Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: Evaluations in vitro and in vivo

Wang, Liyang; Cheng, Wei; Zhu, Jingjing; Li, Wenyao; Li, Danyang; Yang, Xi; Zhao, Weixin; Ren, Ming; Ren, Jieji; Mo, Xiumei; Fu, Qiang; Zhang, Kaile

doi:10.1016/j.colsurfb.2021.112218

Cited by 26 publications

(22 citation statements)

References 47 publications

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“…For example, Wang et al proved that ASCs are capable of multi-potential—including lipogenic, osteogenic, and chondrogenic—differentiation, and developed ASC-Exos-delivering collagen/poly (L-lactide-co-caprolactone) (P (LLA-Cl)) nanoyarns, which conform to a material system that mimics the morphological structure of the natural tissue matrix. With sufficient biocompatibility and mechanical properties, it can effectively promote neovascularization, cell proliferation and tissue regeneration, and simultaneously limit scar formation, collagen deposition, and formation of multi-layer epithelium ( Wang et al, 2022 ). Liu et al showed that hyaluronic acid (HA) can be used as immobilizing agent in a constructed system of ASC-Exos with HA, to retain exosomes in the wound area and effectively play a role in wound repair.…”

Section: Discussion Of Adipogenic Stem Cells and Hypertrophic Scarringmentioning

confidence: 99%

“…In addition, advances in stem cell and tissue engineering have brought more alternative therapies closer to reality. Functionalization of biomaterials through various drugs and growth factors, provides a well-controlled approach to scar therapy ( Fuller et al, 2016 ; Rahimnejad et al, 2017 ; Wang et al, 2022 ).…”

Section: Current Mainstream Strategies For Inhibiting Scar Formationmentioning

confidence: 99%

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Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid

Chen

Hou

et al. 2022

Front. Cell Dev. Biol.

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Hypertrophic scars or keloid form as part of the wound healing reaction process, and its formation mechanism is complex and diverse, involving multi-stage synergistic action of multiple cells and factors. Adipose stem cells (ASCs) have become an emerging approach for the treatment of many diseases, including hypertrophic scarring or keloid, owing to their various advantages and potential. Herein, we analyzed the molecular mechanism of hypertrophic scar or keloid formation and explored the role and prospects of stem cell therapy, in the treatment of this condition.

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Section: Discussion Of Adipogenic Stem Cells and Hypertrophic Scarringmentioning

confidence: 99%

Section: Current Mainstream Strategies For Inhibiting Scar Formationmentioning

confidence: 99%

Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid

Chen

Hou

et al. 2022

Front. Cell Dev. Biol.

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“…26 Researchers have attempted to prepare different types of periodontal barrier membranes via electrospinning, casting membrane utilization, and dynamic filtration. Among them, electrospinning is an efficient method to prepare nanofibrous membranes, and it has found widespread application in biomedicine, especially for wound dressing, [27][28][29][30][31] tissue engineering, [32][33][34][35][36] and cancer treatment. 37 Electrospun nanofibrous membranes can mimic the scale and morphology of extracellular matrix (ECM) proteins, thus facilitating cell attachment, proliferation, and differentiation.…”

Section: Dovepressmentioning

confidence: 99%

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Zhao¹,

Chen²,

Feng³

et al. 2022

IJN

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Periodontitis is a major threat to oral health, prompting scientists to continuously study new treatment techniques. The nanofibrous membrane prepared via electrospinning has a large specific surface area and high porosity. On the one hand, electrospun nanofibers can improve the absorption capacity of proteins and promote the expression of specific genes. On the other hand, they can improve cell adhesion properties and prevent fibroblasts from passing through the barrier membrane. Therefore, electrospinning has unique advantages in periodontal treatment. At present, many oral nanofibrous membranes with antibacterial, anti-inflammatory, and tissue regeneration properties have been prepared for periodontal treatment. First, this paper introduces the electrospinning process. Then, the commonly used polymers of electrospun nanofibrous membranes for treating periodontitis are summarized. Finally, different types of nanofibrous membranes prepared via electrospinning for periodontal treatment are presented, and the future evolution of electrospinning to treat periodontitis is described.

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“…Electrospun nanofiber membranes have high porosity and large specific surface area, which can absorb the wound exudate in time, promote the transfer of nutrients in the wound environment, maintain the gas exchange at the wound site, and prevent the wound from dehydration [ 45 , 46 ]. In addition, the nanofiber membrane is soft, can be tailored to the size and shape of the wound, and is highly pliable; the nanofiber membrane protects the wound on a physical level and is able to protect the wound from other injuries and invasion by foreign microorganisms [ 47 , 48 , 49 , 50 , 51 ]. Electrospun nanofiber membranes can also be used as drug carriers to load anesthetics, antibacterial agents, bioactive molecules, etc., depending on different types of skin wounds (e.g., burns, trauma, chronic disease ulcers, etc.)…”

Section: Electrospinning Technologymentioning

confidence: 99%

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

Song

et al. 2022

Biomolecules

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The timely and effective control and repair of wound bleeding is a key research issue all over the world. From traditional compression hemostasis to a variety of new hemostatic methods, people have a more comprehensive understanding of the hemostatic mechanism and the structure and function of different types of wound dressings. Electrospun nanofibers stand out with nano size, high specific surface area, higher porosity, and a variety of complex structures. They are high-quality materials that can effectively promote wound hemostasis and wound healing because they can imitate the structural characteristics of the skin extracellular matrix (ECM) and support cell adhesion and angiogenesis. At the same time, combined with amino acid polymers with good biocompatibility not only has high compatibility with the human body but can also be combined with a variety of drugs to further improve the effect of wound hemostatic dressing. This paper summarizes the application of different amino acid electrospun wound dressings, analyzes the characteristics of different materials in preparation and application, and looks forward to the development of directions of poly(amino acid) electrospun dressings in hemostasis.

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Electrospun nanoyarn and exosomes of adipose-derived stem cells for urethral regeneration: Evaluations in vitro and in vivo

Cited by 26 publications

References 47 publications

Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid

Use of Adipose Stem Cells Against Hypertrophic Scarring or Keloid

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

A Review on Electrospun Poly(amino acid) Nanofibers and Their Applications of Hemostasis and Wound Healing

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