Electrospun polyvinyl alcohol membranes incorporated with green synthesized silver nanoparticles for wound dressing applications

Augustine, Robin; Hasan, Anwarul; Nath, Vishwa; Thomas, Jince; Augustine, Anitha; Kalarikkal, Nandakumar; Moustafa, Ala‐Eddin Al; Thomas, Sabu

doi:10.1007/s10856-018-6169-7

Cited by 88 publications

(43 citation statements)

References 56 publications

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“…PVA polymer has either been used alone or combined with other biodegradable polymers and electrospun to form scaffolds for various applications. Furthermore, PVA has also been blended and electrospun with active ingredients such as hyaluronic acid/L-arginine, soursop leaves extract, silver nanoparticles and curcumin for wound healing [ 28 , 29 , 30 , 31 ]. Recently, we have developed, for the first time, a PVA bioactive wound dressing containing TE which showed accelerated wound healing [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Mwiiri

Daniels

2020

Molecules

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Triterpenes from the outer bark of birch (TE) are known for various pharmacological effects including enhanced wound healing. Apart from an already authorized oleogel, electrospun nanofiber mats containing these triterpenes in a polyvinyl alcohol (PVA) matrix appear to be an advantageous application form. The effects of PVA molecular weight and concentration on the fiber morphology have been investigated. Three different molecular weights of PVA ranging from 67 to 186 kDa were used. The concentration of PVA was varied from 5 to 20 wt%. Polymer solutions were blended with colloidal dispersions of birch bark extract at a weight ratio of 60:40 (wt.%). The estimated viscosity of polymer solutions was directly linked to their concentration and molecular weight. In addition, both pure and blended solutions showed viscoelastic properties with a dominant viscous response in the bulk. Fiber morphology was confirmed using scanning electron microscopy (SEM). Both polymer concentration and molecular weight were found to be significant factors affecting the diameter of the fibers. Fiber diameter increased with a higher molecular weight and polymer concentration as more uniform fibers were obtained using PVA of higher molecular weight (146–186 kDa). In vitro drug release and ex vivo permeation studies indicated a faster drug release of betulin from electrospun scaffolds with lower PVA molecular weight. Our research suggests that the fabricated TE-loaded PVA electrospun dressings represent potential delivery systems of TE for wound care applications.

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Section: Introductionmentioning

confidence: 99%

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Mwiiri

Daniels

2020

Molecules

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“…PVA is a biocompatible and biodegradable hydrophilic polymer with good chemical and mechanical properties, and has been approved by the U. S. Food and Drug Administration (FDA) for different biomedical and pharmaceutical applications [ 27 , 28 ]. For instance, PVA has been used to create hydrogels for wound dressing [ 29 ] or electrospun together with active substances, such as silver nanoparticles [ 30 ], and curcumin [ 31 ], to produce wound dressings. Several wound dressings in the market containing active agents such as hydrocolloids or silver dressings often used on wound healing have shown negative effects such as allergic contact dermatitis [ 32 ], and use of dressings loaded with antibiotics has risk of developing antimicrobial resistance [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

2020

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Novel birch bark dry extract (TE)-loaded polyvinyl alcohol (PVA) fiber mats intended for wound therapy were developed through an electrospinning process. Colloidal dispersions containing TE as the active substance were prepared by the high-pressure homogenization (HPH) technique using hydrogenated phospholipids as stabilizer. Subsequently, the colloidal dispersions were blended with aqueous PVA solutions in the ratio of 60:40 (wt.%) and electrospun to form the nanofiber mats. Fiber morphology examined using scanning electron microscopy (SEM) indicated that fibers were uniform and achieved diameters in the size range of 300–1586 nm. Confocal Raman spectral imaging gave good evidence that triterpenes were encapsulated within the electrospun mats. In vitro drug release and ex vivo permeation studies indicated that the electrospun nanofibers showed a sustained release of betulin, the main component of birch bark dry extract, making the examined dressings highly applicable for several wound care applications. Ex vivo wound healing studies proved that electrospun fiber mats containing TE accelerated wound healing significantly more than TE oleogel, which was comparable to an authorized product that consists of TE and sunflower oil and has proved to enhance wound healing. Therefore, our results conclude that the developed TE-PVA-based dressings show promising potential for wound therapy, an area where effective remedy is needed.

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“…The rise in water absorption is mainly due to the nanofillers. It is known that the nano‐sized filler has high surface area to volume ratio leading to a large porosity and specific area to absorb water . Additionally, nanofillers are hydrophilic which tend to absorb moisture from the air naturally leading to the hydroxyl groups surrounded the nanoparticles.…”

Section: Resultsmentioning

confidence: 99%

Properties of nanofillers/crosslinked polyethylene composites for cable insulation

Lim

Mariatti

Jamil

et al. 2018

Vinyl Additive Technology

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In this work, we report the effect of nanofillers and filler loading on mechanical, physical, dielectric, and thermal properties of the crosslinked polyethylene (XLPE) matrix. XLPE filled with 0.5-2% of zinc oxide (ZnO), aluminium oxide (Al 2 O 3 ), and organoclay (OMMT) nanofillers prepared by melt mixing with a single screw extruder followed by hot press moulding. Nanocomposites were tested as per ASTM standard methods and characterized with tensile test, water absorption, linear rate of burning, dielectric breakdown strength, and thermal stability. Scanning electron microscopy (SEM) was used to examine the surface morphology of the nanocomposites. The results showed that addition of nanofillers improved tensile strength, elongation at break, Young's modulus, burning rate, dielectric breakdown strength, and decomposition temperature. However, water absorption increased with time due to the hydrophilic properties of nanofillers. In general, based on the properties measured Al 2 O 3 exhibits the highest properties than those of ZnO and OMMT nanofillers. Addition of 1.5% of Al 2 O 3 in XLPE matrix has led to the improvement in tensile strength, elongation at break, Young's modulus, burning rate, and dielectric breakdown strength as compared to the unfilled polymer. J. VINYL ADDIT. TECHNOL., 25: E147-E154, 2019.

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Electrospun polyvinyl alcohol membranes incorporated with green synthesized silver nanoparticles for wound dressing applications

Cited by 88 publications

References 56 publications

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Influence of PVA Molecular Weight and Concentration on Electrospinnability of Birch Bark Extract-Loaded Nanofibrous Scaffolds Intended for Enhanced Wound Healing

Electrospun Bioactive Wound Dressing Containing Colloidal Dispersions of Birch Bark Dry Extract

Properties of nanofillers/crosslinked polyethylene composites for cable insulation

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