Electrospun PVA Fibers for Drug Delivery: A Review

Abstract

Innovation in biomedical science is always a field of interest for researchers. Drug delivery, being one of the key areas of biomedical science, has gained considerable significance. The utilization of simple yet effective techniques such as electrospinning has undergone significant development in the field of drug delivery. Various polymers such as PEG (polyethylene glycol), PLGA (Poly(lactic-co-glycolic acid)), PLA(Polylactic acid), and PCA (poly(methacrylate citric acid)) have been utilized to prepare electrospinning-based drug delivery systems (DDSs). Polyvinyl alcohol (PVA) has recently gained attention because of its biocompatibility, biodegradability, non-toxicity, and ideal mechanical properties as these are the key factors in developing DDSs. Moreover, it has shown promising results in developing DDSs individually and when combined with natural and synthetic polymers such as chitosan and polycaprolactone (PCL). Considering the outstanding properties of PVA, the aim of this review paper was therefore to summarize these recent advances by highlighting the potential of electrospun PVA for drug delivery systems.

Streamlining the highly reproducible fabrication of fibrous biomedical specimens towards standardization and high throughput

“…1a, b). 29,30 Moreover, if combined with laser cutting, PVA is crucial for a seamless removal from the substrate, as otherwise the polymer fuses to the substrate at the cut edges. The coating functions as a separation, which is then dissolved, and the scaffold released, also offering the advantage of combining the washing steps and sterilization for cell culture if done in 70% ethanol.…”

Preparation and Characterization of Electrospun EVOH/Ti3C2 Composite Fibers

“…Electrospinning is a straightforward and prominent technique for the one-step preparation of nanoscale polymeric fibers, which has been extensively applied in drug delivery [ 1 , 2 ], energy storage [ 3 , 4 ], filtration [ 5 , 6 ], tissue engineering [ 7 , 8 ], separation and absorption [ 9 , 10 ]. In view of the wide range of spinnable materials and convenient modifications available within electrospinning, electrospun composite fibers have enormously expanded the versatility of electrospinning in the fields of textile, aerospace, agriculture, biology, defense and security [ 11 , 12 ] due to their high specific surface area, high porosity and interconnected pores [ 13 , 14 ].…”

Formulation and Evaluation of Transdermal Patches Containing BGP-15

“…PVA is a copolymer of vinyl acetate and vinyl alcohol that is widely utilized in pharmaceutical formulations for its biocompatible, non-toxic and hydrophilic properties [ 13 , 14 , 15 ]. The extensive use of PVA is dictated by its beneficial properties, such as outstanding film-forming capability, impressive adhesive and emulsifying characteristics, chemical resistance and mechanical stability.…”