Electrospun structural nanohybrids combining three composites for fast helicide delivery

Liu, Huan; Wang, Haibin; Lü, Xin; Murugadoss, Vignesh; Huang, Mina; Yang, Haisong; Wan, Fuxian; Yu, Deng‐Guang; Guo, Zhanhu

doi:10.1007/s42114-022-00478-3

Cited by 84 publications

(61 citation statements)

References 97 publications

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“…The applied voltages are often between 5 and 30 kV. Syringe pumps are exploited to drive the working fluids to the spinneret in a quantitative manner ( Liu et al, 2022c ; Liu et al, 2022a ). The spinneret is the most innovative section in an electrospinning apparatus ( Wang M. et al, 2022 ; Liu et al, 2022b ).…”

Section: Electrospun Glucose Sensorsmentioning

confidence: 99%

“…Syringe pumps are exploited to drive the working fluids to the spinneret in a quantitative manner ( Liu et al, 2022c ; Liu et al, 2022a ). The spinneret is the most innovative section in an electrospinning apparatus ( Wang M. et al, 2022 ; Liu et al, 2022b ). In the literature, the spinneret is relied on to determine what kinds of electrospinning processes are used; for example, a mono-axial spinneret leads to a single-fluid blending electrospinning, a concentric spinneret is used for a coaxial electrospinning, an eccentric spinneret is used for a side-by-side electrospinning process, and spinnerets with complicated structures are used for multiple-fluid processes ( Kang et al, 2022 ; Liu et al, 2022e ; Liu et al, 2022d ).…”

Section: Electrospun Glucose Sensorsmentioning

confidence: 99%

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Electrospun nanofiber-based glucose sensors for glucose detection

Zhang

Liu

et al. 2022

Front. Chem.

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Diabetes is a chronic, systemic metabolic disease that leads to multiple complications, even death. Meanwhile, the number of people with diabetes worldwide is increasing year by year. Sensors play an important role in the development of biomedical devices. The development of efficient, stable, and inexpensive glucose sensors for the continuous monitoring of blood glucose levels has received widespread attention because they can provide reliable data for diabetes prevention and diagnosis. Electrospun nanofibers are new kinds of functional nanocomposites that show incredible capabilities for high-level biosensing. This article reviews glucose sensors based on electrospun nanofibers. The principles of the glucose sensor, the types of glucose measurement, and the glucose detection methods are briefly discussed. The principle of electrospinning and its applications and advantages in glucose sensors are then introduced. This article provides a comprehensive summary of the applications and advantages of polymers and nanomaterials in electrospun nanofiber-based glucose sensors. The relevant applications and comparisons of enzymatic and non-enzymatic nanofiber-based glucose sensors are discussed in detail. The main advantages and disadvantages of glucose sensors based on electrospun nanofibers are evaluated, and some solutions are proposed. Finally, potential commercial development and improved methods for glucose sensors based on electrospinning nanofibers are discussed.

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Section: Electrospun Glucose Sensorsmentioning

confidence: 99%

Section: Electrospun Glucose Sensorsmentioning

confidence: 99%

Electrospun nanofiber-based glucose sensors for glucose detection

Zhang

Liu

et al. 2022

Front. Chem.

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“…This new electrospinning structure is able to release drugs according to different pH and is an intelligent responsive three-phase drug release system, which has good prospects for application in the field of controlled drug release. Along this way, some brand-new electrospun nanostructures can be further developed for biomedical applications [ 79 ].…”

Section: Electrospinning Technologymentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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“…Electrospinning, as an electrohydrodynamic technique, is broadly exploited to treat cellulose and its derivatives for biomedical and other applications [ 36 , 37 , 38 ]. There are numerous research publications and many review articles about this topic [ 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Liu

Zhang

Song

et al. 2022

Gels

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The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.

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Electrospun structural nanohybrids combining three composites for fast helicide delivery

Cited by 84 publications

References 97 publications

Electrospun nanofiber-based glucose sensors for glucose detection

Electrospun nanofiber-based glucose sensors for glucose detection

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

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