Electrospun Polymer Nanofibers with Antimicrobial Activity

Maliszewska, Irena; Czapka, Tomasz

doi:10.3390/polym14091661

Cited by 83 publications

(59 citation statements)

References 217 publications

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“…Electrospinning involves converting a liquid polymer solution into solid nanofibers by applying an electrical force in the presence of a strong electric field [ 77 ]. Interestingly, electrospun nanofibers materials based on synthetic and natural antibacterial polymers have been studied due to their biocompatibility, biodegradability, and non-toxicity [ 83 , 84 ]. On the other hand, 3D printing is a relatively new, rapidly expanding method of manufacturing that allows the formation of 3D compact structures with desired and predefined architecture [ 85 ].…”

Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to multiple antibiotic treatments, causing a crisis in the health sector. Furthermore, the World Health Organization has listed a series of pathogens (ESKAPE group) that have acquired new and varied resistance to different antibiotics families. Therefore, the scientific community has prioritized designing and developing novel treatments to combat these ESKAPE pathogens and other emergent multidrug-resistant bacteria. One of the solutions is the use of combinatorial therapies. Combinatorial therapies seek to enhance the effects of individual treatments at lower doses, bringing the advantage of being, in most cases, much less harmful to patients. Among the new developments in combinatorial therapies, nanomaterials have gained significant interest. Some of the most promising nanotherapeutics include polymers, inorganic nanoparticles, and antimicrobial peptides due to their bactericidal and nanocarrier properties. Therefore, this review focuses on discussing the state-of-the-art of the most significant advances and concludes with a perspective on the future developments of nanotherapeutic combinatorial treatments that target bacterial infections.

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Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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“…The search has begun in this decade, and metal-based nanoparticles (NPs) have aroused some interest in the research fraternity, and these novel molecules are an appropriate agent for investigation [13]. In addition to this, NPs of diverse materials are gaining great importance in therapeutic use [14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Therapeutic Efficacy of Copper Nanoparticles in Staphylococcus aureus‐Induced Rat Mastitis Model

Taifa

Muhee

Bhat

et al. 2022

Journal of Nanomaterials

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The current study was devised to develop alternative, nonantibiotic, and economically viable treatments for bovine mastitis. The concentration of 6.25 μg/mL (25 nm) CuNPs was selected as intramammary (IM) treatment in S. aureus-induced mastitis in rats as this concentration showed a significant zone of inhibition through the in vitro sensitivity test and minimal cell toxicity on fibroblast cell lines. After, this in vivo study was conducted, and rats were divided into four groups of 6 rats each: group I (healthy control/deionized water), group II (disease control), group III (CuNPs), and group IV (gentamicin). Injection of gentamicin IM for 5 days was selected on the basis of an antibiotic sensitivity test. The therapeutic efficacy of CuNPs was assessed on the basis of clinical signs, mammary gland architecture, bacterial load, oxidative stress parameters, and histopathology of mammary glands. The clinical signs of mastitis in group III ameliorated within 3 days of treatment while in group IV clinical signs ameliorated within 4 days of initiation of treatment. On the 5th day after randomization, bacterial load, mammary gland weights, TOS (Total Oxidant Status), and OSI (oxidative stress index) were significantly lower in the CuNPs group compared to the disease control group and commercial antibiotic group. Similarly, TAS of group III was significantly higher compared to that of groups II and IV indicating that CuNPs have better ameliorative efficacy in mastitis. Treatment with IM, CuNPs @ 6.25 μg/mL showed early recovery, reduced bacterial loads, and amelioration of oxidative stress indices henceforth resulting in marked amelioration in histopathological changes compared to rats in group IV. From this study, it may be concluded that CuNPs may provide a potential alternative therapeutic regimen for the treatment of bovine mastitis.

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“…The incorporation of antimicrobial agents into biomaterials could help to combat these problems. [ 4–9 ] In the design of such products for clinical applications, biodegradable and biocompatible polymers, including polylactic acid (PLA), polycaprolactone (PCL), poly(glycolic acid) (PGA), or poly(butylene adipate‐ co ‐terephthalate) (PBAT), are gaining increased importance as they metabolize in human body into biocompatible degradation products, and second surgery for removal is unnecessary. [ 10,11 ]…”

Section: Introductionmentioning

confidence: 99%

PLA and PBAT‐Based Electrospun Fibers Functionalized with Antibacterial Bio‐Based Polymers

Chiloeches

Fernández-García

Mariano

et al. 2022

Macromolecular Bioscience

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Antimicrobial fibers based on biodegradable polymers, poly(lactic acid) (PLA), and poly(butylene adipate‐co‐terephthalate) (PBAT) are prepared by electrospinning. For this purpose, a biodegradable/bio‐based polyitaconate containing azoles groups (PTTI) is incorporated at 10 wt.% into the electrospinning formulations. The resulting fibers functionalized with azole moieties are uniform and free of beads. Then, the accessible azole groups are subjected to N‐alkylation, treatment that provides cationic azolium groups with antibacterial activity at the surface of fibers. The positive charge density, roughness, and wettability of the cationic fibers are evaluated and compared with flat films. It is confirmed that these parameters exert an important effect on the antimicrobial properties, as well as the length of the alkylating agent and the hydrophobicity of the matrix. The quaternized PLA/PTTI fibers exhibit the highest efficiency against the tested bacteria, yielding a 4‐Log reduction against S. aureus and 1.7‐Log against MRSA. Then, biocompatibility and bioactivity of the fibers are evaluated in terms of adhesion, morphology and viability of fibroblasts. The results show no cytotoxic effect of the samples, however, a cytostatic effect is appreciated, which is ascribed to the strong electrostatic interactions between the positive charge at the fiber surface and the negative charge of the cell membranes.

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Electrospun Polymer Nanofibers with Antimicrobial Activity

Cited by 83 publications

References 217 publications

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

Evaluation of Therapeutic Efficacy of Copper Nanoparticles in Staphylococcus aureus‐Induced Rat Mastitis Model

PLA and PBAT‐Based Electrospun Fibers Functionalized with Antibacterial Bio‐Based Polymers

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