Electrospun nanofibrous CMC/PEO as a part of an effective pain-relieving wound dressing

Maver, Tina; Kurečič, Manja; Smrke, Dragica; Stana‐Kleinschek, Karin; Maver, Uroš

doi:10.1007/s10971-015-3888-9

Cited by 44 publications

(32 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the aim to control and treat DFUs, wound dressings able to absorb exudate, to prevent infections and to promote wound healing, are needed [89]. Chitosan (Chi) and Carboxymethylcellulose (CMC) are most common biodegradable and biocompatible polymers which could be used for the development of different modern wound dressings, either alone or as a part of multilayered wound dressings [90]. Several studies reported that silver nanoparticles (AgNPs) contribute to the wound healing process due to their antioxidant, antimicrobial and anti-inflammatory activity and to their simple incorporation in cotton fabric and dressings [91].…”

Section: In Vivo Evidence For Novel Brain Targeted Peptide-conjugatedmentioning

confidence: 99%

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

Pignatello

Matricardi

2020

Pharmaceutics

View full text Add to dashboard Cite

Besides the feasibility for industrial scale-up, accelerating the translation from bench to bedside of new technological strategies for controlled delivery and targeting of drugs and other actives relevant for health management, such as medical devices and nutraceuticals, would benefit from an even earlier evaluation in pre-clinical models and clinical settings. At the same time, translational medicine also performs in the opposite direction, incorporating clinical needs and observations into scientific hypotheses and innovative technological proposals. With these aims, the sessions proposed for the 2019 CRS Italy Chapter Workshop will introduce the experience of Italian and worldwide researchers on how to foster the actual work in controlled release and drug delivery towards a reliable pre-clinical and clinical assessment.

show abstract

Section: In Vivo Evidence For Novel Brain Targeted Peptide-conjugatedmentioning

confidence: 99%

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

Pignatello

Matricardi

2020

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…37 Clearly, creating a balance between the surface tension of ejected jet and electrical force is crucial to create a regular and uniform electrospun nanobers; which can be overcome by using the combination of CMC and PEG, as proven in our previous studies. 28,29 Fig. 2 shows the morphology of non cross-linked and cross-linked electrospun nanobers with 0, 5 and 10 wt% BTCA at 160 C. Results from other BTCA concentrations and temperatures, and drug incorporated samples are given in the supporting information ( Fig.…”

Section: Morphology Diameter and Surface Area Of Electrospun Nanobersmentioning

confidence: 99%

“…1, 2, 3, 4 butanetetracarboxylic acid, BTCA), which is eco-friendly, water soluble, and non-toxic, is suitable candidate for cross-linking of CMC/PEG nanobers. While the CMC/PEG based hydrogels have been used for drug delivery and wound dressing/healing applications, 28,29 the systematic and detailed studies on electrospun nanobers from the same polymers for the release of DCF and growth of human skin cells such as broblast are very few. Especially, no studies can be found on the thermal crosslinking and stabilization of CMC/PEG nanobers with BTCA through a sustainable, greener and two-steps approach.…”

Section: Introductionmentioning

confidence: 99%

A green approach to obtain stable and hydrophilic cellulose-based electrospun nanofibrous substrates for sustained release of therapeutic molecules

et al. 2019

Self Cite

View full text Add to dashboard Cite

Stable and (bio)-compatible nanofibrous matrices showing effective incorporation and release of nonsteroidal anti-inflammatory drugs (NSAIDs) hold a huge potential in tissue regeneration and wound healing. Herein, a two-step, water-based and needleless electrospinning method is used to fabricate thermally cross-linked multifunctional nanofibrous substrates from a hydrophilic cellulose derivative, i.e. carboxymethyl cellulose (CMC), and polyethylene glycol (PEG) with an in situ incorporated NSAID, diclofenac (DCF). Electrospun bi-component blend nanofibers, strongly linked together by ester bonds, with different degrees of cross-linking density are achieved by varying the concentrations of butanetetracarboxylic acid (BTCA, a green polycarboxylic cross-linker) and the sodium hypophosphite (SHP) catalyst, and the temperature. The results demonstrated that not only the dimensional stability and swelling properties could be better controlled but also the morphology, fiber diameter, surface area, pore volume, pore size, and functionality of the cross-linked nanofibers. Release kinetics of DCF from the nanofibrous substrates are controlled and prolonged up to 48 h, and the overall released mass of DCF decreased linearly with increasing cross-linking degree of BTCA and SHP. Fitting of release data using various kinetic models revealed that the release of DCF follows a non-Fickian (diffusion and erosion controlled) to Fickian mechanism (only diffusion-controlled process). Cell viability testing based on crystal violet dyeing showed that the DCF-incorporating nanofibers have excellent biocompatibility and no toxic effect on human skin fibroblast cells. Overall, the reported DCF-incorporating nanofibrous substrate demonstrates high potential to be used as a smart drug delivery system in wound healing, especially due to its noninvasive characteristics. † Electronic supplementary information (ESI) available: The information regarding the surface tension of CMC/PEG solutions admixed with different concentrations of BTCA, SEM, wettability, ATR-IR and cell viability results of electrospun samples cross-linked with different concentrations of BTCA at different temperatures are given. See Fig. 4 (A) ATR-FTIR absorption spectra of neat PEG, Na-CMC and BTCA, and non-heated CMC/PEG nanofibers with added BTCA_10%. (B) Spectrum of electrospun nanofibers cross-linked with BTCA_10% at different temperatures, (C) the absorption peak intensity ratio (1720 cm À1 / 1594 cm À1 ) of electrospun samples cross-linked with different BTCA concentrations and temperatures, (D) spectrum of pure DCF and DCF incorporated electrospun nanofibers cross-linked with different BTCA concentrations at 160 C.21294 | RSC Adv., 2019,9,[21288][21289][21290][21291][21292][21293][21294][21295][21296][21297][21298][21299][21300][21301] This journal is

show abstract

“…Likewise, Ninan et al [65] attribute their water solubility to their composition from the β-(1 → 4) glucopyranose residues. Its use in biomedicine as a biocompatible material has been proven [86]. Besides, Chen and Fan [87] studied their efficiency in clinical studies with humans and animals, finding that postoperative damages such as abdominal adhesions are reduced.…”

Section: Carboxymethylcellulosementioning

confidence: 99%

Overview of Electrospinned Chitosan Nanofiber Composites for Wound Dressings

Vega-Cázarez¹,

Sánchez‐Machado²,

JaimeLópez-Cervantes³

2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

View full text Add to dashboard Cite

Chitosan has a medical application because of its natural origin and properties of biodegradability, biocompatibility, nontoxicity, and antimicrobial capacity. Electrospinning produces non-woven nanofibers to wound dressing with high specific surface area and small pores. These properties are favorable for absorption of exudates and prevent the penetration of bacteria, thus promoting wound healing. For this reason, chitosan blends are used to produce nanofiber dressings, and the characterization of the structural, mechanical, and biological properties is very promising for further studies. Nowadays, the researchers are seeking for biomaterials that provide modern dressings with many qualities, which are designed to promote wound healing. In this chapter, the electrospinning parameters that affect the nanofiber properties based on chitosan to prepare wound dressings are highlighted.

show abstract

Electrospun nanofibrous CMC/PEO as a part of an effective pain-relieving wound dressing

Cited by 44 publications

References 47 publications

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

Steering the Clinical Translation of Delivery Systems for Drugs and Health Products

A green approach to obtain stable and hydrophilic cellulose-based electrospun nanofibrous substrates for sustained release of therapeutic molecules

Overview of Electrospinned Chitosan Nanofiber Composites for Wound Dressings

Contact Info

Product

Resources

About