Electrospun Sesbania Gum-Based Polymeric N-Halamines for Antibacterial Applications

Abstract

Microorganism pollution induced by pathogens has become a serious concern in recent years. In response, research on antibacterial N-halamines has made impressive progress in developing ways to combat this pollution. While synthetic polymer-based N-halamines have been widely developed and in some cases even commercialized, N-halamines based on naturally occurring polymers remain underexplored. In this contribution, we report for the first time on a strategy for developing sesbania gum (SG)-based polymeric N-halamines by a four-step approach Using SG as the initial polymer, we obtained SG-based polymeric N-halamines (abbreviated as cSG-PAN nanofibers) via a step-by-step controllable synthesis process. With the assistance of advanced techniques, the as-synthesized cSG-PAN nanofibers were systematically characterized in terms of their chemical composition and morphology. In a series of antibacterial and cytotoxicity evaluations, the as-obtained cSG-PAN nanofibers displayed good antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as low cytotoxicity towards A549 cells. We believe this study offers a guide for developing naturally occurring polymer-based antibacterial N-halamines that have great potential for antibacterial applications.

Antibacterial and antiviral N-halamine nanofibrous membranes with nanonet structure for bioprotective applications

“…What is noteworthy is that the introduction of quaternary ammonium salt had the following advantages: (i) increasing the chlorine content from 790 ppm to 6030 ppm because enhanced hydrophilicity of nanofiber materials facilitated the grafting of N -halamine；(ii) changing conductivity of the polymer solution, thus enabling the polymer to be drawn into multi-level nanometer structure containing nanofiber with a diameter of 199 ± 55 nm and nanonets with a diameter of 38 ± 7 nm; (iii) prolong the service life of the materials as a supplementary and stable biocidal group . Plentiful previous researches showed that the antimicrobial material containing N -halamine or quaternary ammonia salt group showed no cytotoxicity [ [26] , [27] , [28] ].…”

The Role of Electrospun Nanomaterials in the Future of Energy and Environment

“…Polyacrylonitrile-activated biochar-laccase composite membrane (PAN-BC-LAC) was used as the biocatalytic middle layer for eliminating micropollutants (99% efficiency) and finally an adsorptive membrane enabled reducing color and turbidity. In another study, modification of natural polysaccharide Sesbania gum (SG) was carried out through epoxidation, amination, and chlorination [ 246 ]. Nanofibers of chlorinated SG was then fabricated by electrospinning using polyacrylonitrile (PAN) as the support matrix.…”

Anchoring Guanidine Polymer onto Sesbania Gum to Endow Excellent Antibacterial Function

“…Although there are some researches on SG in the past several decades, most of them focused on its basic research, and its applications were rarely reported. [ 42–44 ]…”

“…Although there are some researches on SG in the past several decades, most of them focused on its basic research, and its applications were rarely reported. [42][43][44] In this contribution, the guanidine polymer was anchored onto sesbania gum through a two-step approach for antibacterial application (Figure 1). Firstly, the o-hydroxyl group on the surface of sesbania gum was oxidized by sodium periodate to achieve the oxidized sesbania gum (OSG).…”