Electrospun PVA nanoscaffolds associated with propolis nanoparticles with wound healing activity

Alberti, Thaís; Coelho, Daniela; Prá, Manuel de; Maraschin, Marcelo; Veleirinho, Beatriz

doi:10.1007/s10853-020-04502-z

Cited by 47 publications

(41 citation statements)

References 67 publications

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“…In recent years, many researchers have become interested in developing bionanomaterials using bee products [ 4 ]. The use of bee products, such as honey [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ] and propolis [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], for developing nanofibrous biomedical applications has been studied extensively. Bee pollen is another bee product that may well influence human health.…”

Section: Introductionmentioning

confidence: 99%

Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Pakolpakçıl

Draczyński

2021

Materials

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Green electrospun materials are gaining popularity in the quest for a more sustainable environment for human life. Bee pollen (BP) is a valuable apitherapeutic product and has many beneficial features such as antioxidant and antibacterial properties. Alginate is a natural and low-cost polymer. Both natural materials show good compatibility with human tissues for biomedical applications and have no toxic effect on the environment. In this study, bee pollen-loaded sodium alginate and polyvinyl alcohol (SA/PVA) nanofibrous mats were fabricated by the electrospinning technique. The green electrospun nanofibrous mats were analyzed by scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), and differential scanning calorimeter (DSC). According to the findings of the study, the toxin-free electrospinning method is suitable for producing green nanomaterial. Because of the useful properties of the bee pollen and the favorable biocompatibility of the alginate fibers, the bee pollen-loaded SA/PVA electrospun mats have the potential for use in a variety of biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Pakolpakçıl

Draczyński

2021

Materials

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“…Nano-scaffolds, or better elaborated as nanofibrous scaffolds, are nano-systems premeditated to resemble the components of the cellular microenvironment or to reorientate cell behavior. The predicted tendency is to use biodegradable biomaterials, which help regenerate and repair damaged tissue [ 128 ]. With advanced tissue engineering tools such as nano-architectonics approaches, in which materials are designed taking into account methods including organic synthesis, self-assembly/self-organization, molecular manipulation, and structural regulation upon stimuli, scaffolds are being tailor-made to have good biodegradability, mechanical properties, and ease in processing some polymers to better fit into different tissue engineering arenas.…”

Section: Prospective Technologies Of Wound Healingmentioning

confidence: 99%

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Banerjee

Madhyastha

Nakajima

et al. 2021

IJMS

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Dermal wound healing describes the progressive repair and recalcitrant mechanism of 12 damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Bioengineered alternative agents will likely continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new products continue to cut costs and improve the wound healing process. This review article provides an update on the various remedies with confirmed wound healing activities of metal-based nanoceutical adjuvanted agents and also other nano-based counterparts from previous experiments conducted by various researchers.

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“…In the case of non-compressible type of wounds, elasticity is another important requirement for a dressing to avoid wound compression. In addition, the wound dressing material should be soft, biocompatible, non-toxic, and non-allergenic [19,[26][27][28]. The effective healing process will improve by applying multifunctional wound dressings.…”

Section: Introductionmentioning

confidence: 99%

“…Nanofibrous scaffolds with appropriate mechanical properties could be proper substrates for cell proliferation. Besides, the incorporation of therapeutic and pharmaceutical agents is used to functionalize electrospun dressings for efficiently targeting different wound types [12,27,[31][32][33][34].…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

146

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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Electrospun PVA nanoscaffolds associated with propolis nanoparticles with wound healing activity

Cited by 47 publications

References 67 publications

Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Green Approach to Develop Bee Pollen-Loaded Alginate Based Nanofibrous Mat

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Bio-Based Electrospun Fibers for Wound Healing

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