Electrospun polyethylene terephthalate/graphene oxide nanofibrous membrane followed by HPLC for the separation and determination of tamoxifen in human blood plasma

Abstract

An electrospun polyethylene terephthalate/graphene oxide nanofibrous mat was fabricated and used as an effective and novel membrane for the solid-phase extraction of tamoxifen in human blood plasma samples before detection by high-performance liquid chromatography. The membrane was characterized by some identification techniques, such as FTIR spectroscopy, X-ray diffraction, and scanning electron microscopy. The effective variables of the extraction procedure including desorption condition (type and volume of the eluent), adsorbent dose, pH of sample solution, salt concentration, and sample loading time were investigated and their optimum values were obtained using one factor at a time methodology. Under the optimized conditions, the results showed wide linear concentration range of 5-2000 ng/mL with a determination coefficient of 0.992. The limits of detection and limits of quantification were 1.3 and 5.0 ng/mL, respectively. The intra-day and inter-day precisions were 3.4 and 4.6%, respectively. The method was successfully applied to determination of tamoxifen in the blood plasma samples and satisfactory relative recoveries (92.6-98.3 %) were achieved.

Production of 2‐hydroxyethyl methacrylate‐g‐poly(ethylene terephthalate) nanofibers by electrospinning and evaluation of the properties of the obtained nanofibers

“…After a specified time, PET and PET-g-HEMA nanofibers were removed from the aluminum foil in methanol and dried at room temperature. [33,34]…”

Preparation of Cerium Oxide-MWCNTs Nanocomposite Bulk Modified Carbon Ceramic Electrode: A Sensitive Sensor for Tamoxifen Determination in Human Serum Samples

“…To date, various analytical methods have been used to determine TAM including high-performance liquid chromatography, spectro uorimetry, spectrophotometry, capillary electrophoresis, voltammetry and etc. [2][3][4][5][6][7][8]. Among these methods, electrochemical techniques are broadly used because of their high sensitivity, rapidity, ease of operation, low cost and miniaturization capability.…”

Monitoring of priority pollutants chlorophenols in water and milk by headspace solid‐phase microextraction based on electrospun polycaprolactam nanofibers decorated with cadmium oxide‐carbon nanotubes

“…The electrospun polymer nanofibers with remarkable properties such as large specific surface area, high porosity, and simple fabrication procedure have been used as an adsorbent in HS‐SPME. These materials are fabricated with the electrospinning technique by applying a high voltage electric field to an appropriate polymer solution [11,15,16].…”