Electrospun Wound Dressing As a Promising Tool for the Therapeutic Delivery of Ascorbic Acid and Caffeine

Avizheh, Laya; Peirouvi, Tahmineh; Diba, Kambiz; Azarbayjani, Anahita Fathi

doi:10.4155/tde-2019-0059

Cited by 18 publications

(11 citation statements)

References 26 publications

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“…Histological analysis of collected wound tissue treated by acidic buffers revealed high level of collagen deposition at the wounded site. Collagen is known to be a key component in the formation of an extracellular matrix contributing to mechanical strength and elasticity of repaired tissues [ 53 , 54 ]. As collected tissues were shown to be fully re-epithelialize by day 7, higher levels of collagen deposition at a later stage of the wound healing process is also evidence of increased wound closure and re-modelling activity when treated with acidic buffers, as previously described.…”

Section: Discussionmentioning

confidence: 99%

Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment

Sim

Strudwick

Song

et al. 2022

IJMS

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There has been little understanding of acidification functionality in wound healing, highlighting the need to study the efficacy of wound acidification on wound closure and cellular activity in non-infected wounds. This study is focused on establishing the healing potential of wound acidification in non-infected wounds. Acidic buffers, constituting either phosphoric or citric acid, were employed to modify the physiological pH of non-infected full-thickness excisional murine wounds. Acidification of the wound by acidic buffers was found to be an effective strategy to improve wound healing. A significant improvement in wound healing parameters was observed as early as 2 days post-treatment with acidic buffers compared to controls, with faster rate of epithelialization, wound closure and higher levels of collagen at day 7. pH is shown to play a role in mediating the rate of wound healing, with acidic buffers formulated at pH 4 observed to stimulate faster recovery of wounded tissues than pH 6 buffers. Our study shows the importance of maintaining an acidic wound microenvironment at pH 4, which could be a potential therapeutic strategy for wound management.

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Section: Discussionmentioning

confidence: 99%

Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment

Sim

Strudwick

Song

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…This peak was intensified, as compared to drug-free scaffolds, due to the overlap with gelatin amide I bond. 3220.54 cm-1 bandwidth, due to -OH stretching bands, could be regarded as the reason for loading Vitamin C in the scaffold structure [52], [53]. In the FTIR diagram of all samples, the peaks of the materials in the scaffold were confirmed.…”

Section: Discussionmentioning

confidence: 79%

A promising antibacterial wound dressing made of electrospun Poly (Glycerol Sebacate) / Gelatin with local delivery of Ascorbic Acid and Pantothenic Acid

Kermani

Kharazi

2022

Preprint

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Wounds can be caused by cuts, burns, surgeries, illnesses or accidents. The wound healing process can be disrupted by improper treatment conditions. The use of wound dressings has been the best treatment for chronic wounds. In this study, first, Poly (Glycerol Sebacate) was synthesized; then Poly (Glycerol Sebacate)-gelatin copolymer wound dressing containing vitamin B5 was made by electrospinning method. The membrane was crosslinked in the EDC/NHS solution and then loaded with vitamin C. The results indicated passage of water vapor, hydrophilicity and water absorption in samples with vitamins were ideal for wound healing process and absorption exude at wound site. On the other site, the degradation process showed the wound dressing stable during 14 days. As the following, the vitamin C and vitamin B5 release demonstrated burst release during 1 and 6 hours, respectively. Antibacterial results showed the presence of vitamin B5 in PGS/gelatin wound dressing can prevent the gram-negative and gram-positive bacteria growth. According cell viability assay, Vitamin C enhanced cell adhesion and cell proliferation. Finally, the PGS/gelatin with vitamin C/ vitamin B5 wound dressing with ideal biological properties recommend as a suitable wound healing product.

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“…The antimicrobial effects of caffeine are well-documented. On the fungal level, a wound dressing that delivers caffeine alone or in combination with ascorbic acid showed a clear antifungal activity against C. albicans using the disc diffusion method [ 32 ]. In one study, caffeine enhanced the antifungal activity of chloroquine through induction of the cell wall perturbation [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

The Antifungal and Antibiofilm Activities of Caffeine against Candida albicans on Polymethyl Methacrylate Denture Base Material

et al. 2022

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Background: In this study, the effect of pure caffeine was established against Candida albicans (C. albicans) using different microbiological techniques. Methods: Broth microdilution and colony forming units (CFUs) assays were used to detect the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The Live/Dead fluorescent dyes were implemented to determine the yeast viability. Polymethyl methacrylate acrylic resin (PMMA) discs were prepared to evaluate caffeine’s effects against adherent C. albicans using microplate reader, CFUs, and scanning electron microscope (SEM). Results: caffeine’s MIC was detected around 30 mg/mL, while the MFC was considered at 60 mg/mL. In an agar-well diffusion test, the inhibition zones were wider in caffeine groups. The Live/Dead viability test verified caffeine’s antifungal effects. The optical density of the adherent C. albicans on PMMA discs were lower at 620 nm or 410 nm in caffeine groups. CFU count was also reduced by caffeine treatments. SEM revealed the lower adherent C. albicans count in caffeine groups. The effect of caffeine was dose-dependent at which the 60 mg/mL dose demonstrated the most prominent effect. Conclusion: The study reinforced caffeine’s antifungal and antibiofilm properties and suggested it as an additive, or even an alternative, disinfectant solution for fungal biofilms on denture surfaces.

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Electrospun Wound Dressing As a Promising Tool for the Therapeutic Delivery of Ascorbic Acid and Caffeine

Cited by 18 publications

References 26 publications

Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment

Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment

A promising antibacterial wound dressing made of electrospun Poly (Glycerol Sebacate) / Gelatin with local delivery of Ascorbic Acid and Pantothenic Acid

The Antifungal and Antibiofilm Activities of Caffeine against Candida albicans on Polymethyl Methacrylate Denture Base Material

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