Electrospun herbal nanofibrous wound dressings for skin tissue engineering

Mary, Soloman Agnes; Dev, V. R. Giri

doi:10.1080/00405000.2014.951247

Cited by 83 publications

(43 citation statements)

References 19 publications

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“…Their results indicated that the addition of essential oil decreased the contact angle value compare to pure PCL (Jin et al, 2013), which is in agreement with our results. In another study, findings of Agnes Mary and Giri Dev (2015) indicated that PCL electrospun matrices comprising aloe vera (AV) had lower contact angle values when the AV concentration increased.…”

Section: Discussionmentioning

confidence: 98%

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Physical and Antibacterial Properties of Peppermint Essential Oil Loaded Poly (ε-caprolactone) (PCL) Electrospun Fiber Mats for Wound Healing

Ünalan

Slavik

Buettner

et al. 2019

Front. Bioeng. Biotechnol.

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The aim of this study was to fabricate and characterize various concentrations of peppermint essential oil (PEP) loaded on poly(ε-caprolactone) (PCL) electrospun fiber mats for healing applications, where PEP was intended to impart antibacterial activity to the fibers. SEM images illustrated that the morphology of all electrospun fiber mats was smooth, uniform, and bead-free. The average fiber diameter was reduced by the addition of PEP from 1.6 ± 0.1 to 1.0 ± 0.2 µm. Functional groups of the fibers were determined by Raman spectroscopy. Gas chromatography-mass spectroscopy (GC-MS) analysis demonstrated the actual PEP content in the samples. In vitro degradation was determined by measuring weight loss and their morphology change, showing that the electrospun fibers slightly degraded by the addition of PEP. The wettability of PCL and PEP loaded electrospun fiber mats was measured by determining contact angle and it was shown that wettability increased with the incorporation of PEP. The antimicrobial activity results revealed that PEP loaded PCL electrospun fiber mats exhibited inhibition against Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative) bacteria. In addition, an in-vitro cell viability assay using normal human dermal fibroblast (NHDF) cells revealed improved cell viability on PCL, PCLPEP1.5, PCLPEP3, and PCLGEL6 electrospun fiber mats compared to the control (CNT) after 48 h cell culture. Our findings showed for the first time PEP loaded PCL electrospun fiber mats with antibiotic-free antibacterial activity as promising candidates for wound healing applications.

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Section: Discussionmentioning

confidence: 98%

“…In vitro degradation experiments were carried out as described previously (Agnes Mary and Giri Dev, 2015). Briefly, the electrospun fiber mats were cut into 3 ×3 cm 2 pieces, which had an initial weight of around 30 mg.…”

Section: In Vitro Degradationmentioning

confidence: 99%

Physical and Antibacterial Properties of Peppermint Essential Oil Loaded Poly (ε-caprolactone) (PCL) Electrospun Fiber Mats for Wound Healing

Ünalan

Slavik

Buettner

et al. 2019

Front. Bioeng. Biotechnol.

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“…The topography of such scaffolds has been shown to dictate cellular attachment, migration, proliferation, and differentiation, which are critical steps in tissue engineering [77,78,79]. Aloe vera based scaffolds can be fabricated using a variety of techniques [11,12,15]. Electrospinning, and freeze drying (or, thermal induced phase separation) are two techniques, which have been investigated for production of aloe vera based scaffolds.…”

Section: Aloe Vera Based Tissue Engineering Scaffoldsmentioning

confidence: 99%

“…Mary and Dev [12] studied the degradation and wettability behavior of aloe vera incorporated PCL electrospun matrices. The aloe vera incorporated PCL matrices degraded at a faster rate compared to PCL matrices, and the hydrophilicity of the fiber mats increased on blending the aloe vera with PCL polymer.…”

Section: Aloe Vera Based Tissue Engineering Scaffoldsmentioning

confidence: 99%

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Aloe Vera for Tissue Engineering Applications

Rahman

Carter

Bhattarai

2017

JFB

144

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Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

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