Electrospun piezoelectric scaffolds for cardiac tissue engineering

Gomes, Mariana Ramalho; Ferreira, Frederico Castelo; Sanjuán-Alberte, Paola

doi:10.1016/j.bioadv.2022.212808

Cited by 16 publications

(12 citation statements)

References 164 publications

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“…In addition, piezoelectric materials can also be used to construct cardiac tissue scaffolds that can simulate the mechanoelectrical transduction of the heart and convert mechanical stress from the contraction of cardiac tissue into electrical stimulation applied to cardiac cells. [111][112][113] PVDF and PVDF-TrFE-based electrospun fiber scaffolds were also demonstrated to have the ability to maintain CM contraction over time, sense contractions of cardiac tissues, support cellular adhesion and alignment, and promote cardiac differentiation and maturation of cardiac cells. [113][114][115][116] Currently, NGs have only recently been used in the exploration of cardiac tissue repair; hence, there is great potential and opportunity for innovation in this field.…”

Section: Pengmentioning

confidence: 99%

Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases

Zhao

Wong

Sim

et al. 2023

BMEMat

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Heart diseases pose a serious threat to human health, and their incidence has been increasing in recent years. In past decades, many strategies have been developed to decrease the mortality and morbidity of heart diseases, among them, strategies involving cardiac electronic devices (CEDs) have been effective in treating and preventing heart diseases. To allow the CEDs to work continuously without the need to replace batteries and to meet the requirements of convenience and comfort in the process of use, nanogenerator (NG)-based CEDs were proposed, widely studied, continuously optimized in recent years owing to their advantages of small dimensions, self-powering ability, and good biocompatibility. In this review, recent improvements of NG-based CEDs of two typical types (i.e., triboelectric nanogenerator [TENG] and piezoelectric nanogenerator [PENG]) and their structures and functions are summarized and discussed. The demands, remaining challenges, and future development trends of NG-based CEDs are also discussed.

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Section: Pengmentioning

confidence: 99%

Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases

Zhao

Wong

Sim

et al. 2023

BMEMat

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“…More importantly, the cardiac scaffolds could not only serve as repairing material, but also appropriate candidates for assessing the functionality of engineered cardiac tissues before and after transplantation, through embedding sensors or directly employing stimuli-responsive raw materials for scaffold construction. 58 For this purpose, Adadi et al proposed an electrospinning scaffold composed of piezoelectric poly-(vinylidene fluoride) (PVDF) material as schemed in Figure 3D. 57 Such scaffold with aligned PVDF fibers was utilized for the differentiation of iPSCs into cardiomyocytes and induced their alignment.…”

Section: Electrospinningmentioning

confidence: 99%

Section: Fabrication Techniquesmentioning

confidence: 99%

Emerging technologies for cardiac tissue engineering and artificial hearts

Sun

Wang

et al. 2023

Smart Medicine

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Heart diseases, especially cardiovascular diseases, have brought heavy burden on society for their high morbidity and mortality. In clinical, heart transplantation is recognized as an effective strategy to rescue the lives of patients, while it may suffer from lack of donors and possible immune responses. In view of this, tremendous efforts have been devoted to developing alternative strategies to recover the function and promote the regeneration of cardiac tissues. As an emerging field blending cell biology and material science, tissue engineering technique allows the construction of biomimetic living complexes as organ substitutes for heart repair. In this review, we will present the recent progress in cardiac tissue engineering and artificial hearts. After introducing the critical elements in cardiac tissue engineering, we will present advanced fabrication methods to achieve scaffolds with desired micro/nanostructure design as well as the applications of these bioinspired scaffolds. We will also discuss the current dilemma and possible development direction from a biomedical perspective.

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“…Electrospinning is a technique that has been widely investigated in the engineering of multiple tissues such as bone [ 8 ], skin [ 9 ] or cardiac tissues [ 10 ]. However, it still remains largely unexplored in kidney TE.…”

Section: Introductionmentioning

confidence: 99%

A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering

et al. 2022

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Chronic kidney disease is one of the deadliest diseases globally and treatment methods are still insufficient, relying mostly on transplantation and dialysis. Engineering of kidney tissues in vitro from induced pluripotent stem cells (iPSCs) could provide a solution to this medical need by restoring the function of damaged kidneys. However, implementation of such approaches is still challenging to achieve due to the complexity of mature kidneys in vivo. Several strategies have been defined to obtain kidney progenitor endothelial and epithelial cells that could form nephrons and proximal tube cells, but these lack tissue maturity and vascularisation to be further implemented. Electrospinning is a technique that has shown promise in the development of physiological microenvironments of several tissues and could be applied in the engineering of kidney tissues. Synthetic polymers such as polycaprolactone, polylactic acid, and poly(vinyl alcohol) have been explored in the manufacturing of fibres that align and promote the proliferation and cell-to-cell interactions of kidney cells. Natural polymers including silk fibroin and decellularised extracellular matrix have also been explored alone and in combination with synthetic polymers promoting the differentiation of podocytes and tubular-specific cells. Despite these attempts, further work is still required to advance the applications of electrospun fibres in kidney tissue engineering and explore this technique in combination with other manufacturing methods such as bioprinting to develop more organised, mature and reproducible kidney organoids.

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Electrospun piezoelectric scaffolds for cardiac tissue engineering

Cited by 16 publications

References 164 publications

Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases

Triboelectric nanogenerators and piezoelectric nanogenerators for preventing and treating heart diseases

Emerging technologies for cardiac tissue engineering and artificial hearts

A Concise Review on Electrospun Scaffolds for Kidney Tissue Engineering

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