Electrospun three-dimensional aligned nanofibrous scaffolds for tissue engineering

Jin, Guorui; He, Rongyan; Sha, Baoyong; Li, Wenfang; Qing, Huaibin; Teng, Rui; Xu, Feng

doi:10.1016/j.msec.2018.06.065

Cited by 97 publications

(64 citation statements)

References 140 publications

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“…Nevertheless, a big challenge was mentioned for them that related to their static status. For example, they cannot remodel their stiffness, surface chemistry and roughness in an in situ and dynamic situation, so cannot mimic the function of main tissue (Jin et al 2018). Rather et al reviewed the dual functional strategies to spread osteogenesis coupled angiogenesis through different scaffolds.…”

Section: Scaffolds Combined With Active Biomoleculesmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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Nowadays, bone diseases and defects as a result of trauma, cancers, infections and degenerative and inflammatory conditions are increasing. Consequently, bone repair and replacement have been developed with improvement of orthopedic technologies and biomaterials of superior properties. This review paper is intended to sum up and discuss the most relevant studies performed in the field of bone biology and bone regeneration approaches. Therefore, the bone tissue regeneration was investigated by synthetic substitutes, scaffolds incorporating active molecules, nanomedicine, cell-based products, biomimetic fibrous and nonfibrous substitutes, biomaterial-based three-dimensional (3D) cell-printing substitutes, bioactive porous polymer/inorganic composites, magnetic field and nano-scaffolds with stem cells and bone-biomaterials interface studies.

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Section: Scaffolds Combined With Active Biomoleculesmentioning

confidence: 99%

Bone tissue regeneration: biology, strategies and interface studies

2019

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“…The architectural design of the TE scaffolds is very important for their success. The growing preference towards 3D porous structures over the traditional two dimensional (2D) materials has allowed exceptional features and large surface area-to-volume ratio scaffolds to be engineered, with light weight, flexibility, high porosity, spatial alignment or random deposition (depending on its purpose), and an interconnected network [88,98]. Light, insoluble and stable PVA scaffolds can be produced with a 3D rendering and modified to promote the adhesion of healthy human mesenchymal stem cells (hMSCs) within the 3D micro-niches of the construct.…”

Section: Tissue Engineering Applications Of Pva-based Nanofibrous Scamentioning

confidence: 99%

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

2019

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Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed.

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“…Several researchers have investigated different methods to fabricate biomimetic skin scaffold. [ 16,17,19,20 ] The first commonly used approach is the electrospinning technique that has been intensively applied due to the advantages of reproducibility, simplicity, and diversity in producing fibers with micro‐ or nanoscale diameters and different topographical features. [ 21,22 ] The fibers' membrane produced by electrospinning can provide large surface areas for cells to attach and proliferate, which could also enhance the penetration of nutrients and oxygen.…”

Section: Introductionmentioning

confidence: 99%

“…Due to the distinct differences between 2D culture in vitro and the native cellular microenvironment in aspects of physical and chemical properties, 2D scaffolds cannot maintain the phenotypes of cells derived from complex multi‐cellular tissues. [ 25,26 ] Therefore, the electrospinning process was mainly applied in fabricating thinner epidermal substitute or external wound dressing.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Liu

Zhang

et al. 2020

Macro Materials & Eng

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Skin injuries are an urgent health issue, which raises a great concern in the clinic. Although numerous strategies have been proposed to fabricate skin substitutes for treatment of wounds over the past several decades, fabricating an ideal skin substitute to replace the damaged one can still be a problem. In this study, a novel biomimetic 3D composite skin scaffold is fabricated by combining electrohydrodynamic (EHD) jetting, electrospinning, and coating techniques. Here, the first polycaprolactone (PCL) porous structure is produced by the EHD jetting. Next, the second polylactic acid (PLA) membrane consisted of nanoscale fibers is prepared on the PCL porous structure via the electrospinning. The PCL porous structure and PLA fibers membrane can mimic the dermis and epidermis layer, respectively. Furthermore, gelatin is used as coating solution to enhance the biocompatibility of the scaffold. The structure and morphology of the fabricated scaffolds are analyzed, and the mechanical properties are investigated as well. Moreover, the in vitro and in vivo experiments demonstrate the biocompatibility of the materials and the fabrication process. In conclusion, these results demonstrate that the composite scaffold is effective and holds great potential for skin regeneration in the clinic.

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Electrospun three-dimensional aligned nanofibrous scaffolds for tissue engineering

Cited by 97 publications

References 140 publications

Bone tissue regeneration: biology, strategies and interface studies

Bone tissue regeneration: biology, strategies and interface studies

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

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