Electrospun PEO/WPI Nanofibers with Vanillin for Food Applications

Javadi, Bahareh; Mohsenzadeh, Mohammad

doi:10.1007/s11483-024-09832-y

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…Effective, safe, and convenient cancer therapy remains one of the greatest concerns in many medical and clinical fields today ( Chen et al, 2022 ; Murugesan and Raman, 2022 ; Tang et al, 2022 ; Assi et al, 2023 ; Wang et al, 2023d ; Man et al, 2023 ; Meng et al, 2022 ). Numerous active ingredients have been demonstrated for their usefulness through laboratory experiments ( Yang et al, 2024a ; Duan et al, 2024 ; Zhang et al, 2024d ); meanwhile, new types of pharmaceutical excipients (particularly those based on polymers) are being developed continuously ( Lu et al, 2022 ; Shen et al, 2022 ; Ali et al, 2023 ; Yang et al, 2024b ; Zhang et al, 2024e ; Javadi and Mohsenzadeh, 2024 ; Riaz et al, 2024 ), and novel biosourced drug carriers such as exosomes are being considered for DDSs ( Agrawal et al, 2024 ; Guo et al, 2024 ). Combining the advantages of advanced techniques with those of traditional methods to create novel medical materials from these active ingredients and excipients is an evergreen interdisciplinary challenge for researchers.…”

Section: Discussionmentioning

confidence: 99%

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Mao,

Zhou,

Yan

et al. 2024

Front. Bioeng. Biotechnol.

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Combination therapy with oral administration of several active ingredients is a popular clinical treatment for cancer. However, the traditional method has poor convenience, less safety, and low efficiency for patients. The combination of traditional pharmaceutical techniques and advanced material conversion methods can provide new solutions to this issue. In this research, a new kind of hybrid film was created via coaxial electrospraying, followed by a casting process. The films were composed of Reglan and 5-fluorouracil (5-FU)-loaded cellulose acetate (CA) core-shell particles in a polyvinylpyrrolidone (PVP) film matrix. Microscopic observations of these films demonstrated a solid cross section loaded with core-shell particles. X-ray diffraction and Fourier-transform infrared tests verified that the Reglan and 5-FU loaded in the films showed amorphous states and fine compatibilities with the polymeric matrices, i.e., PVP and CA, respectively. In vitro dissolution tests indicated that the films were able to provide the desired asynchronous dual-drug delivery, fast release of Reglan, and sustained release of 5-FU. The controlled release mechanisms were shown to be an erosion mechanism for Reglan and a typical Fickian diffusion mechanism for 5-FU. The protocols reported herein pioneer a new approach for fabricating biomaterials loaded with multiple drugs, each with its own controlled release behavior, for synergistic cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Mao,

Zhou,

Yan

et al. 2024

Front. Bioeng. Biotechnol.

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Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review

Zhang,

Liu,

et al. 2024

Biomolecules

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Alginate is a natural polymer with good biocompatible properties and is a potential polymeric material for the sustainable development and replacement of petroleum derivatives. However, the non-spinnability of pure alginate solutions has hindered the expansion of alginate applications. With the continuous development of electrospinning technology, synthetic polymers, such as PEO and PVA, are used as co-spinning agents to increase the spinnability of alginate. Moreover, the coaxial, parallel Janus, tertiary and other diverse and novel electrospun fiber structures prepared by multi-fluid electrospinning have found a new breakthrough for the problem of poor spinning of natural polymers. Meanwhile, the diverse electrospun fiber structures effectively achieve multiple release modes of drugs. The powerful combination of alginate and electrostatic spinning is widely used in many biomedical fields, such as tissue engineering, regenerative engineering, bioscaffolds, and drug delivery, and the research fever continues to climb. This is particularly true for the controlled delivery aspect of drugs. This review provides a brief overview of alginate, introduces new advances in electrostatic spinning, and highlights the research progress of alginate-based electrospun nanofibers in achieving various controlled release modes, such as pulsed release, sustained release, biphasic release, responsive release, and targeted release.

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Electrospun PEO/WPI Nanofibers with Vanillin for Food Applications

Cited by 2 publications

References 83 publications

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Hybrid films loaded with 5-fluorouracil and Reglan for synergistic treatment of colon cancer via asynchronous dual-drug delivery

Alginate-Based Electrospun Nanofibers and the Enabled Drug Controlled Release Profiles: A Review

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