Electrospun core/shell nanofibers as designed devices for efficient Artemisinin delivery

Bonadies, Irene; Maglione, Luca; Ambrogi, Veronica; Paccez, Juliano D.; Zerbini, Luiz F.; Silva, Luiz F. Rocha e; Picanço, Neila Soares; Tadei, Wanderli Pedro; Grafova, Iryna; Grafov, Andriy; Carfagna, Cosimo

doi:10.1016/j.eurpolymj.2017.02.015

Cited by 37 publications

(19 citation statements)

References 50 publications

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“…Applications of porous electrospun fibres can range from sorbent materials for oil spill clean-up [4] to moisture wicking materials for sportwear [5]. Biomedical applications of these materials include scaffolds for tissue engineering [6][7] and carriers for drug delivery [8]. In tissue engineering, the porous fibres can mimic the native extracellular matrix (ECM) and the surface pores facilitate cell attachment, which is important for the restoration and regeneration of damaged tissue and organs [9].…”

Section: Introductionmentioning

confidence: 99%

Fabricating porous poly(lactic acid) fibres via electrospinning

Huang

Thomas

2018

European Polymer Journal

149

115

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In this paper, amorphous poly(lactic acid) (PLA), a biodegradable polymer with excellent biocompatibility, is successfully electrospun into micron-sized fibres with controlled surface and internal morphologies. By careful solvent selection, either surface porosity or internal porosity can be achieved through different mechanisms. Use of chloroform as the solvent gives rise to circular pores of 100 nm diameter confined to the surface. These are obtained in humid conditions by the so-called 'Breath Figure' mechanism. It is found that combining chloroform with a water-miscible non-solvent yields either surface porosity (wrinkled effect) using a low boiling point liquid, e.g. ethanol, or internal porosity using a high boiling point liquid, e.g. dimethyl sulphoxide (DMSO). Both these microstructures are obtained through a non-solvent induced phase separation (NIPS) mechanism. Finally, it is found possible to produce both surface and internal porosity using DMSO by a vapour induced phase separation (VIPS) mechanism. The porous electrospun PLA mats were shown to exhibit significantly increased oil absorption capacity compared with the non-porous fibre mats.

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Section: Introductionmentioning

confidence: 99%

Fabricating porous poly(lactic acid) fibres via electrospinning

Huang

Thomas

2018

European Polymer Journal

149

115

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“…A nanofiber made of poly(vinyl pirrolidone) as a shell and hyperbranched poly(ethylene adipate) as a core that contained the Artenisimin (ART) drug was produced. An [3-(4,5 dimethyl-2 thiazolyl) (2,5 diphenyl-2H-tetrazolium bromide)] MTT assay showed that this polymer nanocomposite contributed to reducing prostatic cancer cell viability [30].…”

Section: Introductionmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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“…Poly(vinyl pyrrolidone) (type K90) was obtained from Tianjin Bodi Chemical Co., Ltd., and was chosen as the raw material for this study because it is widely used for solution electrospinning . An 8 wt % electrospinning solution was prepared in EtOH and magnetically stirred for 3 h at room temperature before the experiment.…”

Section: Methodsmentioning

confidence: 99%

Solution electrospinning with a pulsed electric field

Wang

Xie

et al. 2017

J of Applied Polymer Sci

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Getting finer fibers is one important goal of electrospinning. In this article, we introduce orthogonal experimental research of solution electrospinning with a pulsed electric field. The influences of the voltage, flow rate, frequency, and duty cycle on the mean diameter and diameter distribution of electrospun fibers were investigated. The phenomenon of electrospinning in a pulsed electric field was compared to that of electrospinning in an ordinary electric field. We found that the order of the factors that affected the fiber diameter was Duty cycle > Flow rate > Voltage > Frequency and the order of factors that affected the fiber diameter distribution was Duty cycle > Flow rate > Frequency > Voltage. In addition, compared with the ordinary electric field, the pulsed electric field apparently contributed to reductions in the mean fiber diameter and diameter distribution. In this article, we provide important evidence for the reduction of the fiber diameter with the pulsed electric field. V C 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46130.

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Electrospun core/shell nanofibers as designed devices for efficient Artemisinin delivery

Cited by 37 publications

References 50 publications

Fabricating porous poly(lactic acid) fibres via electrospinning

Fabricating porous poly(lactic acid) fibres via electrospinning

Polymers and Polymer Nanocomposites for Cancer Therapy

Solution electrospinning with a pulsed electric field

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