Electrospun nanoyarn seeded with myoblasts induced from placental stem cells for the application of stress urinary incontinence sling: An in vitro study

Zhang, Kaile; Guo, Xuran; Li, Yan; Fu, Qiang; Mo, Xiumei; Nelson, Kyle C.; Zhao, Weixin

doi:10.1016/j.colsurfb.2016.03.083

Cited by 18 publications

(16 citation statements)

References 28 publications

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“…The fabrication of nanoyarn was reported previously using a co-axial electrospinning device (Donghua University, Shanghai) (Zhang et al, 2016; Figure 1B). Briefly, a hole (8 mm in diameter) was created in a basin, which allows the flow of water to form a water vortex.…”

Section: Core-shell Icg-001-delivering Nanoyarn Fabricationmentioning

confidence: 93%

Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model

Zhang

Fang

Zhu

et al. 2020

Front. Bioeng. Biotechnol.

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Hypospadias and urethral stricture are common urological diseases which seriously affect voiding function and life quality of the patients, yet current clinical treatments often result in unsatisfactory clinical outcome with frequent complications. In vitro experiments confirmed that ICG-001 (a well-established Wnt signaling inhibitor) could effectively suppress fibroblast proliferation and fibrotic protein expression. In this study, we applied a novel drug-delivering nanoyarn scaffold in urethroplasty in dog model, which continuously delivers ICG-001 during tissue reconstruction, and could effectively promote urethral recovery and resume fully functional urethra within 12 weeks. Such attempts are essential to the development of regenerative medicine for urological disorders and for broader clinical applications in human patients.

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Section: Core-shell Icg-001-delivering Nanoyarn Fabricationmentioning

confidence: 93%

Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model

Zhang

Fang

Zhu

et al. 2020

Front. Bioeng. Biotechnol.

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“…The method for fabricating nanoyarn was previously reported . Briefly, a dynamic liquid supporting system and electrospinning equipment were used to fabricate the nanoyarn scaffolds.…”

Section: Methodsmentioning

confidence: 99%

“…The materials were previously reported. 7 Briefly, P (LLA-CL) (LA: CL = 50:50, Mw = 300 000) was provided by Nara medical university (Shijocho, Japan). Type I collagen was obtained from Sichuan Ming-Rang Bio-Tech Co. Ltda.…”

Section: Methodsmentioning

confidence: 99%

“…The method for fabricating nanoyarn was previously reported. 7 Briefly, a dynamic liquid supporting system and electrospinning equipment were used to fabricate the nanoyarn scaffolds. A hole (8 mm in diameter) was created in a basin (40 cm in diameter, 20 cm in depth), so it allows the flow of water to form a water vortex.…”

Section: Nanoyarn Fabrication With a Dynamic Liquid Systemmentioning

confidence: 99%

“…The nanoyarn scaffolds were seeded with adipose‐derived stem cells (ADSCs), which possess highly efficient stemness and a minimally invasive procedure to harvest. In our previous study, the morphology and characteristics of nanoyarn and normal non‐woven nanofibrous scaffolds were tested and compared in vitro . In this study, we extended the research to in vivo models, by evaluating the efficacy, safety, and tissue development of nanoyarn as a suburethral sling in a rat model.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The fabrication of 3D surface scaffold of collagen/poly (L‐lactide‐co‐caprolactone) with dynamic liquid system and its application in urinary incontinence treatment as a tissue engineered sub‐urethral sling: In vitro and in vivo study

Zhang

Cao

Guo

et al. 2017

Neurourology and Urodynamics

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Advancements in scaffold for treating ligament injuries; in vitro evaluation

Liu,

Al‐Danakh,

Wang

et al. 2023

Biotechnology Journal

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Tendon/ligament (T/L) injuries are a worldwide health problem that affects millions of people annually. Due to the characteristics of tendons, the natural rehabilitation of their injuries is a very complex and lengthy process.Surgical treatment of a T/L injury frequently necessitates using autologous or allogeneic grafts or synthetic materials.Nonetheless, these alternatives have limitations in terms of mechanical properties and histocompatibility, and they do not permit the restoration of the original biological function of the tissue, which can negatively impact the patient's quality of life. It is crucial to find biological materials that possess the necessary properties for the successful surgical treatment of tissues and organs. In recent years, the in vitro regeneration of tissues and organs from stem cells has emerged as a promising approach for preparing autologous tissue and organs, and cell culture scaffolds play a critical role in this process. However, the biological traits and serviceability of different materials used for cell culture scaffolds vary significantly, which can impact the properties of the cultured tissues. Therefore, this review aims to analyze the differences in the biological properties and suitability of various materials based on scaffold characteristics such as cell compatibility, degradability, textile technologies, fiber arrangement, pore size, and porosity. This comprehensive analysis provides valuable insights to aid in the selection of appropriate scaffolds for in vitro tissue and organ culture.This article is protected by copyright. All rights reserved

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Electrospun nanoyarn seeded with myoblasts induced from placental stem cells for the application of stress urinary incontinence sling: An in vitro study

Cited by 18 publications

References 28 publications

Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model

Effective Reconstruction of Functional Urethra Promoted With ICG-001 Delivery Using Core-Shell Collagen/Poly(Llactide-co-caprolactone) [P(LLA-CL)] Nanoyarn-Based Scaffold: A Study in Dog Model

The fabrication of 3D surface scaffold of collagen/poly (L‐lactide‐co‐caprolactone) with dynamic liquid system and its application in urinary incontinence treatment as a tissue engineered sub‐urethral sling: In vitro and in vivo study

Advancements in scaffold for treating ligament injuries; in vitro evaluation

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