterials with high absorbent properties for non‐adherent wound dressing

Kumar

Wang

Nune

et al. 2017

International Wound Journal

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Dressing materials involve conventional gauzes and modern materials such as hydrogels and foam-based biomaterials. Although the choice of dressing material depends on the type of wound, a dressing material is expected to be non-cytotoxic. Additionally, moist dressing is considered appropriate to accelerate epithelialisation, while dry dressing may cause tissue damage during removal. An ideal dressing material is expected to provide a moist environment and degrade and release the drug for faster wound healing. Thus, we have designed a hydrogel-based biodegradable dressing material to provide the moist environment with no cytotoxic effect in vitro. The design of the hydrogel involved alginate-collagen reinforced with whisker cellulose derived from cotton. The hydrogel was prepared via amide linkage in the presence of 1-ethyl-(dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysulfosuccinimide (NHS), followed by divalent cationic cross-linking of alginate and hydrogen bonding with cellulose. The high water retention capability of the hydrogel enables a moist environment to be maintained in the wounded area. The constituents of the hydrogel provided a microenvironment that was suitable for cell proliferation in the vicinity of the hydrogel but inhibited cell attachment on it. The MTT assay results indicated a higher fibroblast proliferation and viability in the presence of the hydrogel.

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“…The wound-care management is considered to be a serious health-care issue since the skin is the main organ of the body and plays vital role in multiple functions [34]. Depending on the healing time, the wounds are categorized as acute and chronic in which the chronic wounds are highly exposed to the risk of bacterial infection.…”

Section: Wound Dressingmentioning

confidence: 99%

Electrospun Materials for Tissue Engineering and Biomedical Applications

2017

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Electrospun zwitterionic nanofibers with in situ decelerated epithelialization property for non-adherent and easy removable wound dressing application

Cited by 78 publications

References 41 publications

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO)

Biodegradable hydrogel‐based biomaterials with high absorbent properties for non‐adherent wound dressing

Electrospun Materials for Tissue Engineering and Biomedical Applications

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