Electrospun nanofibers of poly (lactic acid)/poly (ε‐caprolactone) blend for the controlled release of levetiracetam

Abstract

This study deals with poly(lactic acid) (PLA), poly(ε‐caprolactone) (PCL), and their blend electrospun nanofibers (ESNF) as novel systems for the release of levetiracetam (LEV). Scanning electron microscopy demonstrated that the morphology of all samples is smooth and beads‐free. In addition, with increasing LEV content, the average diameters of PLA, PCL, and PCL/PLA ESNF enhanced by almost 69%, 41%, and 14%, respectively. FTIR spectroscopy was utilized to confirm the structure of polymer and drug, polymer‐drug interaction, and the observation of functional groups. The pore percentage was also diminished by adding LEV. The results of x‐ray diffraction revealed that the crystallinity decreased from 18.2%, 40.1%, and 21.5% for PLA, PCL, and PLA/PCL ESNF, respectively, to 15%, 31.2%, and 13.6% for the samples containing 18 wt% LEV. In addition, PLA ESNF containing 10 and 18 wt% LEV demonstrated a steady uptrend for drug release, while PCL and PLA/PCL ESNF containing 10 and 18 wt% LEV initially indicated an abrupt increase in drug release and then became steady. Moreover, drug release kinetics were evaluated using different models such as zero order, first order, Higuchi, and Korsmeyer‐Peppas models and the best model for predicting the drug release behavior was selected.

Boron carbide reinforced electrospun nanocomposite fiber mats for radiation shielding

“…[26][27][28][29][30][31][32] On the other hand, the electrospinning process mostly utilized to manufacture biocompatible polymers for tissue engineering and biomedical applications since it can swiftly produce biopolymer fibers without creating any changes in the polymeric structure. [33][34][35][36][37][38] This method's operating mechanism begins with the creation of a stable solution. The solution's viscosity should be controlled tightly; otherwise, the solution cannot produce a continuous flow in the Taylor cone.…”

Correlation between non‐isothermal crystallization kinetics and morphology in poly(ε‐caprolactone)/poly(styrene‐co‐acrylonitrile) blends considering the blend phase behavior: Effects of poly(ε‐caprolactone) molecular weight

“…The final properties of the blend are determined by the characteristics of the constituents, their miscibility and the morphology of the phases. 8,9 The degree of miscibility of PCL/SAN blends is controlled by the acrylonitrile comonomer content in SAN, since it is believed that the miscibility of SAN with other polymers is mainly attributed to the thermodynamically unfavorable repulsion between styrene and acrylonitrile segments in the SAN random copolymer. 10,11 These blends are usually miscible for all concentrations in the range of 8%-28% by weight of acrylonitrile, otherwise they show immiscible behavior.…”

Environmentally friendly polypropylene/poly (trimethylene terephthalate) blend fibers: Resiliency and dyeability

“…[17][18][19][20][21] The blending technique is a valuable, versatile, and cost-effective method to prepare new high-performance materials, without the need to synthesize an entirely new polymer. [22][23][24][25][26][27][28][29][30] It is worth mentioning that PP is immiscible with most thermoplastic polymers. To overcome this drawback, compatibilizers can be added to the system, thereby improving the dispersion state of incompatible components.…”

“…17–21 The blending technique is a valuable, versatile, and cost-effective method to prepare new high-performance materials, without the need to synthesize an entirely new polymer. 22–30…”