Electrospun diamond-silk membranes for biosensing applications

Khalid, Asma; Abraham, Amanda N.; Bai, Dongbi; Jadhav, Amit; Linklater, Denver P.; Nguyên, Duy Duong; Matusica, Alex; Dekiwadia, Chaitali; Vidanapathirana, Achini K.; Reineck, Philipp; Bursill, Christina A.; Иванова, Е. А.; Houshyar, Shadi; Greentree, Andrew D.

doi:10.1117/12.2539276

Cited by 4 publications

(9 citation statements)

References 4 publications

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“…The study confirmed the effective chimeric coupling of silver ions from a solution, resulting in potent inhibitory effects on both Gram-positive and Gram-negative bacteria [196]. Apart from silver, carbon in the shape of nanodiamonds incorporated into electrospun silk nanofibres showed antibacterial behaviour [197]. As another example, the antibacterial properties of selenium nanoparticles could further be enhanced by coating them with positively charged recombinant eADF4(κ16) silk proteins (Figure 4B) [184].…”

Section: Antimicrobial Silk-based Surfacessupporting

confidence: 57%

Bioselectivity of silk protein-based materials and their bio-inspired applications

Bargel¹,

Trossmann²,

Sommer³

et al. 2022

Beilstein J. Nanotechnol.

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Adhesion to material surfaces is crucial for almost all organisms regarding subsequent biological responses. Mammalian cell attachment to a surrounding biological matrix is essential for maintaining their survival and function concerning tissue formation. Conversely, the adhesion and presence of microbes interferes with important multicellular processes of tissue development. Therefore, tailoring bioselective, biologically active, and multifunctional materials for biomedical applications is a modern focus of biomaterial research. Engineering biomaterials that stimulate and interact with cell receptors to support binding and subsequent physiological responses of multicellular systems attracted much interest in the last years. Further to this, the increasing threat of multidrug resistance of pathogens against antibiotics to human health urgently requires new material concepts for preventing microbial infestation and biofilm formation. Thus, materials exhibiting microbial repellence or antimicrobial behaviour to reduce inflammation, while selectively enhancing regeneration in host tissues are of utmost interest. In this context, protein-based materials are interesting candidates due to their natural origin, biological activity, and structural properties. Silk materials, in particular those made of spider silk proteins and their recombinant counterparts, are characterized by extraordinary properties including excellent biocompatibility, slow biodegradation, low immunogenicity, and non-toxicity, making them ideally suited for tissue engineering and biomedical applications. Furthermore, recombinant production technologies allow for application-specific modification to develop adjustable, bioactive materials. The present review focusses on biological processes and surface interactions involved in the bioselective adhesion of mammalian cells and repellence of microbes on protein-based material surfaces. In addition, it highlights the importance of materials made of recombinant spider silk proteins, focussing on the progress regarding bioselectivity.

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Section: Antimicrobial Silk-based Surfacessupporting

confidence: 57%

Bioselectivity of silk protein-based materials and their bio-inspired applications

Bargel¹,

Trossmann²,

Sommer³

et al. 2022

Beilstein J. Nanotechnol.

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“…Electrospinning NDs with various polymers has been reported in the literature (Houshyar et al, 2019;Khalid et al, 2019;Mahdavi et al, 2016). Khalid healing along with the capability for temperature sensing (Khalid et al, 2019). Similar studies have been done on electrospun polycaprolactone with NDs for enhancing mechanical strength and adding photoluminescence of the nanofibre products for bone tissue engineering (Brady et al, 2015;Parizek et al, 2012).…”

Section: Electrospinning and Melt Processing Of Nanodiamond Compositesmentioning

confidence: 88%

“…Electrospinning is a simple, rapid and efficient method to make nano/micro fibres from polymer solution by applying electrostatic forces, as seen in Figure 8. Electrospinning NDs with various polymers has been reported in the literature (Houshyar et al, 2019;Khalid et al, 2019;Mahdavi et al, 2016). Khalid healing along with the capability for temperature sensing (Khalid et al, 2019).…”

Section: Electrospinning and Melt Processing Of Nanodiamond Compositesmentioning

confidence: 99%

“…Khalid et al reported silk electrospun membranes with NDs for biosensing applications in wound dressings. Results showed enhancement of cell growth and healing along with the capability for temperature sensing (Khalid et al, 2019). Similar studies have been done on electrospun polycaprolactone with NDs for enhancing mechanical strength and adding photoluminescence of the nanofibre products for bone tissue engineering (Brady et al, 2015; Parizek et al, 2012).…”

Section: Fabrication and Application Of Different Diamond Surfaces Fomentioning

confidence: 99%

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Diamond in medical devices and sensors: An overview of diamond surfaces

et al. 2020

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The human body is a sophisticated environment for research. There has been progress in developing advanced medical devices and sensors to contribute to recovery and therapy. However, as the field progresses new materials with specific properties are required to maximize recovery and therapy efficiency. Desired properties include materials that can contribute to cell regeneration and proliferation while preventing bacterial biofilm formation. Additionally, the variability in geometries of diseased parts requires improvement in processing to provide case and geometry-specific solutions (Raghavendra et al., 2015). Hence, there is a need for novel biomaterials that better match the native tissue. Their effectiveness and functionality are crucial to the long-term physical activity and health of patients. Carbon-based materials have attracted attention due to their unique characteristics, including mechanical, thermal and optical properties (Martel-Estrada, 2018), and they have been used in the

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“…Diamond coatings allowed reduced levels of acute, chronic inflammatory, and foreign-body reactions, showing that diamonds are well tolerated in vivo [15]. Diamond is a promising inorganic material for the fabrication of biomedical implants and sensors, bioimaging, gene therapy and drug delivery applications [16,17]. Diamond-polymer coatings combined advanced properties of diamonds and polymers [3].…”

Section: Introductionmentioning

confidence: 99%

Surfactant assisted dip-coating method for deposition of polyethylmethacrylate-diamond coatings

Wang

Zhitomirsky

2023

Advances in Applied Ceramics: Structural, Functional and Biocer

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This investigation is motivated by increasing interest in polymer-diamond coatings for biomedical applications in implants and sensors. A conceptually new strategy is based on the feasibility of solubilisation of polyethyl methacrylate (PEMA) in isopropanol using 18βglycyrrhetinic acid (GRA) and rhamnolipids (RLP) as solubilising agents. This approach offers benefits for biomedical applications by avoiding the use of traditional toxic solvents for PEMA dissolution. The ability to obtain concentrated solutions of high molecular mass polymer is a crucial factor for the development of a dip coating method. Potentiodynamic and impedance spectroscopy studies indicate that PEMA films provide corrosion protection of stainless steel in 3% NaCl solutions. The use of GRA facilitates the fabrication of films with improved protective properties. PEMA films are obtained as monolayers or multilayers of controlled film mass. Another important finding is a good dispersion of chemically inert microdiamond and nanodiamond particles using GRA and RLP. For the first time composite PEMA-diamond films are obtained using GRA and RLP as solubilising agents for PEMA and dispersing agents for diamonds in isopropanol solvent. The detailed analysis of film microstructures provides an insight into the influence of chemical structure of GRA and RLP on their interactions with PEMA and diamonds. Moreover, microstructure analysis indicates that such interactions are important for preventing defects in the composite films. The benefits of steroid-like dispersants are discussed. Composite films are obtained as monolayers with different diamond content or PEMA-diamond multilayers of different composition and film mass. The method represents a versatile strategy for the fabrication of alternating PEMA/PEMA-diamond multilayers. The benefits of the obtained microstructures for biomedical applications are discussed. The approach developed in this investigation opens an avenue for the fabrication of other polymer coatings containing various functional materials.

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Electrospun diamond-silk membranes for biosensing applications

Cited by 4 publications

References 4 publications

Bioselectivity of silk protein-based materials and their bio-inspired applications

Bioselectivity of silk protein-based materials and their bio-inspired applications

Diamond in medical devices and sensors: An overview of diamond surfaces

Surfactant assisted dip-coating method for deposition of polyethylmethacrylate-diamond coatings

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