Electrospun Nanofibers Embedded with Copper Oxide Nanoparticles to Improve Antiviral Function

Abstract

Many studies on anti-bacterial/antiviral surfaces have been conducted to prevent epidemic spread worldwide. Several nanoparticles such as those composed of silver and copper are known to have antiviral properties. In this study, we developed copper oxide (CuO) nanoparticle-incorporated nanofibers to inactivate or remove viruses. The CuO nanoparticle-incorporated nanofiber was fabricated with a hydrophobic polymer—polyvinylpyrrolidone (PVP)—using electrospinning, and CuO nanoparticles were exposed from the PVP polymer surface by etching the nanofiber with oxygen plasma. The fabrication conditions of electrospinning and oxygen plasma etching were investigated by scanning electron microscopy (SEM), and field emission transmission electron microscopy (FETEM)/ energy dispersive spectrometry (EDS). H1N1 virus was utilized as the target sample and quantified by RT-qPCR. The antiviral efficacy of CuO nanoparticle-incorporated nanofibers was compared against bare CuO nanoparticles. Overall, 70% of the viruses were inactivated after CuO nanoparticle-incorporated nanofibers were incubated with 102 pfu/mL of H1N1 virus solution for 4 h. This indicates that the developed CuO nanoparticle-incorporated nanofibers have noticeable antiviral efficacy. As the developed CuO nanoparticle-incorporated nanofibers exerted promising antiviral effects against H1N1 virus, it is expected to benefit global health by preventing epidemic spread.

Electrospun Biodegradable Nanofibers Coated Homogenously by Cu Magnetron Sputtering Exhibit Fast Ion Release. Computational and Experimental Study

“…The preparation of copper/copper oxide nanofibrous materials became a prevalent topic thanks to a vast range of applications of such nanomaterials, including catalysis [1,2], disinfection [3], antiviral nanocomposites [4], antibacterial wound dressings [5,6], sensors [7], CO 2 electrocatalytic reduction [8] and others. The advantage of using Cu nanofibers instead of other forms of nano or micromaterials is their high surface-to-volume ratio, the possibility to prepare sheets or foils of Cu nanofibers without any limitations in terms of their size, the opportunity to run the continuous roll-to-roll process, and its scalability.…”

Genome sequencing and genomic analysis ofAmycolatopsis tucumanensisDSM 45259 applicable in gray, red, and nano‐biotechnology

“…The synthesis of CuO-NPs by A. tucumanensis AB0 introduces the genus into the field of nano-biotechnology. CuO-NPs may be used as anticancer molecules, to improve antiviral functions and bioremediation processes [49][50][51]. Further studies will be focused on the characterization and potential application of these nanoparticles.…”

Zinc Oxide Nanoparticle-Loaded Electrospun Polyvinylidene Fluoride Nanofibers as a Potential Face Protector against Respiratory Viral Infections

“…The antiviral efficacy of CuO nanoparticle-incorporated nanofibers and results revealed that 70% of viruses were inactivated after 4 h of contact. 28 …”

“…The antiviral efficacy of CuO nanoparticle-incorporated nanofibers and results revealed that 70% of viruses were inactivated after 4 h of contact. 28 Here, the antiviral activity was tested against human adenovirus type-5 (ADV-5), which, in its structure, mimics respiratory viruses as it just needs the traditional facilities of BSL2. Adenoviruses are double-stranded DNA viruses having a genome around ∼36 kb long.…”