Electrospun hydrogels composites for bone tissue engineering

Gelatin nanofibers: Recent insights in synthesis, bio-medical applications and limitations

“…Osteoconduction is the ability to permit the bone tissue to grow and rearrange on the implanted nanomaterials surface. These materials help in the osteoinduction and osteogenesis [ 110 ].…”

“…Interestingly, the osteoconductive scaffolds in the absence of bioactive molecules and stem cells loss the ability to form a new bone, however, osteoinduction signals growth factor and molecules help in bone formation. Electrospun scaffolds with morphogenic proteins (osteoinductive agent) can attract the mesenchymal stem cells [ 110 ]. Then the stem cells develop to preosteoblasts for ultimate bone formation.…”

“…cells taken from injured bone upon the nanofibers scaffold and growth factor stimulate the cell proliferation and differentiation. The scaffold implanted in the injured part of bone and lead finally formation of new tissues [ 110 ] as shown in Fig. 7 .…”

Antibacterial Hydrogels Derived from Poly(γ-glutamic acid) Nanofibers

“…These hydrogels based on nanofibers of specific diameter are interesting for advanced requirements in the field of biomedical applications. These mainly involve drug delivery systems and regenerative medicine as demonstrated by the increasing number of patents concerning the use of electrospun hydrogels, which can easily offer antimicrobial, anti-inflammatory and antioxidant activities [ 25 ]. Furthermore, great efforts are nowadays focused on the scale-up of electrospinning from the laboratory to an industrial production level, with the nanofiber worldwide market size was estimated to noticeably increase up to 1 billion USD by the end of 2020 [ 26 ].…”