Electrospun nanofiber sorbents for the pre-concentration of urinary 1-hydroxypyrene

Ifegwu, Okechukwu Clinton; Anyakora, Chimezie; Chigome, Samuel; Torto, Nelson

doi:10.1186/s40543-015-0055-4

Cited by 1 publication

(18 citation statements)

References 33 publications

(62 reference statements)

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“…In most cases, a higher voltage will lead to greater stretching of the viscoelastic solution due to the greater columbic forces in the jet as well as the stronger electric field. These have the effect of reducing the diameter of the fibers [38,39] and also encourage faster solvent evaporation to yield drier fibers [1,2,40]. However, researchers had correlated an increase in beads' density to increased voltage and suggested it may be the result of increased instability of the jet as the Taylor cone recedes into the syringe needle [30,40].…”

Section: Applied Voltagementioning

confidence: 99%

“…In addition to affecting fiber physical appearance, the application of high voltage during electrospinning will likely increase the order of polymer molecules, resulting in higher polymer fiber crystallinity [1,2,[10][11][12][13][14]. Nevertheless, polymer fiber crystallinity is reduced beyond a certain voltage [1, 2, 10-14].…”

Section: Applied Voltagementioning

confidence: 99%

“…The material, nature, and geometry of the collector play a major role in defining the morphology of the fibers [13]. Several different shapes of collectors such as flat plate; rotating drum, mandrel, rotating disc, rectangular, triangular, or wire cylinder frame; electrode pair arrangements; ring and mesh electrode; and cones have been reported [1,2,[10][11][12][13][14]26]. It has also been demonstrated that some of the common solvents such as water [46] and methanol [46] could be better collectors than their solid counterparts.…”

Section: Effect Of Collectormentioning

confidence: 99%

“…An important and exciting direction of research in nanomedicine would be to gain an in-depth understanding and exploit the cellular response to nanostructures. For example, electrospunnanofibers have diameter in the nanometer range, are arbitrarily long, and possess larger surface area (to volume ratio), interfibrous pore sizes, strong penetrability, great deal of active sites for adsorption, and better interaction with other compounds as compared to their microfibers counterpart [1,2]. They have excellent stability, better targeting, minimum toxicity, high drug-loading capacity, exceptional mechanical properties, flexibility in surface functionality, and encapsulation of drugs and bioactive compounds and are suitable for thermos-liable drugs [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…The generated fibers have a high surface area to volume ratio; the fibrous mats are highly porous and display excellent mechanical properties when compared to other materials of the same scale. Interestingly, the characteristic high surface area to volume ratio of electrospunnanofiber scaffolds does enhance cell attachment, drug loading, and mass transfer properties [1,2,[8][9][10]. Consequently, business opportunities for nanostructured materials in biomedical applications were estimated as on 2006 by Ramakrishna et al and Teo et al to be of the order of 180 billion US dollars in 2015 [11,12].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The Place of Electrospinning in Separation Science and Biomedical Engineering

Ifegwu¹,

Anyakora²

2018

Electrospinning Method Used to Create Functional Nanocomposites Films

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Electrospunnanofibers have found myriad of applications from separation science to clinical translation. Electrospunnanofiber scaffolds have the benefits of unique properties such as high surface area to volume ratio, interfibrous pore sizes, strong penetrability, great deal of active sites for adsorption, excellent stability, better targeting, minimum toxicity, high drug-loading capacity, exceptional mechanical properties, flexibility in surface functionality, ease of encapsulation of drugs and bioactive compounds, suitability for thermos-liable drugs, enhanced cellular interactions, and protein absorption to facilitate binding sites for cell receptors. In the field of separation science, electrospunnanofiber scaffolds have extensively served as sorbent material for solid phase extraction techniques mainly due to the need to improve sorptive capacity and analyte selectivity. Given that almost all of the human tissues and organs are deposited in nanofibrous forms or structures, electrospunnanofibers/ nanocomposites are currently being investigated for potential clinical applications. It is noteworthy that the nanofiber fabrication technique and the material integrity are key components to obtaining clinically relevant nanofibers. Owing to the significance of fiber arrangement to nanofiber performance, electrospinning has a leading edge over other nanofiber fabrication techniques due to the ease of controlling fiber orientation, despite the inherent advantages of other conventional nanofiber fabrication techniques. The current review highlights the superb qualities of electrospunnanofibers, their various methods of fabrication, and their various applications especially in separation science and clinically. We further provided an overview of the electrospinning principles, types of electrospinning, parameters that affect the nanofibers fabrication via electrospinning, challenges, and the future directions. The advent of robotics-assisted electrospinning technique offers new opportunities for the traditional biofabrication in higher accuracy and controllability and hence will certainly drive nanotechnology from laboratory/industry toward patient care in the near future.

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