2014
DOI: 10.1002/adhm.201300505
|View full text |Cite
|
Sign up to set email alerts
|

Electrospun PGS:PCL Microfibers Align Human Valvular Interstitial Cells and Provide Tunable Scaffold Anisotropy

Abstract: Tissue engineered heart valves (TEHV) could be useful in the repair of congenital or acquired valvular diseases due to their potential for growth and remodeling. The development of biomimetic scaffolds is a major challenge in heart valve tissue engineering. One of the most important structural characteristics of mature heart valve leaflets is their intrinsic anisotropy, which is derived from the microstructure of aligned collagen fibers in the extracellular matrix (ECM). In the present study, we used a directi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

7
69
0

Year Published

2014
2014
2024
2024

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 96 publications
(76 citation statements)
references
References 65 publications
7
69
0
Order By: Relevance
“…However, these constructs lacked a fibrous structure, and the existence of micropores limited their suturability, impeding their application in in vivo studies. To resemble the fibrous structure of native tissues, we recently fabricated electrospun fibrous PGS/poly(caprolactone) (PCL) scaffolds with anisotropic and tunable mechanical properties, including aligned fibers that matched the stiffness of native tissues [38,50]. However, the stress–strain curves for electrospun PGS/PCL scaffolds demonstrated large creep deformation.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, these constructs lacked a fibrous structure, and the existence of micropores limited their suturability, impeding their application in in vivo studies. To resemble the fibrous structure of native tissues, we recently fabricated electrospun fibrous PGS/poly(caprolactone) (PCL) scaffolds with anisotropic and tunable mechanical properties, including aligned fibers that matched the stiffness of native tissues [38,50]. However, the stress–strain curves for electrospun PGS/PCL scaffolds demonstrated large creep deformation.…”
Section: Introductionmentioning
confidence: 99%
“…However, the stress–strain curves for electrospun PGS/PCL scaffolds demonstrated large creep deformation. In addition, the small pore size of these scaffolds (pore size <8 μm) prevented cell migration and ECM deposition through their 3D structures, which limited the formation of a 3D tissue construct [38,50]. …”
Section: Introductionmentioning
confidence: 99%
“…The mechanical properties (elastic modulus, extensibility, and ultimate strength) of PGS can be tuned by blending it with PCL, which is a mechanically strong synthetic polymer [22] . Moreover, our group has recently shown that PGS-PCL mixtures with different compositions can be electrospun to form fibrous scaffolds for tissue engineering applications [23, 24] . The degradation rate of the PGS-PCL substrate is a function of the ratio of the two polymers in the mixtures [23] .…”
mentioning
confidence: 99%
“…However, these printed valves may not have same elastomeric property as a native valve. Recently developed PGS, a biomaterial with high elastomeric property, may fulfill the material properties of the heart valve (Masoumi et al , 2014b). This material may not be printable because it dissolves only in organic solvent such as tetrahydrofuran, which may be harmful for the printing instrument (Rai et al , 2012).…”
Section: Accepted Manuscriptmentioning
confidence: 99%