Electrospun Poly(Amino Acid) Based Nano GEL Fiber Matrices and Their Biocompatibility and Biodegradability

Molnár, Kristóf; Voniatis, Constantinos; Fehér, D.; Ferencz, Andrea; Wéber, György; Zrı́nyi, Miklós; Jedlovszky-Hajdú, Angéla

doi:10.1016/j.bpj.2017.11.2013

Cited by 3 publications

(3 citation statements)

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“…Some other studies also demonstrated that the spinnability of PASP was relatively inferior to some synthetic polymers, such as polycaprolactone (PCL) and PLGA, leading to an increase of the fiber diameter when a higher PASP content was used. [31,32]…”

Section: Morphological Analysis Of Electrospun Nanofibrous Scaffoldsmentioning

confidence: 99%

Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets

Zhang

et al. 2022

Adv Healthcare Materials

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3D heterogeneous and anisotropic scaffolds that approximate native heart valve tissues are indispensable for the successful construction of tissue engineered heart valves (TEHVs). In this study, novel tri-layered and gel-like nanofibrous scaffolds, consisting of poly(lactic-co-glycolic) acid (PLGA) and poly(aspartic acid) (PASP), are fabricated by a combination of positive/negative conjugate electrospinning and bioactive hydrogel post-processing. The nanofibrous PLGA-PASP scaffolds present tri-layered structures, resulting in anisotropic mechanical properties that are comparable with native heart valve leaflets. Biological tests show that nanofibrous PLGA-PASP scaffolds with high PASP ratios significantly promote the proliferation and collagen and glycosaminoglycans (GAGs) secretions of human aortic valvular interstitial cells (HAVICs), compared to PLGA scaffolds. Importantly, the nanofibrous PLGA-PASP scaffolds are found to effectively inhibit the osteogenic differentiation of HAVICs. Two types of porcine VICs, from young and adult age groups, are further seeded onto the PLGA-PASP scaffolds. The adult VICs secrete higher amounts of collagens and GAGs and undergo a significantly higher level of osteogenic differentiation than young VICs. RNA sequencing analysis indicates that age has a pivotal effect on the VIC behaviors. This study provides important guidance and a reference for the design and development of 3D tri-layered, gel-like nanofibrous PLGA-PASP scaffolds for TEHV applications.

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Section: Morphological Analysis Of Electrospun Nanofibrous Scaffoldsmentioning

confidence: 99%

Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets

Zhang

et al. 2022

Adv Healthcare Materials

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“…The volume of the grain is calculated as if the grain was spherical, but its surface area is calculated by Eqs. [3] and [4] with the average value of k = 3.36 (see above).…”

Section: Selection Of Models and Parameters To Demonstrate The Smentioning

confidence: 99%

“…NANO-MATERIALS play an increasing scientific and social role. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] In the past, nano-materials were simplified to single nano-particles. However, it has been clear for some decades that the real use of nanomaterials is expected if they form macroscopic articles with nano-structure inside.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Stability of Nano-grained Alloys Against Grain Coarsening and Precipitation of Macroscopic Phases

Kaptay

2019

Metall Mater Trans A

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Thermodynamic conditions are derived here for binary alloys to have their grain boundary (GB) energies negative, ensuring the stability of some nano-grained (NG) alloys. All binary alloys are found to belong to one of the following three types. Type 1 is the unstable NG alloy both against grain coarsening and precipitation of a macro-phase. Type 2 is the partly stable NG alloy, stable against coarsening but not against precipitation. Type 3 is the fully stable NG alloy, both against coarsening and precipitation. Alloys type 1 have negative, or low-positive interaction energies between the components. Alloys type 2 have medium-positive interaction energies, while alloys type 3 have high-positive interaction energies. Equations are derived for critical interaction energies separating alloys type 1 from type 2 and those from type 3, being functions of the molar excess GB energy of the solute, temperature (T) and composition of the alloy. The criterion to form a stable NG alloy is formulated through a new dimensionless number (Ng), defined as the ratio of the interaction energy to the excess molar GB energy of the solute, both taken at zero Kelvin. Systems with Ng number below 0.6 belong to alloy type 1, systems with Ng number between 0.6 and 1 belong to alloy type 2, while systems with Ng number above 1 belong to alloy type 3, at least at T = 0 K. The larger is the Ng number, the higher is the maximum T of stability of the NG alloy. By gradually increasing temperature alloys type 3 convert first into type 2 and further into type 1. The Ng number is used here to evaluate 16 binary tungsten-based (W-B) alloys. At T = 0 K type 3 NG alloys are formed with B = Cu, Ag, Mn, Ce, Y, Sc, Cr; type 2 is formed in the W-Ti system, while type 1 alloys are formed with B = Al, Ni, Co, Fe, Zr, Nb, Mo and Ta. For the WAg system the region of stability of the NG alloys is shown on a calculated phase diagram, indicating also the stable grain size.

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Modelling surface melting of macro-crystals and melting of nano-crystals for the case of perfectly wetting liquids in one-component systems using lead as an example

Vegh

Kaptay

2018

Calphad

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Electrospun Poly(Amino Acid) Based Nano GEL Fiber Matrices and Their Biocompatibility and Biodegradability

Cited by 3 publications

References 0 publications

Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets

Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve Leaflets

Thermodynamic Stability of Nano-grained Alloys Against Grain Coarsening and Precipitation of Macroscopic Phases

Modelling surface melting of macro-crystals and melting of nano-crystals for the case of perfectly wetting liquids in one-component systems using lead as an example

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