Electrospun conductive nanofibrous scaffolds for engineering cardiac tissue and 3D bioactuators

Wang, Ling; Wu, Yaobin; Hu, Tianli; Guo, Baolin; Peter, X.

doi:10.1016/j.actbio.2017.06.036

Cited by 267 publications

(208 citation statements)

References 66 publications

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“…Hydrophilicity of the scaffold is the key issue for cell adhesion and proliferation because hydrophilicity can affect the adhesion of serum proteins . Figure presents the hydrophilicity of different scaffolds including surface contact angle analysis and wicking effect measurement.…”

Section: Resultsmentioning

confidence: 99%

Controllable Aligned Nanofiber Hybrid Yarns with Enhanced Bioproperties for Tissue Engineering

Liu

Mao

et al. 2019

Macro Materials & Eng

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Electrospun nanofibers have large surface area, high porosity, and controllable orientation while conventional microfibers have appropriate mechanical properties such as stiffness, strength, and elasticity. Therefore, the combination of nanofibers and microfibers can provide building elements to engineer biomimetic scaffolds for tissue engineering. In this study, a core–shell structured fibrous structure with controllable surface topography is created by electrospinning polycaprolactone (PCL) nanofibers onto polyglycolic acid (PGA) microfibers. The surface morphology, surface wettability, and mechanical properties of the resultant core–shell structure are characterized. FE‐SEM images reveal that the orientation of PCL nanofibers on the yarn surface can be tuned by a fiber collector and rotating disks. Benefiting from the introduction of a shell of aligned PCL nanofibers on the core of PGA yarn, the uniaxially aligned PCL nanofiber–covered yarns (A‐PCLs) exhibit higher hydrophilicity, porosity, and mechanical properties than the core PGA yarns. Moreover, A‐PCLs promote the adhesion and proliferation of BALB/3T3 (mouse embryonic fibroblast cell line), and guide cell growth along the biotopographic cues of the PCL nanofibers with controllable alignment. The developed core–shell yarn having both the desired surface topography of PCL nanofibers and mechanical properties of PGA microfibers demonstrates great potential in constructing various tissue scaffolds.

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Section: Resultsmentioning

confidence: 99%

Controllable Aligned Nanofiber Hybrid Yarns with Enhanced Bioproperties for Tissue Engineering

Liu

Mao

et al. 2019

Macro Materials & Eng

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“…Furthermore, PLA/PANi nanofibrous sheets enhanced the cell–cell junction, spreading and alignment of primary cardiomyocytes along with higher expression of sarcomeres and gap junction proteins. Moreover, the cardiomyocytes‐laden PLA/PANi conductive nanofibrous sheets could exhibit 3D bioactuators with tubular and folding shapes, and spontaneous contraction with much higher frequencies and displacement than that of cardiomyocytes‐laden PLA nanofibrous sheets (Wang et al, ).…”

Section: Electroconductive Scaffoldsmentioning

confidence: 99%

Electrically conductive materials for in vitro cardiac microtissue engineering

Baei

Hosseini

Baharvand

et al. 2020

J Biomedical Materials Res

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Cardiac tissue engineering, a fairly new concept in cardiovascular research, could substantially improve our success in both in vitro modeling of cardiac microtissue and in vivo cardiac regenerative medicine. To a large extent, this success was attributed to mechanical as well as electrical properties of cardiac‐designated biomaterials which inherit the fundamental characteristics of a native myocardial extracellular matrix. Large efforts have been made toward designation and construction of these scaffolds which paved the way for more natural‐like biomaterials. As an important characteristic, electrical conductivity has grabbed special attention, thus opening up a whole new area of research to achieve the best biomaterial. Electroconductive scaffolds have benefitted from both incorporation of conductive particles in polymeric matrix and fabrication of organic conductive polymers which supported cardiac tissue engineering. However, conductive scaffolds have not yet achieved full success and more work is required to obtain the optimal conductivity with highest similarity to the native heart for in vitro cardiac microtissue engineering.

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“…Owing to shortage of heart donors, it is necessary to develop new approaches for regeneration of the injured myocardium. Cardiac tissue engineering is a multidisciplinary approach to restore damaged heart tissue by appropriate cells and scaffolds (Wang, Wu, Hu, Guo, & Ma, ). Scaffolds should support cell adhesion, migration, proliferation, and function.…”

Section: Introductionmentioning

confidence: 99%

“…Cardiac tissue engineering is a multidisciplinary approach to restore damaged heart tissue by appropriate cells and scaffolds (Wang, Wu, Hu, Guo, & Ma, 2017). Scaffolds should support cell adhesion, migration, proliferation, and function.…”

mentioning

confidence: 99%

Development of electrically conductive hybrid nanofibers based on CNT‐polyurethane nanocomposite for cardiac tissue engineering

Shokraei

Asadpour

Shokraei

et al. 2019

Microscopy Res & Technique

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Conductive nanofibers have been considered as one of the most interesting and promising candidate scaffolds for cardiac patch applications with capability to improve cell–cell communication. Here, we successfully fabricated electroconductive nanofibrous patches by simultaneous electrospray of multiwalled carbon nanotubes (MWCNTs) on polyurethane nanofibers. A series of CNT/PU nanocomposites with different weight ratios (2:10, 3:10, and 6:10wt%) were obtained. Scanning electron microscopy, conductivity analysis, water contact angle measurements, and tensile tests were used to characterize the scaffolds. FESEM showed that CNTs were adhered on PU nanofibers and created an interconnected web‐like structures. The SEM images also revealed that the diameters of nanofibers were decreased by increasing CNTs. The electrical conductivity, tensile strength, Young's modulus, and hydrophilicity of CNT/PU nanocomposites also enhanced after adding CNTs. The scaffolds revealed suitable cytocompatibility for H9c2 cells and human umbilical vein endothelial cells (HUVECs). This study indicated that simultaneous electrospinning and electrospray can be used to fabricate conductive CNT/PUnanofibers, resulting in better cytocompatibility and improved interactions between the scaffold and cardiomyoblasts.

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Electrospun conductive nanofibrous scaffolds for engineering cardiac tissue and 3D bioactuators

Cited by 267 publications

References 66 publications

Controllable Aligned Nanofiber Hybrid Yarns with Enhanced Bioproperties for Tissue Engineering

Controllable Aligned Nanofiber Hybrid Yarns with Enhanced Bioproperties for Tissue Engineering

Electrically conductive materials for in vitro cardiac microtissue engineering

Development of electrically conductive hybrid nanofibers based on CNT‐polyurethane nanocomposite for cardiac tissue engineering

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